アダプタータンパク質、アダプター蛋白質、アダプタータンパク、アダプター蛋白
WordNet
- make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- (…に)…'を'『適応させる』,適合させる《+『名』+『to』+『名』(do『ing』)》 / (…向きに)〈小説・戯曲など〉'を'『脚色する』,翻案する,書きかえる《+『名』+『for』+『名』》 / (環境などに)適応する,順応する《+『to』+『名』》
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/18 17:24:46」(JST)
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Src-associated adaptor protein Skap2 with 1u5e code
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves[1] but instead mediate specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MyD88, Grb2 and SHC1.
Contents
- 1 Signaling components
- 2 Domains
- 3 Genes
- 4 See also
- 5 References
- 6 Further reading
Signaling components
Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short lived active complexes in response to an activating signal such as a growth factor binding to its receptor.
Domains
Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow specific interactions with several other specific proteins. SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins.
There are many other types of interaction domains found within adaptor and other signalling proteins that allow a rich diversity of specific and coordinated protein–protein interactions to occur within the cell during signal transduction.
Genes
Genes encoding adaptor proteins include:
- BCAR3 – Breast cancer anti-estrogen resistance protein 3
- GRAP – GRB2-related adaptor protein
- GRAP2 – GRB2-related adaptor protein 2
- LDLRAP1 – low-density lipoprotein receptor adaptor protein 1
- NCK1 – NCK adaptor protein 1
- NCK2 – NCK adaptor protein 2
- NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
- PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
- SH2B1 – SH2B adaptor protein 1
- SH2B2 – SH2B adaptor protein 2
- SH2B3 – SH2B adaptor protein 3
- SH2D3A -SH2 domain containing 3A
- SH2D3C – SH2 domain containing 3C
- SHB – Src homology 2 domain containing adaptor protein B
- SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
- GAB2 – GRB2-associated binding protein 2
See also
- Wikipedia:MeSH D12.776#MeSH D12.776.157.057 --- adaptor proteins.2C signal transducing
- Wikipedia:MeSH D12.776#MeSH D12.776.543.990.150 --- adaptor proteins.2C vesicular transport
References
- ^ Signal Transducing Adaptor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Further reading
- TAB2 is an adaptor protein involved in the IL-1 signal transduction pathway: Takaesu, Giichi; Kishida, Satoshi; Hiyama, Atsushi; Yamaguchi, Kyoko; Shibuya, Hiroshi; Irie, Kenji; Ninomiya-Tsuji, Jun; Matsumoto, Kunihiro (2000). "TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway". Molecular Cell 5 (4): 649–658. doi:10.1016/S1097-2765(00)80244-0. ISSN 1097-2765. PMID 10882101.
- Good article about adaptor proteins involved in protein kinase C-mediated signal transduction: Schechtman D, Mochly-Rosen D (October 2001). "Adaptor proteins in protein kinase C-mediated signal transduction". Oncogene 20 (44): 6339–47. doi:10.1038/sj.onc.1204778. PMID 11607837. Retrieved 2012-09-05.
- A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor: Samelson, Lawrence E. (2002). "SIGNALTRANSDUCTIONMEDIATED BY THET CELLANTIGENRECEPTOR: The Role of Adapter Proteins*". Annual Review of Immunology 20 (1): 371–394. doi:10.1146/annurev.immunol.20.092601.111357. ISSN 0732-0582.
- Signalling discussed with regards to adaptor proteins: Pawson, T. (1997). "Signaling Through Scaffold, Anchoring, and Adaptor Proteins". Science 278 (5346): 2075–2080. doi:10.1126/science.278.5346.2075. ISSN 0036-8075.
Cell physiology: Cell signaling / Signal transduction
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Signaling pathways |
- GPCR
- RTK
- Notch
- JAK-STAT
- Akt/PKB
- Fas apoptosis
- Hippo
- PI3K/AKT/mTOR pathway
- Integrin receptors
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Agents |
Receptor ligands |
- Hormones
- Neurotransmitters/Neuropeptides/Neurohormones
- Cytokines
- Growth factors
- Signaling molecules
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Receptors |
- Cell surface
- Intracellular
- Co-receptor
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2nd messenger |
- cAMP-dependent pathway
- Ca2+ signaling
- Lipid signaling
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Assistants: |
- Signal transducing adaptor protein
- Scaffold protein
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Transcription factors |
- General
- Transcription preinitiation complex
- TFIID
- TFIIH
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By distance |
- Juxtacrine
- Autocrine / Paracrine
- Endocrine
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Other concepts |
- Intracrine action
- Neurocrine signaling
- Synaptic transmission
- Chemical synapse
- Neuroendocrine signaling
- Exocrine signalling
- Mechanotransduction
- Phototransduction
- Ion channel gating
- Gap junction
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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Proteins: carrier proteins
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Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
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Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
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Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
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Vitamin |
- Retinol binding protein
- Transcobalamin
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Pigment |
- Plant Light-Harvesting Complex
- Orange Carotenoid Protein
- Phycobiliprotein
- Photosynthetic Reaction Centers
- Phytochrome
- Rhodopsin
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Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
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Index of proteins
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Description |
- Proteins
- Membrane
- Globular
- Antibodies
- Fibrous
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Cell signaling: carrier proteins: signal transducing adaptor proteins
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JAK-STAT |
- see JAK-STAT signaling pathway
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Growth factor receptor-bound protein |
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Other |
- 14-3-3
- Caveolin
- Cortactin
- Death-inducing signaling complex
- Paxillin
- MYD88
- SMAD
- TRAF
- TRAF1
- TRAF2
- TRAF3
- TRAF4
- TRAF5
- TRAF6)
- BIN1
- SH3BP2
- LDB3
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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UpToDate Contents
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English Journal
- Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88.
- Rana RR, Simpson P, Zhang M, Jennions M, Ukegbu C, Spear AM, Alguel Y, Matthews SJ, Atkins HS, Byrne B.SourceDivision of Molecular Biosciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
- Microbial pathogenesis.Microb Pathog.2011 Sep;51(3):89-95. Epub 2011 May 27.
- Recent research has highlighted the presence of Toll/Interleukin 1 receptor (TIR)-domain proteins (Tdps) in a range of bacteria, suggested to form interactions with the human adaptor protein MyD88 and inhibit intracellular signaling from Toll-like receptors (TLRs). A Tdp has been identified in Yersi
- PMID 21640812
- Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum.
- Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P.SourceCenter for Molecular Medicine, Karolinska Institute, 17176, Stockholm, Sweden.
- Neuropharmacology.Neuropharmacology.2011 Sep;61(3):442-50. Epub 2011 Feb 12.
- p11 is an adaptor protein which binds to serotonin 5-HT(1B) receptors and 5-HT(4) receptors and regulates their localization at the cell surface. In the present study, we examined to what extent p11 containing neurons co-expressed 5-HT(1B)R and/or 5-HT(4)R in cerebral cortex, hippocampus, cerebellum
- PMID 21300076
Japanese Journal
- Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential
- Takaki Hiromi,Watanabe Yumi,Shingai Masashi,Oshiumi Hiroyuki,Matsumoto Misako,Seya Tsukasa
- Molecular Immunology 48(4), 497-504, 2011-01
- … The overexpression of the wild-type V protein suppressed melanoma differentiation-associated gene 5 (MDA5)-induced IFN-β promoter activity, while this was not seen in A549 cells expressing CD150 transfected with the V protein of the vaccine strain. … The V proteins of the wild-type and vaccine strain did not affect retinoic acid-inducible gene 1 (RIG-I)- or toll-IL-1R homology domain-containing adaptor molecule 1 (TICAM-1)-induced IFN-β promoter activation. …
- NAID 120002834741
- 斎藤 潤
- 日本臨床免疫学会会誌 34(1), 20-28, 2011
- 炎症反応は生体防御において極めて重要な反応であるが,過剰な炎症性応答は組織障害を引き起こす.IL-1βは主要な炎症性サイトカインの一つであり,様々な疾患がIL-1βによって惹起されることが知られている.IL-1βは前駆型のproIL-1βがインフラマソーム(inflammasome)と呼ばれるタンパク複合体により活性型に変換され,細胞外へ分泌される.インフラマソームは刺激を …
- NAID 130000673831
Related Links
- Signalling components Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short lived active complexes in response to an ...
- Adaptor proteins Daniel C Flynn 1,2 1 Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, WV 26506-9300, USA 2 Department of Microbiology, Immunology and Cell Biology, West ...
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- アダプタータンパク質、アダプタータンパク、アダプター蛋白質
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- アダプタータンパク質、アダプター蛋白、アダプタータンパク
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- 英
- adaptor protein
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- アダプタータンパク質、アダプター蛋白、アダプター蛋白質
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- adaptor protein
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- アダプター蛋白、アダプタータンパク、アダプター蛋白質
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Grb10タンパク質、増殖因子受容体結合タンパク質10
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アダプタータンパク質2
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アダプタータンパク質複合体3
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