WordNet

complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
(psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior

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『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/05 15:36:07」(JST)

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Ghon's complex is a lesion seen in the lung that is caused by tuberculosis.^[1]^[2] The lesions consist of a calcified focus of infection and an associated lymph node. These lesions are particularly common in children and can retain viable bacteria, so are sources of long-term infection and may be involved in reactivation of the disease in later life.^[3]

In countries where cow milk infected with Mycobacterium bovis has been eliminated (due to culling of infected cows and pasteurization), primary tuberculosis is usually caused by Mycobacterium tuberculosis and almost always begins in the lungs. Typically, the inhaled bacilli implant in the distal airspaces of the lower part of the upper lobe or the upper part of the lower lobe, usually close to the pleura. As sensitization develops, a 1- to 1.5-cm area of gray-white inflammation with consolidation emerges, known as the Ghon focus. In most cases, the center of this focus undergoes caseous necrosis. Tubercle bacilli, either free or within phagocytes, drain to the regional nodes, which also often caseate. This combination of parenchymal lung lesion and nodal involvement is referred to as the Ghon complex. During the first few weeks there is also lymphatic and hematogenous dissemination to other parts of the body.

In approximately 95% of cases, development of cell-mediated immunity controls the infection.

Differentiation

The Ghon complex undergoes progressive fibrosis, often followed by radiologically detectable calcification ('''Ranke complex'''), and despite seeding of other organs, no lesions develop. Although they are often confused, Ranke complex and Ghon complex are not synonymous. The Ranke complex is an evolution of the Ghon complex (resulting from further healing and calcification of the lesion).^[4]^[5]

The Ghon complex is named after Austrian pathologist Anton Ghon; the Ranke complex is named in honour of German pulmonologist Karl Ernst Ranke.^[6]

References

^ Ghon's primary lesion Whonamedit.com, Accessed 21 January 2008
^ Ober WB (1983). "Ghon but not forgotten: Anton Ghon and his complex". Pathol Annu. 18 Pt 2: 79–85. PMID 6371678.
^ Curvo-Semedo L, Teixeira L, Caseiro-Alves F (2005). "Tuberculosis of the chest". Eur J Radiol 55 (2): 158–72. doi:10.1016/j.ejrad.2005.04.014. PMID 15905057.
^ Robbins and Cotran pathologic basis of disease. – 8th ed. / Vinay Kumar…[et al.] 2010.
^ Robbins and Cotran pathologic basis of disease. – 8th ed. / Anand Athwal…[et al.] 2010.
^ Ghon's primary lesion at Who Named It

UpToDate Contents

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1. 結核の自然史、微生物学、および病因 natural history microbiology and pathogenesis of tuberculosis
2. 結核の皮膚症状 cutaneous manifestations of tuberculosis

English Journal

Modeling nanoparticle delivery of TB drugs to granulomas.

Grobler A1, Perez Sierra Z2, Viljoen HJ3.
Journal of theoretical biology.J Theor Biol.2016 Jan 7;388:85-95. doi: 10.1016/j.jtbi.2015.10.004. Epub 2015 Oct 20.
Tuberculosis, which typically presents as a pulmonary disease, has a complex pathology. The primary site of infection, the Ghon focus, recruits immune cells and a granuloma forms. At earlier stages the granuloma is still vascularized, offering the best opportunity for drug treatment. In the more pro
PMID 26493361

Early events in Mycobacterium tuberculosis infection in cynomolgus macaques.

Lin PL1, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E, Flynn JL.
Infection and immunity.Infect Immun.2006 Jul;74(7):3790-803.
Little is known regarding the early events of infection of humans with Mycobacterium tuberculosis. The cynomolgus macaque is a useful model of tuberculosis, with strong similarities to human tuberculosis. In this study, eight cynomolgus macaques were infected bronchoscopically with low-dose M. tuber
PMID 16790751

Pulmonary tuberculosis in Italian children by age at presentation.

Romano A1, Di Carlo P, Abbagnato L, Salsa L, Mazzola A, Maggio MC, Titone L.
Minerva pediatrica.Minerva Pediatr.2004 Apr;56(2):189-95.
AIM: To evaluate the clinical characteristics, diagnostic methods and outcome of paediatric pulmonary tuberculosis (PTB) in relation to children's ages when observed.METHODS: Children under 15, who had been admitted to the Children's Hospital with PTB were prospectively evaluated. Our sample include
PMID 15249903