WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/25 19:28:15」(JST)

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Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis, periphlebitis retinae, primary perivasculitis of the retina, is an ocular disease characterized by inflammation and possible blockage of retinal blood vessels, abnormal growth of new blood vessels (neovascularization), and recurrent retinal and vitreal hemorrhages.^[1] Eales' disease with a characteristic clinical picture, fluorescein angiographic finding, and natural course and is considered a specific disease entity.

Pathology

It is characterized by three overlapping stages of venous inflammation (vasculitis), occlusion, and retinal neovascularization.

Clinical course

Patients are often asymptomatic in the initial stages of retinal perivasculitis. Some patients may develop symptoms such as floaters, blurring vision, or even gross diminution of vision due to massive vitreous hemorrhage. Vision in these patients can be normal to hand movements or light perception only. Bilaterality is quite common (50–90%) patients.

History

The condition was first described in young adult men by Henry Eales in 1880.^[2] Although men have been reported to have an increased prevalence of Eales disease, one study reported that men and women are affected equally.^[3]

Epidemiology

Eales disease most commonly affects healthy young adults. Male predominance (up to 97.6%) has been reported in a majority of the series. The predominant age of onset of symptoms is between 20 and 30 years. The disease is now seen more commonly in the Indian subcontinent.

Aetiology

The cause of this condition is not known. However in a significant number of patients, DNA of the bacterium Mycobacterium tuberculosis was detected by PCR.^[4]

References

^ Cassin, B. and Solomon, S. Dictionary of Eye Terminology. Gainesville, Florida: Triad Publishing Company, 1990.
^ Elliot, AJ (1954). "Recurrent Intraocular Hemorrhage in Young Adults (Eales's Disease): A Report of Thirty-one Cases". Transactions of the American Ophthalmological Society 52: 811–75. PMC 1312611. PMID 13274441.
^ eMedicine - Eales Disease : Article by Daniel B Roth
^ Madhavan HN, Therese KL, Doraiswamy K (March 2002). "Further investigations on the association of Mycobacterium tuberculosis with Eales' disease". Indian J Ophthalmol 50 (1): 35–9. PMID 12090085.

External links

http://www.whonamedit.com/synd.cfm/1454.html
http://emedicine.medscape.com/article/1225636-overview
http://www.ealesdisease.info

UpToDate Contents

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1. イールズ病 eales disease
2. 原発性眼障害関連の網膜血管炎 retinal vasculitis associated with primary ocular disorders
3. 結核と眼 tuberculosis and the eye
4. 視神経炎：病態生理、臨床的特徴、および診断 optic neuritis pathophysiology clinical features and diagnosis

English Journal

Tubercular retinal vasculitis.

Patricio MS, Portelinha J, Passarinho MP, Guedes ME.SourceDepartment of Ophthalmology, Hospital de Egas Moniz, Lisbon, Portugal. msarapatricio@gmail.com
BMJ case reports.BMJ Case Rep.2013 Jun 3;2013. pii: bcr2013008924. doi: 10.1136/bcr-2013-008924.
Intraocular tuberculosis (TB) infection can have different clinical manifestations including retinal vasculitis. It more frequently involves the veins and is associated with retina haemorrhages and neovascularisation. The diagnosis may be difficult and presumptive being based on clinical findings an
PMID 23737572

Profiling of human leukocyte antigens in Eales disease and tuberculosis.

Cai SJ, Su G, Li H, Xie B, Luo JM.SourceDepartment of Ophthalmology, The Affiliated Hospital of Zunyi Medical College, Zunyi, 563003, China, caishanjun@163.com.
International ophthalmology.Int Ophthalmol.2013 Feb 6. [Epub ahead of print]
To analyze the association between Eales disease, histocompatibility leukocyte antigen alleles (HLA-A/B, HLA-DRB/DQB) and tuberculosis infection, and to explore susceptible genes and protective genes associated with Eales disease and tuberculosis infection in a population of Han nationals from Zunyi
PMID 23386050