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- the 5th letter of the Roman alphabet (同)e
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- (第二次世界大戦および朝鮮戦争の)退役軍人
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/10 23:22:09」(JST)
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- 1. 受動喫煙曝露：小児における影響 secondhand smoke exposure effects in children
- 2. 受動喫煙曝露：成人における影響 secondhand smoke exposure effects in adults
- 3. 間接喫煙曝露の制御 control of secondhand smoke exposure
- 4. 非喫煙者における肺癌 lung cancer in never smokers
- 5. タバコの喫煙と妊娠 cigarette smoking and pregnancy
English Journal
- High SPDEF may identify patients who will have a prolonged response to androgen deprivation therapy.
- Haller AC1, Tan W, Payne-Ondracek R, Underwood W, Tian L, Morrison C, Li F.Author information 1Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, 14263.AbstractBACKGROUND: Due to the indolent nature of prostate cancer, new prognostic measures are needed to identify patients with life threatening disease. SAM pointed domain-containing Ets transcription factor (SPDEF) has been associated with good prognosis and demonstrates an intimate relationship with the androgen receptor (AR), however its role in prostate cancer progression remains unclear.
- The Prostate.Prostate.2014 May;74(5):509-19. doi: 10.1002/pros.22770. Epub 2013 Dec 27.
- BACKGROUND: Due to the indolent nature of prostate cancer, new prognostic measures are needed to identify patients with life threatening disease. SAM pointed domain-containing Ets transcription factor (SPDEF) has been associated with good prognosis and demonstrates an intimate relationship with the
- PMID 24375440
- Cumulative cultural evolution: The role of teaching.
- Castro L1, Toro MA2.Author information 1Centro Asociado de Madrid, UNED, Centro Andrés Manjón, C/Francos Rodríguez 77, 28039 Madrid, Spain. Electronic address: lcastro@madrid.uned.es.2Departamento de Producción Animal, ETS Ingenieros Agrónomos, UPM, Ciudad Universitaria, 28040 Madrid, Spain. Electronic address: miguel.toro@upm.es.AbstractIn humans, cultural transmission occurs usually by cumulative inheritance, generating complex adaptive behavioral features. Cumulative culture requires key psychological processes (fundamentally imitation and teaching) that are absent or impoverished in non-human primates. In this paper we analyze the role that teaching has played in human cumulative cultural evolution. We assume that a system of cumulative culture generates increasingly adaptive behaviors, that are also more complex and difficult to imitate. Our thesis is that, as cultural traits become more complex, cumulative cultural transmission requires teaching to ensure accurate transmission from one generation to the next. In an increasingly complex cultural environment, we consider that individuals commit errors in imitation. We develop a model of cumulative cultural evolution in a changing environment and show that these errors hamper the process of cultural accumulation. We also show that a system of teaching between parents and offspring that increases the fidelity of imitation unblocks the accumulation and becomes adaptive whenever the gain in fitness compensates the cost of teaching.
- Journal of theoretical biology.J Theor Biol.2014 Apr 21;347:74-83. doi: 10.1016/j.jtbi.2014.01.006. Epub 2014 Jan 14.
- In humans, cultural transmission occurs usually by cumulative inheritance, generating complex adaptive behavioral features. Cumulative culture requires key psychological processes (fundamentally imitation and teaching) that are absent or impoverished in non-human primates. In this paper we analyze t
- PMID 24434740
- Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
- De S1, Chan AC2, Coyne HJ 3rd1, Bhachech N3, Hermsdorf U1, Okon M1, Murphy ME2, Graves BJ3, McIntosh LP4.Author information 1Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.2Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.3Department of Oncological Sciences, University of Utah School of Medicine, and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112-5550, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.4Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3. Electronic address: mcintosh@chem.ubc.ca.AbstractDNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited ~50-fold due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR spectroscopy, we demonstrate that this marginally stable helix is unfolded, and not displaced to a non-inhibitory position, when ETV6 is bound to DNA containing a consensus (5')GGAA(3') recognition site. Although significantly lower in affinity, binding to non-specific DNA is auto-inhibited ~5-fold and is also accompanied by helix unfolding. Based on NMR chemical shift perturbations, both specific and non-specific DNA are bound via the same canonical ETS domain interface. However, spectral perturbations are smaller for the non-specific complex, suggesting weaker and less well-defined interactions than in the specific complex. In parallel, the crystal structure of ETV6 bound to a specific DNA duplex was determined. The structure of this complex reveals that a non-conserved histidine residue in the ETS domain recognition helix helps establish the specificity of ETV6 for DNA-binding sites containing (5')GGAA(3')versus(5')GGAT(3'). These studies provide a unified steric mechanism for attenuating ETV6 binding to both specific and non-specific DNA and expand the repertoire of characterized auto-inhibitory strategies utilized to regulate ETS factors.
- Journal of molecular biology.J Mol Biol.2014 Apr 3;426(7):1390-406. doi: 10.1016/j.jmb.2013.11.031. Epub 2013 Dec 12.
- DNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited ~50-fold due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR spectroscopy, we demonstrate that this marginally stable helix is unfolded, and not displaced to a non-inhibitory position,
- PMID 24333486
Japanese Journal
- Influence of Fatigue Loading in Shear Failures of Reinforced Concrete Members without Transverse Reinforcement
- , , , , ,
- Journal of Advanced Concrete Technology 13(5), 263-274, 2015
- Shear fatigue of reinforced concrete members without transverse reinforcement has been observed to be potentially governing for the strength of some structural members subjected to large live loads of …
- NAID 130005073224
- Why Patencies of Femoropopliteal Bypass Grafts with Distal End-to-End Anastomosis are Comparable with End-to-Side Anastomosis
- , , ,
- Annals of Thoracic and Cardiovascular Surgery 21(2), 157-164, 2015
- … Objective: Despite the theoretical favourable hemodynamic advantage of end-to-end anastomosis (ETE), femoropopliteal bypasses with distal ETE and end-to-side anastomosis (ETS) have comparable clinical patencies. …
- NAID 130005065141
- Molecular Mechanisms of the Formation and Progression of Intracranial Aneurysms
- Neurologia medico-chirurgica advpub(0), 2015
- … Decoy oligodeoxynucleotides (ODNs) inhibiting inflammatory transcription factors such as nuclear factor kappa-B (NF-κB) and Ets-1 are the other promising choice of the prevention of IA development. …
- NAID 130004922322
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