- 関
- dyclonine hydrochloride
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English Journal
- Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia.
- Sahdeo S1, Scott BD1, McMackin MZ1, Jasoliya M1, Brown B2, Wulff H2, Perlman SL3, Pook MA4, Cortopassi GA5.
- Human molecular genetics.Hum Mol Genet.2014 Dec 20;23(25):6848-62. doi: 10.1093/hmg/ddu408. Epub 2014 Aug 11.
- Inherited deficiency in the mitochondrial protein frataxin (FXN) causes the rare disease Friedreich's ataxia (FA), for which there is no successful treatment. We identified a redox deficiency in FA cells and used this to model the disease. We screened a 1600-compound library to identify existing dru
- PMID 25113747
- Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells.
- Ju D1, Xie Y1.
- Molecular medicine reports.Mol Med Rep.2014 Nov;10(5):2609-12. doi: 10.3892/mmr.2014.2522. Epub 2014 Aug 28.
- The proteasome has become an important target for cancer therapy with the approval of bortezomib for the treatment of relapsed/refractory multiple myeloma (MM). However, numerous patients with MM do not respond to bortezomib and those responding initially often acquire resistance. Recent clinical st
- PMID 25174315
- Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.
- Wu L1, Liu J, Zhang Y, Hou Y.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Mar 25;62:224-7. doi: 10.1016/j.jpba.2012.01.009. Epub 2012 Jan 16.
- A rapid and sensitive HPLC/MS/MS method was developed and validated for simultaneous determination of tinidazole, dyclonine and chlorhexidine, the three main components of a film-forming solution, in rat plasma. The plasma samples were pretreated by solid phase extraction (SPE) method. Separation wa
- PMID 22305084
Japanese Journal
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