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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/10 07:22:06」(JST)
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| IL7R |
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| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
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3DI2, 3DI3, 3UP1
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| Identifiers |
| Aliases |
IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor |
| External IDs |
MGI: 96562 HomoloGene: 1646 GeneCards: IL7R |
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| Genetically Related Diseases |
| multiple sclerosis, ulcerative colitis, type 1 diabetes mellitus[1] |
| Gene ontology |
| Molecular function |
• antigen binding
• interleukin-7 receptor activity
• protein binding
• cytokine receptor activity
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| Cellular component |
• integral component of membrane
• membrane
• plasma membrane
• extracellular region
• external side of plasma membrane
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| Biological process |
• regulation of cell size
• regulation of DNA recombination
• positive regulation of T cell differentiation in thymus
• homeostasis of number of cells
• cytokine-mediated signaling pathway
• negative regulation of T cell mediated cytotoxicity
• cell growth
• cell surface receptor signaling pathway
• B cell proliferation
• T cell differentiation
• positive regulation of gene expression
• immune response
• cell morphogenesis
• lymph node development
• immunoglobulin production
• signal transduction
• interleukin-7-mediated signaling pathway
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| Sources:Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) |
Chr 5: 35.85 – 35.88 Mb |
Chr 15: 9.51 – 9.53 Mb |
| PubMed search |
[2] |
[3] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.[4][5]
IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin (TSLP) receptors.
References
- ^ "Diseases that are genetically associated with IL7R view/edit references on wikidata".
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ "Entrez Gene: IL7R interleukin 7 receptor".
- ^ Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865.
Further reading
- Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells.". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848.
- Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis.". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077.
- Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.". Histol. Histopathol. 18 (3): 911–23. PMID 12792903.
- Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841.
- Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.". Leukemia. 6 (7): 662–8. PMID 1378163.
- Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13.". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235.
- Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.". Mol. Cell. Biol. 11 (6): 3052–9. PMC 360143. PMID 2038316.
- Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7.". J. Immunol. 153 (1): 97–109. PMID 7515933.
- van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.". Leukemia. 10 (8): 1317–25. PMID 8709637.
- Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.". Cell. 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624.
- Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.". Nature. 391 (6670): 904–7. doi:10.1038/36122. PMID 9495344.
- Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216.
- Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.". Immunity. 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656.
- Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271.
- Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.". Blood. 96 (8): 2803–7. PMID 11023514.
- Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.
External links
- IL7R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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| Other |
|
|
|
| TNF receptor |
| 1-10 |
- TNFR1 (TNFRSF1A)
- TNFR2 (TNFRSF1B)
- LTBR (TNFRSF3)
- CD134 (TNFRSF4)
- CD40 (TNFRSF5)
- Fas receptor (TNFRSF6)
- DcR3 (TNFRSF6B)
- CD27 (TNFRSF7)
- CD30 (TNFRSF8)
- CD137 (TNFRSF9)
|
|
| 11-20 |
- DR4 (TNFRSF10A)
- DR5 (TNFRSF10B)
- DcR1 (TNFRSF10C)
- DcR2 (TNFRSF10D)
- RANK (TNFRSF11A)
- Osteoprotegerin (TNFRSF11B)
- TweakR (TNFRSF12A)
- TACI (TNFRSF13B)
- BAFFR (TNFRSF13C)
- HVEM (TNFRSF14)
- NGFR (TNFRSF16)
- BCMA (TNFRSF17)
- GITR (TNFRSF18)
- TAJ/TROY (TNFRSF19)
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| 21-27 |
- DR6 (TNFRSF21)
- DR3 (TNFRSF25)
- EDA2R (TNFRSF27)
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| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
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| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
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| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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| Other |
- hormone receptor: GH
- prolactin
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| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
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| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
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| IL 17 family |
- IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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| S/T |
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Cluster of differentiation by lineage
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| Lymphoid |
| B cell |
- Pre-B cell: CD10/CALLA
- CD79A
- mature: CD19
- CD20
- CD21/CR2
- CD23/FcεRII
- CD127
- CD40
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| T/NK |
| T cell |
- CD1
- CD4
- CD8
- CD13
- CD18
- CD26
- CD27
- CD28
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| NK cell |
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| All |
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| All |
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| Myeloid |
CFU-GM/
Myelomonocyte |
- CD11c
- CD14
- CD15
- CD31
- CD64
- CD68
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| MEP |
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| All (pan-myeloid) |
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| Stem cell |
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Interleukin receptor modulators
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| IL-1 |
- Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
- Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
- Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
- Decoy receptors: Rilonacept (IL-1 Trap)
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| IL-2 |
- Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
- Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
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| IL-3 |
- Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
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| IL-4 |
- Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
- Antibodies: Dupilumab
- Pascolizumab
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| IL-5 |
- Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
- Antisense oligonucleotides: TPI ASM8
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| IL-6 |
- Agonists: Atexakin alfa
- Interleukin 6
- Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
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| IL-7 |
|
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| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
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| IL-9 |
|
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| IL-10 |
- Agonists: Ilodecakin
- Interleukin 10 (CSIF)
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| IL-11 |
- Agonists: Interleukin 11 (AGIF)
- Oprelvekin
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| IL-12 |
- Agonists: Edodekin alfa
- Interleukin 12
- Antibodies: Briakinumab
- Ustekinumab
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| IL-13 |
- Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
- Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
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| IL-15 |
- Agonists: ALT-803
- Interleukin 15
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| IL-17 |
- Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
- Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
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| IL-18 |
- Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
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| IL-20 |
- Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
- Antibodies: Fletikumab (against IL-20)
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| IL-21 |
- Agonists: Denenicokin
- Interleukin 21
- Antibodies: NNC0114-0005
- NNC0114-0006
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| IL-22 |
- Antibodies: Fezakinumab (against IL-22)
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| IL-23 |
- Agonists: Interleukin 23 (SGRF)
- Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
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| IL-27 |
- Agonists: Interleukin 27 (interleukin 30)
|
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| IL-28 |
- Agonists: Interferon λ4 (IFN-λ4)
- Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
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| IL-31 |
|
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| IL1RL1 |
|
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| IL1RL2 |
- Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
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| Others |
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JAK
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Others
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- Interleukin 14 (taxilin alpha, HMW-BCGF)
- Interleukin 16 (signals through CD4)
- Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
- Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
- Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
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|
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- See also: Cytokine receptor modulators
- Peptide receptor modulators
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UpToDate Contents
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English Journal
- Effects of Different Antigenic Stimuli on Thymic Function and Interleukin-7/CD127 System in Patients with Chronic HIV Infection.
- Castro P1, Torres B, López A, González R, Vilella A, Nicolas JM, Gallart T, Pumarola T, Sánchez M, Leal M, Vallejo A, Bayas JM, Gatell JM, Plana M, García F.
- Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2014 Aug 15;66(5):466-72. doi: 10.1097/QAI.0000000000000207.
- BACKGROUND: We tested if an increase in immune activation and a decrease in CD4 T cells induced by different antigenic stimuli could be associated with changes in the thymic function and the interleukin (IL)-7/CD127 system.METHODS: Twenty-six HIV-infected patients under combined antiretroviral thera
- PMID 24820104
- Inflammatory Cytokines Drive CD4+ T-Cell Cycling and Impaired Responsiveness to Interleukin 7: Implications for Immune Failure in HIV Disease.
- Shive CL1, Mudd JC1, Funderburg NT2, Sieg SF1, Kyi B1, Bazdar DA1, Mangioni D3, Gori A3, Jacobson JM4, Brooks AD5, Hardacre J6, Ammori J6, Estes JD7, Schacker TW8, Rodriguez B1, Lederman MM1.
- The Journal of infectious diseases.J Infect Dis.2014 Aug 15;210(4):619-29. doi: 10.1093/infdis/jiu125. Epub 2014 Feb 28.
- BACKGROUND: Systemic inflammation has been linked to a failure to normalize CD4(+) T-cell numbers in treated human immunodeficiency virus (HIV) infection. Although inflammatory cytokines such as interleukin 6 (IL-6) are predictors of disease progression in treated HIV infection, it is not clear how
- PMID 24585897
- Cross-talk Between RORγt+ Innate Lymphoid Cells and Intestinal Macrophages Induces Mucosal IL-22 Production in Crohn's Disease.
- Mizuno S1, Mikami Y, Kamada N, Handa T, Hayashi A, Sato T, Matsuoka K, Matano M, Ohta Y, Sugita A, Koganei K, Sahara R, Takazoe M, Hisamatsu T, Kanai T.
- Inflammatory bowel diseases.Inflamm Bowel Dis.2014 Aug;20(8):1426-34. doi: 10.1097/MIB.0000000000000105.
- BACKGROUND: Interleukin (IL)-22-producing RORγt innate lymphoid cells (ILCs) play a pivotal role in intestinal immunity. Recent reports demonstrated that ILCs contribute to mucosal protection and intestinal inflammation in mice. In humans, numbers of RORγt ILCs are significantly increased in the i
- PMID 24991784
Japanese Journal
- SF-044-2 CD4^+CD25^<high>CD127^<low/->制御性T細胞は,乳癌患者末梢血中に増加し,免疫応答を抑制する(SF-044 サージカルフォーラム(44)乳腺:基礎-1,第111回日本外科学会定期学術集会)
- 酒村 智子,井本 滋,伊東 大樹,伊美 建太郎,伊坂 泰嗣,田崎 英里,宮本 快介,和田 徳昭,嶋田 俊之,麻賀 創太,山内 稚佐子,中面 哲也
- 日本外科学会雑誌 112(臨時増刊号_1・2), 390, 2011-05-25
- NAID 110008683873
- IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice
- Yoshizawa Katsumi,Nakajima Shinsuke,Notake Tsuyoshi,Miyagawa Shin-Ichi,Hida Shigeaki,Taki Shinsuke
- JOURNAL OF IMMUNOLOGY 187(10), 5162-5169, 2011
- … Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. …
- NAID 120004724758
- CD4+CD25(high)CD127(low/-) Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis.
- Kawashiri Shin-Ya,Kawakami Atsushi,Okada Akitomo,Koga Tomohiro,Tamai Mami,Yamasaki Satoshi,Nakamura Hideki,Origuchi Tomoki,Ida Hiroaki,Eguchi Katsumi
- The Journal of Rheumatology 38(12), 2517-2521, 2011
- To investigate whether the frequency of peripheral blood (PB) regulatory T cells (Treg) correlates with the clinical disease activity of rheumatoid arthritis (RA).
- NAID 120003751866
Related Links
- CD127抗原は、ヒトIL-7レセプタのα鎖です。分子量は75-80kDで、正常なB前駆細胞にみられますが、成熟B細胞にはありません。また、大半のT細胞や、単球のサブセット、CD34+細胞のサブセットにも発現します。CD127分子は、CD132 ...
- Treg Detection Kit (CD4/CD25/CD127) は、フローサイトメトリーによる制御性T細胞 (Treg) 検出の際に、一度のピペッティングで簡単に染色できる試薬として開発されました。以下のアプリケーションが含まれています。末梢単核球、除去療法や ...
Related Pictures
★リンクテーブル★
[★]
- 英
- interleukin-7
- 関
- サイトカイン、インターロイキン
- B細胞系列の分化に必要。multipotent progenitor cellからcommon lymphoid progenitorに分化したときにはIL-7受容体を発現しており、骨髄間質細胞から分泌されるIL-7によって増殖が維持される。けどマウスだけでヒトでは違うらしい？
- IL-7が過剰発現すると自己免疫疾患になる。炎症性腸疾患 inflammatory bowel disease
産生細胞
機能
受容体
[★]
- 同
- leucine-6, CD1A through E
種類
発現組織
- 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)
分子量
機能
- MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens