WordNet
- the 2nd letter of the Roman alphabet (同)b
- the blood group whose red cells carry the B antigen (同)type_B, group B
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/26 18:59:21」(JST)
wiki ja
wiki en
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 赤血球産生調節 regulation of erythropoiesis
- 2. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
- 3. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
- 4. Chapter 6J：エリスロポエチン chapter 6j erythropoietin
- 5. 後天性赤芽球癆 acquired pure red cell aplasia
English Journal
- Safety analysis of sport in Switzerland.
- Brügger O.Author information bfu - Swiss Council for Accident Prevention, Berne, Switzerland.AbstractBACKGROUND: Every year, around 400 000 Swiss residents are injured in sports accidents so severely that they need medical treatment. 170 people suffer fatal sports accidents in Switzerland. The bfu-Swiss Council for Accident Prevention-is legally mandated to prevent sports injuries.
- British journal of sports medicine.Br J Sports Med.2014 Apr;48(7):575. doi: 10.1136/bjsports-2014-093494.42.
- BACKGROUND: Every year, around 400 000 Swiss residents are injured in sports accidents so severely that they need medical treatment. 170 people suffer fatal sports accidents in Switzerland. The bfu-Swiss Council for Accident Prevention-is legally mandated to prevent sports injuries.OBJECTIVE: The
- PMID 24620083
- Tight Regulation of a Timed Nuclear Import Wave of EKLF by PKCθ and FOE during Pro-E to Baso-E Transition.
- Shyu YC1, Lee TL2, Chen X2, Hsu PH3, Wen SC2, Liaw YW2, Lu CH2, Hsu PY2, Lu MJ2, Hwang J2, Tsai MD4, Hwang MJ5, Chen JR6, Shen CK7.Author information 1Institute of Biopharmaceutical Sciences, National Yang-Ming University, Beitou, Taipei 112, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, Da'an, Taipei 103, Taiwan, ROC; Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan 115, ROC. Electronic address: ycshyu@ym.edu.tw.2Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan 115, ROC.3The Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC.4Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC.5Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC.6Department of Pathology, Keelung Chang Gung Memorial Hospital, Anle, Keelung 204, Taiwan, ROC; College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan 259, Taiwan, ROC.7Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan 115, ROC. Electronic address: ckshen@imb.sinica.edu.tw.AbstractErythropoiesis is a highly regulated process during which BFU-E are differentiated into RBCs through CFU-E, Pro-E, PolyCh-E, OrthoCh-E, and reticulocyte stages. Uniquely, most erythroid-specific genes are activated during the Pro-E to Baso-E transition. We show that a wave of nuclear import of the erythroid-specific transcription factor EKLF occurs during the Pro-E to Baso-E transition. We further demonstrate that this wave results from a series of finely tuned events, including timed activation of PKCθ, phosphorylation of EKLF at S68 by P-PKCθ(S676), and sumoylation of EKLF at K74. The latter EKLF modifications modulate its interactions with a cytoplasmic ankyrin-repeat-protein FOE and importinβ1, respectively. The role of FOE in the control of EKLF nuclear import is further supported by analysis of the subcellular distribution patterns of EKLF in FOE-knockout mice. This study reveals the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors.
- Developmental cell.Dev Cell.2014 Feb 24;28(4):409-22. doi: 10.1016/j.devcel.2014.01.007.
- Erythropoiesis is a highly regulated process during which BFU-E are differentiated into RBCs through CFU-E, Pro-E, PolyCh-E, OrthoCh-E, and reticulocyte stages. Uniquely, most erythroid-specific genes are activated during the Pro-E to Baso-E transition. We show that a wave of nuclear import of the e
- PMID 24576425
- Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions.
- Cui R1, Gale RP2, Zhu G3, Xu Z1, Qin T1, Zhang Y4, Huang G5, Li B1, Fang L1, Zhang H1, Pan L1, Hu N1, Qu S1, Xiao Z6.Author information 1MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.2Imperial College London, London, United Kingdom.3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.4MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.5Division of Pathology & Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.6MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. Electronic address: zjxiao@hotmail.com.AbstractDysregulation of hepcidin, a key iron regulating hormone, is important in the pathogenesis of iron overload in patients with myelodysplatic syndrome (MDS). However, most studies of hepcidin levels are complicated by concomitant RBC transfusions. To evaluate the relationship between iron metabolism and erythropoiesis, we measured serum levels of hepcidin, growth-differentiation factor-15 (GDF15) and other markers of erythropoiesis in 107 subjects with MDS not receiving RBC transfusions. Patients with MDS had significantly higher levels of hepcidin than normals. However, their hepcidin-ferritin ratio was markedly decreased compared to normals (P<0.001) and varied substantially between MDS subtypes (P=0.011). GDF15 levels positively correlated with percent of bone marrow erythroblasts (P<0.001), soluble transferrin receptor (sTfR) (P=0.018), and also with transferrin saturation (ISAT) (P=0.038). The hepcidin-ferritin ratio negatively correlated with serum erythropoietin (EPO) levels (P<0.001), and also with GDF15 levels (P=0.014). Colony forming cells (CFC) were evaluated in 70 subjects. Those with serum ferritin (SF) levels <500ng/ml had significantly more BFU-E than subjects with SF≥500ng/L (P=0.007), but numbers of granulocyte/macrophage-colony-forming cells (CFU-GM) were similar (P=0.190). Our data indicate serum hepcidin levels are inappropriately low in patients MDS not receiving RBC transfusions. GDF15 levels correlated with low hepcidin levels and may contribute to iron overload in this setting. Iron overload may in turn suppress erythropoiesis by imparing the proliferative capacity of the erythroid progenitor cells.
- Leukemia research.Leuk Res.2014 Feb 10. pii: S0145-2126(14)00036-8. doi: 10.1016/j.leukres.2014.01.016. [Epub ahead of print]
- Dysregulation of hepcidin, a key iron regulating hormone, is important in the pathogenesis of iron overload in patients with myelodysplatic syndrome (MDS). However, most studies of hepcidin levels are complicated by concomitant RBC transfusions. To evaluate the relationship between iron metabolism a
- PMID 24598841
Japanese Journal
- 多彩な感染症状を呈した好中球減少症
- 日下 さやか,飯塚 浩光,西山 小百合 [他],阿部 有,関根 理恵子,中川 靖章,鈴木 憲史,井上 荘太郎
- 日本内科学会雑誌 101(1), 150-153, 2012-01-10
- … 周期性好中球減少症は原因不明なまれな疾患である1）．症例は70歳女性．周期性は明らかではなかったが2），ステロイドの減量に伴い冬季に好中球数が減少し感染を繰り返した．CFU-E+BFU-Eは正常であったが，CFU-GM，CFU-GEMMが低値，またG-CSF受容体数は著明に低下していた．深在性真菌感染症や白内障などの合併症が出現し，現在はG-CSF単独療法中である． …
- NAID 10030391393
- Differences in the JAK2 and MPL Mutation Status in the Cell Lineages of the bcr/abl-negative Chronic Myeloproliferative Neoplasm Subtypes
- Toyama Kohtaro,Karasawa Masamitsu,Yokohama Akihiko,Mitsui Takeki,Uchiumi Hideki,Saitoh Takayuki,Handa Hiroshi,Murakami Hirokazu,Nojima Yoshihisa,Tsukamoto Norifumi
- Internal Medicine 50(21), 2557-2561, 2011
- … Methods The mutation status of these genes in granulocytes, platelets, T-cells, and erythroid colonies (BFU-E) was obtained from 115 MPN patients, and then the clinical features of the MPN subtypes were compared. … Results The JAK2-V617F mutation was observed in three lineages of granulocytes, platelets, and BFU-E in almost all polycythemia vera (PV) and primary myelofibrosis (PMF) patients. …
- NAID 130001288611
- Relationship between Radiosensitivity of Human Neonatal Hematopoietic Stem/Progenitor Cells and Individual Maternal/Neonatal Obstetric Factors
- Omori Atsuko,Chiba Takako,Kashiwakura Ikuo
- Journal of radiation research 51(6), 755-763, 2010-11-16
- … Freshly prepared CB CD34+ cells exposed to 2 Gy X-irradiation were assayed for hematopoietic progenitor cells such as colony-forming unit-granulocyte-macrophage (CFU-GM), burst-forming unit-erythroid (BFU-E), colony-forming unit-granulocyte-erythroid-macrophage-megakaryocyte (CFU-Mix), and colony-forming unit-megakaryocyte (CFU-Meg). …
- NAID 10026964323
Related Links
- 「筑後の女性はファッションセンスが良いコが多い」という話をよく耳にする。その要因のひとつとなっているのが、筑後エリアで14店舗ものショップを展開しているBFUグループ。この敷地には、3つの店舗が隣接している。
- BFU - いいね！4,896件 · 6人が話題にしています - BFU (Best For You) 香港優質 藍牙耳機品牌 Hong Kong High Quality Wireless BT Headset Brand 明報採訪 Ming Pao Newspaper Interview...
Related Pictures
★リンクテーブル★
| リンク元 | 「burst-forming unit」「バースト形成単位」 |
| 拡張検索 | 「BFU-E」「BFU-MK」 |
| 関連記事 | 「B」 |
「burst-forming unit」
- 関
- BFU
「バースト形成単位」
「BFU-E」
[★] 赤芽球バースト形成細胞 burst-forming units-erythroid
「BFU-MK」
「B」
- 気管分岐部下緑
- 補体のalternative pathwayに関わる蛋白質
- Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する