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English Journal

Natural IgM Prevents Autoimmunity by Enforcing B Cell Central Tolerance Induction.

Nguyen TT1, Elsner RA2, Baumgarth N3.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Jan 16. pii: 1401880. [Epub ahead of print]
It is unclear why selective deficiency in secreted (s)IgM causes Ab-mediated autoimmunity. We demonstrate that sIgM is required for normal B cell development and selection. The CD5+ B cells that were previously shown to accumulate in body cavities of sIgM-/- mice are not B-1a cells, but CD19int, CD4
PMID 25595791

Shaikh SR1, Haas KM, Beck MA, Teague H.
Clinical and experimental immunology.Clin Exp Immunol.2015 Jan;179(1):90-9. doi: 10.1111/cei.12444.
B-1 and B-2 B cell subsets carry out a diverse array of functions that range broadly from responding to innate stimuli, antigen presentation, cytokine secretion and antibody production. In this review, we first cover the functional roles of the major murine B cell subsets. We then highlight emerging
PMID 25169121

Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis.

Zhang J1, Jia G, Liu Q, Hu J, Yan M, Yang B, Yang H, Zhou W, Li J.
Immunology.Immunology.2015 Jan;144(1):56-67. doi: 10.1111/imm.12347.
MicroRNAs have been shown to be important regulators of immune homeostasis as patients with aberrant microRNA expression appeared to be more susceptible to autoimmune diseases. We recently found that miR-146a was up-regulated in activated B cells in response to rat acetylcholine receptor (AChR) α-s
PMID 24962817

Dual Protective Effects of Flavonoids from Petasites japonicus against UVB-Induced Apoptosis Mediated via HSF-1 Activated Heat Shock Proteins and Nrf2-Activated Heme Oxygenase-1 Pathways