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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/01 15:04:11」(JST)

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English Journal

Challenges and opportunities for bacterial vaccine development in the 21(st) century.

Duvvuri VR, Barreto L, Wu J, Tsang RS1.
Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(8):758-67.
With the convergence of modern technology in genomics, proteomics, carbohydrate, protein and lipid biochemistry as well as decades of experience in vaccine development and delivery of immunization programs, the Global Vaccine Action Plan has declared 2011 to 2020 as 'The Decade of Vaccines'. This re
PMID 24180307

HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer.

Jung KH1, Yan HH1, Fang Z1, Son MK1, Lee H1, Hong S2, Hong SS1.
International journal of oncology.Int J Oncol.2014 Jul;45(1):311-21. doi: 10.3892/ijo.2014.2435. Epub 2014 May 9.
Gemcitabine has limited clinical benefits for pancreatic cancer patients. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is important in cell proliferation and survival, and is frequently dysregulated in pancreatic cancer. To obtain insights into novel therapeutic strategies for trea
PMID 24819705

Preparation, optimization and invitro characterization of stearoyl-gemcitabine polymeric micelles: A comparison with its self-assembled nanoparticles.

Daman Z1, Ostad S2, Amini M3, Gilani K4.
International journal of pharmaceutics.Int J Pharm.2014 Jul 1;468(1-2):142-51. doi: 10.1016/j.ijpharm.2014.04.021. Epub 2014 Apr 13.
Although gemcitabine (Gem) constitutes first-line therapy for pancreatic cancer, its clinical outcome suffers from rapid metabolism and acquired drug resistance. To overcome its limitations, several lipophilic prodrugs including 4-(N)-stearoyl Gem (GemC18) have been studied for their efficacy over G
PMID 24731731

Japanese Journal

がん耐性因子を標的とした抗がん剤の耐性克服 : 温故知新 : グルタチオンおよびグリオキサラーゼIを標的とした耐性克服研究

安井英子,加藤國基
有機合成化学協会誌 70(3), 240-249, 2012-03-01
… AsPC-1 cells show the drug-resistance against anticancer drugs because of the over-expression of GSH. … When AsPC-1 cells were treated with several anticancer drugs in the presence of COTC, the sensitivity of AsPC-1 cells to CDDP and melphalan was significantly increased. …
NAID 10030481690

Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.

Sasaki Naoya,Ishii Takamichi,Kamimura Ryo,Kajiwara Masatoshi,Machimoto Takafumi,Nakatsuji Norio,Suemori Hirofumi,Ikai Iwao,Yasuchika Kentaro,Uemoto Shinji
Cancer letters 308(2), 152-161, 2011-09-28
… Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. …
NAID 120003290284

Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells

Mitsuoka Keisuke,Kato Yukio,Miyoshi Sosuke,Murakami Yoshihiro,Hiraiwa Mariko,Kubo Yoshiyuki,Nishimura Shintaro,Tsuji Akira
European Journal of Pharmaceutical Sciences 40(3), 202-208, 2010-06
… We here synthesized two novel dipeptides, l-phenylalanyl sarcosine (Phe-Sar) and 4-(4-methoxyphenyl)-l-phenylalanyl sarcosine (Bip(OMe)-Sar), and examined their effect on the growth of human pancreatic cancer AsPC-1 cells, which are known to highly express oligopeptide transporter PEPT1/SLC15A1. … Growth of AsPC-1 cells was inhibited by these two peptides and a typical PEPT1/SLC15A1 substrate Gly-Sar. …
NAID 120002224386

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