日
関

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/26 15:37:26」(JST)

wiki en

For the degradation product of glyphosphate also known as AMPA, see aminomethylphosphonic acid.

AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.^[1]

There are two types of Ionotropic glutamate receptors that are ligand gated ion channels whose agonists include AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA). In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.^[2] AMPA generates fast excitatory postsynaptic potentials (EPSP).^[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na⁺ and K⁺ and therefore have an equilibrium potential near 0 mV.

References

^ ^a ^b Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed.. Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.
^ Dinh, L; Nguyen T, Salgado H, Atzori M (2009). "Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat". Neurochem Res 34 (11): 1896–906. doi:10.1007/s11064-009-9966-z. PMID 19357950.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 腫瘍随伴性および自己免疫性脳炎 paraneoplastic and autoimmune encephalitis
2. 筋萎縮性側索硬化症の疫学および病因 epidemiology and pathogenesis of amyotrophic lateral sclerosis
3. 小児および思春期における脆弱X症候群のマネージメント management of children and adolescents with fragile x syndrome
4. 新生児脳症の病因および発症機序 etiology and pathogenesis of neonatal encephalopathy
5. 肝性脳症の病因 pathogenesis of hepatic encephalopathy

English Journal

Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding.

Peng XX1, Lister A1, Rabinowitsch A1, Kolaric R1, Cabeza de Vaca S1, Ziff EB2, Carr KD3.
Neuroscience.Neuroscience.2015 Jun 4;295:58-71. doi: 10.1016/j.neuroscience.2015.03.025. Epub 2015 Mar 20.
Weight-loss dieting often leads to loss of control, rebound weight gain, and is a risk factor for binge pathology. Based on findings that food restriction (FR) upregulates sucrose-induced trafficking of glutamatergic AMPA receptors to the nucleus accumbens (NAc) postsynaptic density (PSD), this stud
PMID 25800309

Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus.

Xie M1, Yan J1, He C1, Yang L1, Tan G1, Li C1, Hu Z2, Wang J3.
Behavioural brain research.Behav Brain Res.2015 Jun 1;286:64-70. doi: 10.1016/j.bbr.2015.02.040. Epub 2015 Feb 27.
Hippocampus-dependent learning memory is sensitive to sleep deprivation (SD). Although the ionotropic glutamate receptors play a vital role in synaptic plasticity and learning and memory, however, whether the expression of these receptor subunits is modulated by sleep loss remains unclear. In the pr
PMID 25732956

Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.

Byers CE1, Barylko B1, Ross JA2, Southworth DR3, James NG2, Taylor CA 4th1, Wang L1, Collins KA4, Estrada A1, Waung M4, Tassin TC1, Huber KM4, Jameson DM2, Albanesi JP5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun;1850(6):1310-8. doi: 10.1016/j.bbagen.2015.03.002. Epub 2015 Mar 14.
BACKGROUND: The Activity-regulated cytoskeleton-associated protein, Arc, is an immediate-early gene product implicated in various forms of synaptic plasticity. Arc promotes endocytosis of AMPA type glutamate receptors and regulates cytoskeletal assembly in neuronal dendrites. Its role in endocytosis
PMID 25783003

Japanese Journal

Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference

Shinohara Fumiya,Kihara Yukari,Ide Soichiro,Minami Masabumi,Kaneda Katsuyuki
Neuropharmacology 79, 573-579, 2014-04
… Intra-LDT injection of carbachol, which hyperpolarizes LDT neurons, and of NMDA and AMPA receptor antagonists before cocaine conditioning blocked and attenuated cocaine CPP, respectively, indicating the necessity of LDT activity for acquiring the CPP. …
NAID 120005367413

1-(1,3-Benzodioxol-5-yl-carbo-nyl) Piperidine, a Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic Acid Receptor, Ameliorates Exercise-Induced Fatigue in Mice

Fan Wutu,Wu Xianglong,Pan Yalei [他],Li Chenrui,Niu Yinbo,Zhai Yuankun,Mei Qibing
Biological and Pharmaceutical Bulletin, 13-17, 2014
… Therefore, this study demonstrated for the first time that the supplementation of 1-BCP, as a positive allosteric modulator of AMPA receptor, could enhance the endurance capacity of mice and facilitated them recovery from fatigue. …
NAID 130003382112

大脳皮質における興奮性神経回路の睡眠 : 覚醒状態依存的変化 (MEとバイオサイバネティックス)

中村有孝,辛島彰洋,坪川宏 [他]
電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 113(314), 1-6, 2013-11-22
NAID 40019909711

Related Pictures

★リンクテーブル★

リンク元	「alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid」「α-アミノ-3-ヒドロキシ-5-メチル-4-イソキサゾールプロピオン酸」
拡張検索	「AMPA型グルタミン酸受容体」「AMPAレセプター」「AMPA receptor」
関連記事	「AM」「AMP」

「alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid」

AMPA
	IUPAC name 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
Identifiers
CAS number	77521-29-0
PubChem	1221
ChemSpider	1184
DrugBank	DB02057
KEGG	C11033
MeSH	AMPA
ChEMBL	CHEMBL276815
Jmol-3D images	Image 1
	SMILES O=C1/C(=C(\ON1)C)CC(N)C(=O)O ;
	InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) ; Key: UUDAMDVQRQNNHZ-UHFFFAOYSA-N InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12); Key: UUDAMDVQRQNNHZ-UHFFFAOYAT ;
Properties
Molecular formula	C7H10N2O4
Molar mass	186.17 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references