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- 5-aminolevulinic acid synthase-1
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- Alabama
- ああ,あわれ(悲しみ・後悔などを表す声)
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- 1. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias
- 2. 骨髄性プロトポルフィリン症 erythropoietic protoporphyria
- 3. ポルフィリン症：概要 porphyrias an overview
- 4. 急性間欠性ポルフィリン症の病因および発症機序 etiology and pathogenesis of acute intermittent porphyria
- 5. ALA脱水酵素欠損性ポルフィリン症 ala dehydratase porphyria
English Journal
- Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.
- Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL.SourceLiver, Digestive, and Metabolic Disorders Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28203, USA.
- The Journal of biological chemistry.J Biol Chem.2011 Jul 29;286(30):26424-30. Epub 2011 Jun 9.
- 5-Aminolevulinic acid synthase (ALAS-1) is the first rate controlling enzyme that controls cellular heme biosynthesis. Negative feedback regulation of ALAS-1 by the end product heme is well documented and provides the foundation for heme treatment of acute porphyrias, a group of diseases caused by g
- PMID 21659532
- PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha.
- Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y.SourceThe National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
- Mitochondrion.Mitochondrion.2010 Aug;10(5):516-27. Epub 2010 May 31.
- The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1 beta (PGC-1 beta) is a well-established regulator of the beta-oxidation of fatty acids and the oxidative phosphorylation in mitochondria. However, the underlying mechanism of PGC-1 beta action remains elusive. This study
- PMID 20561910
Japanese Journal
- 遺伝子発現調節のリガンドとしてのヘムの機能
- 竹谷 茂
- ビタミン 84(3), 123-127, 2010-03-25
- NAID 110007575064
- Haeme-regulated Degradation of δ-Aminolevulinate Synthase 1 in Rat Liver Mitochondria
- YOSHINO Kazuhisa,MUNAKATA Hiroshi,KUGE Osamu,ITO Akio,OGISHIMA Tadashi
- The journal of biochemistry 142(4), 453-458, 2007-10-01
- NAID 10020095960
Related Links
- Complete information for ALAS1 gene (protein-coding), aminolevulinate, delta-, synthase 1.
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[★] 5-アミノレブリン酸 5-aminolevulinate
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- 8-aminolevulinic acid synthase