in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini
English Journal
Orphan macrodomain (human C6ORF130) is an o-acyl-ADP-ribose deacylase: solution structure and catalytic properties.
Peterson FC, Chen D, Lytle BL, Rossi MN, Ahel I, Denu JM, Volkman BF.SourceMedical College of Wisconsin, United States;
The Journal of biological chemistry.J Biol Chem.2011 Aug 17. [Epub ahead of print]
Post-translational modification of proteins/histones by lysine acylation has profound effects on the physiological function of modified proteins. Deacylation by NAD+ dependent sirtuin reactions yields O-acyl-ADP-ribose as a product, which has been implicated as a signaling molecule in modulating cel
Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.
Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y.SourceGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai 319-1195, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Graduate School of Science and Engineering, Ehime University, Matsuyama 790-8577, Fukuoka Dental College, Fukuoka 814-0913 and Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-8556, Japan.
Human NUDT5 (hNUDT5) hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR). However, the structural basis of the broad substrate specificity remains unknown. Here, we report the crystal structures of hNUDT5 complexed with 8-oxo-dGDP and 8-oxo-dADP
Journal of pharmacological sciences 101(1), 66-76, 2006-05-20
… We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR). … ADPR-induced current responses, H2O2-induced Ca2+ influx, and H2O2-induced cell death were induced in human embryonic kidney cells heterologously expressing rat TRPM2. …