adenosine diphosphate ribose

• アデノシン二リン酸リボース、ADPリボース

関

adenosine diphosphoribose、ADP-ribose、ADPR

WordNet

1. a pentose sugar important as a component of ribonucleic acid
2. (biochemistry) a nucleoside that is a structural component of nucleic acids; it is present in all living cells in a combined form as a constituent of DNA and RNA and ADP and ATP and AMP

PrepTutorEJDIC

1. リボース(リボ核酸の加水分解によって得られる五炭糖)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/28 10:06:10」(JST)

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[Wiki en表示]

Adenosine diphosphate ribose

Names
Other names ADP ribose
Identifiers
CAS Registry Number	20762-30-5 N
ChEMBL	ChEMBL1161865 N
ChemSpider	388340 N
InChI InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1 N Key: YNCNQNWXUFCWJS-DKMYFHGXSA-O N InChI=1/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1 Key: YNCNQNWXUFCWJS-LKOYDKQFBH
Jmol-3D images	Image
MeSH	Adenosine+Diphosphate+Ribose
PubChem	439200
SMILES O=P(O[C@H]1O[C@H]([C@H](O)[C@@H]1O)CO)(O)OP(=O)(OC[C@H]4O[C@@H]([n+]3c2ncnc(N)c2nc3)[C@H](O)[C@@H]4O)O
Properties
Chemical formula	C15H23N5O14P2
Molar mass	559.316 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. It binds to and activates the TRPM2 ion channel.

See also

• Adenosine diphosphate
• Ribose

References

UpToDate Contents

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• 1. ER／PR陰性、HER2陰性（トリプルネガティブ）乳癌の疫学、危険因子および臨床的アプローチ epidemiology risk factors and the clinical approach to er pr negative her2 negative triple negative breast cancer
• 2. 止血の概要 overview of hemostasis
• 3. 血小板生物学 platelet biology
• 4. 心不全における骨格筋機能低下および運動耐容能低下 skeletal muscle dysfunction and exercise intolerance in heart failure
• 5. 血小板機能検査 platelet function testing

English Journal

• PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.

• Ghonim MA1, Pyakurel K2, Ibba SV2, Wang J2, Rodriguez P3, Al-Khami AA4, Lammi MR5, Kim H2, Zea AH6, Davis C2, Okpechi S2, Wyczechowska D2, Al-Ghareeb K7, Mansy MS7, Ochoa A2, Naura AS2, Boulares AH8.
• Clinical science (London, England : 1979).Clin Sci (Lond).2015 Dec;129(11):951-62. doi: 10.1042/CS20150122. Epub 2015 Jul 23.
• Our laboratory established a role for poly(ADP-ribose)polymerase (PARP) in asthma. To increase the clinical significance of our studies, it is imperative to demonstrate that PARP is actually activated in human asthma, to examine whether a PARP inhibitor approved for human testing such as olaparib bl
• PMID 26205779

• Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR pathway.

• Li GH1, Lin XL2, Zhang H1, Li S1, He XL1, Zhang K3, Peng J1, Tang YL1, Zeng JF4, Zhao Y1, Ma XF1, Lei JJ1, Wang R1, Wei DH1, Jiang ZS5, Wang Z6.
• Atherosclerosis.Atherosclerosis.2015 Nov;243(1):223-35. doi: 10.1016/j.atherosclerosis.2015.09.020. Epub 2015 Sep 18.
• Oxidised lipoprotein(a) [oxLp(a)] is considered as a more potent arteriosclerotic factor than native Lp(a). However, the molecular mechanisms underlying this potency remain unclear. Reactive oxygen species (ROS) possibly act as intracellular second messengers that participate in autophagy stimulatio
• PMID 26407666

• Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.

• Clark-Matott J1, Saleem A2, Dai Y3, Shurubor Y4, Ma X2, Safdar A3, Beal MF4, Tarnopolsky M2, Simon DK3.
• Neurobiology of aging.Neurobiol Aging.2015 Nov;36(11):2972-83. doi: 10.1016/j.neurobiolaging.2015.07.020. Epub 2015 Jul 21.
• Mitochondrial DNA (mtDNA) mutator mice express a mutated form of mtDNA polymerase gamma that results an accelerated accumulation of somatic mtDNA mutations in association with a premature aging phenotype. An exploratory metabolomic analysis of cortical metabolites in sedentary and exercised mtDNA mu
• PMID 26294258

Japanese Journal

• Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy.

• Ohtsuji Michio,Yagi Kunimasa,Shintaku-Kubota Miyuki,Kojima-Koba Yukiko,Ito Naoko,Sugihara Masako,Yamaaki Naoto,Chujo Daisuke,Nohara Atsushi,Takeda Yoshiyu,Kobayashi Junji,Yamagishi Masakazu,Higashida Haruhiro
• Experimental diabetes research 2008, 89758, 2008-12-00
• … AIMS/HYPOTHESIS: ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5'diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral blood mononuclear cells (PBMCs). …
• NAID 120001491366

• (2)プロゲステロン受容体モデュレーターならびにGnRH antagonistによるヒト子宮筋腫細胞発育制御機構の解析(<特集>第59回シンポジウム1「子宮筋腫の発育制御とその管理」)

• 小原 範之
• 日本産科婦人科學會雜誌 59(9), 1679-1685, 2007-09-01
• … RNA interference of GADD 153 suppressed the levels of asoprisnil-induced poly (adenosine 5'-diphosphate-ribose) polymerase, Bax, and Bak in the cells, and attenuated asoprisnil-induced reduction in Bcl-2 protein content. …
• NAID 110006804498

• Mesentric injury after cardiopulmonary bypass : Role of poly (adenosine 5'-diphosphate-ribose) polymerase

• SZABO G
• Crit Care Med 32, 2392-2397, 2004
• NAID 30009228375

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★リンクテーブル★

リンク元	「ADPリボース」「ADP-ribose」「adenosine diphosphoribose」「アデノシン二リン酸リボース」「ADPR」
拡張検索	「poly adenosine diphosphate ribose」
関連記事	「diphosphate」「ribose」「adenosine diphosphate」

「ADPリボース」

　　[★]

英

adenosine diphosphate ribose、ADP-ribose、ADPR

関

ADP-リボース、アデノシン二リン酸リボース

「ADP-ribose」

　　[★]

• ADPリボース、ADP-リボース

関

adenosine diphosphate ribose、adenosine diphosphoribose、ADPR

「adenosine diphosphoribose」

　　[★]

• アデノシン二リン酸リボース

関

adenosine diphosphate ribose、ADP-ribose

「アデノシン二リン酸リボース」

　　[★]

英

adenosine diphosphate ribose、adenosine diphosphoribose

関

ADPリボース

「ADPR」

　　[★]

• ADPリボース

関

adenosine diphosphate ribose、ADP-ribose

「poly adenosine diphosphate ribose」

　　[★] ポリアデノシン二リン酸リボース

「diphosphate」

　　[★] 二リン酸エステル、二リン酸塩、二リン酸

関

bisphosphate、diphosphoric acid、pyrophosphate

「ribose」

　　[★]

リボース

関

D-ribose

　 　

「adenosine diphosphate」

　　[★] アデノシン二リン酸 ADP