30Sリボソーム
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/02/04 13:31:59」(JST)
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Atomic structure of the 30S Subunit from
Thermus thermophilus. Proteins are shown in blue and the single RNA strand in orange.
[1]
30S is the smaller subunit of the 70S ribosome of prokaryotes. It is a complex of ribosomal RNA and ribonucleoproteins that functions in mRNA translation. It includes the 16S ribosomal RNA. It has about 21 basic proteins.
The 30S subunit is the site of inhibition for antibiotics such as tetracycline and aminoglycosides.
See also
50S is the larger subunit of the 70S ribosome of prokaryotes( in the part 50s indicates synthesis)in the cell. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA.
References
- ^ Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A (2000). "Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution". Cell 102 (5): 615–23. doi:10.1016/S0092-8674(00)00084-2. PMID 11007480.
External links
- 16S rRNA, BioMineWiki
- http://pathmicro.med.sc.edu/mayer/antibiot.htm
- 16S Ribosomal RNA at the US National Library of Medicine Medical Subject Headings (MeSH)
Ribosomal RNA / ribosome subunits
|
|
Prokaryotes (70S) |
- Large
- 50S
- 5S
- 23S
- Small
- 30S
- 16S
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|
Eukaryotes (80S) |
Cytoplasmic
|
- Large
- 60S
- 5S
- 5.8S
- 28S
- Small
- 40S
- 18S
|
|
Mitochondrial
|
- MT-RNR1, 12S
- MT-RNR2, 16S
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|
|
- ''B bsyn: dna
- tscr
- fact
- tcrg
- nucl
- rnat
- rept
- ptts
- tltn
- pttl
- dnab
- stru
|
|
UpToDate Contents
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English Journal
- Mutations of ribosomal protein S5 suppress a defect in late-30S ribosomal subunit biogenesis caused by lack of the RbfA biogenesis factor.
- Nord S1, Bhatt MJ2, Tükenmez H1, Farabaugh PJ2, Wikström PM1.
- RNA (New York, N.Y.).RNA.2015 Aug;21(8):1454-68. doi: 10.1261/rna.051383.115. Epub 2015 Jun 18.
- The in vivo assembly of ribosomal subunits requires assistance by maturation proteins that are not part of mature ribosomes. One such protein, RbfA, associates with the 30S ribosomal subunits. Loss of RbfA causes cold sensitivity and defects of the 30S subunit biogenesis and its overexpression parti
- PMID 26089326
- Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.
- Lupien A1, Gingras H1, Leprohon P1, Ouellette M2.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 Jul 16. pii: dkv211. [Epub ahead of print]
- OBJECTIVES: Tigecycline is a broad-spectrum antibiotic acting at the level of the 30S ribosomal subunit to inhibit translation. While Streptococcus pneumoniae remains susceptible to tigecycline, resistance is beginning to emerge in some species and mainly involves efflux or mutations in ribosome con
- PMID 26183184
- Analysis of r-protein and RNA conformation of 30S subunit intermediates in bacteria.
- Napper N1, Culver GM2.
- RNA (New York, N.Y.).RNA.2015 Jul;21(7):1323-34. doi: 10.1261/rna.048918.114. Epub 2015 May 21.
- The ribosome is a large macromolecular complex that must be assembled efficiently and accurately for the viability of all organisms. In bacteria, this process must be robust and tunable to support life in diverse conditions from the ice of arctic glaciers to thermal hot springs. Assembly of the Smal
- PMID 25999315
Japanese Journal
- 2P137 一分子破断力測定によるリボソーム-mRNA相互作用力の非対称性の解明(核酸-相互作用・複合体,第48回日本生物物理学会年会)
- Tachibana Masatoshi,Masuda Tomoaki,Iizuka Ryo,Funatsu Takashi,Uemura Sotaro
- 生物物理 50(SUPPLEMENT_2), S106, 2010-08-15
- NAID 110008102721
- Towards an Elucidation of the Roles of the Ribosome during Different Growth Phases in Bacillus subtilis
- Nanamiya Hideaki,Kawamura Fujio
- Bioscience, biotechnology, and biochemistry 74(3), 451-461, 2010-03-23
- … In developing a proteomic map of ribosomal proteins, we found that two types of L31 protein (RpmE and YtiA) were associated alternatively with the ribosome. … Under zinc-limiting conditions, RpmE, which contains one zinc atom per molecule, is replaced by YtiA, which does not contain zinc, in the 50S subunit of the ribosome. …
- NAID 10027552065
- Functional Study of the Residue C899 in the 900 Tetraloop of Escherichia coli Small Subunit Ribosomal RNA
- Ha Hye-Jeong,Song Woo-Seok,Kim Hong-Man [他],SON Ho-Sun,LEE Kangseok
- Bioscience, biotechnology, and biochemistry 73(11), 2544-2546, 2009-11-23
- … 16S rRNA, one implicated in a conformational switch in the dynamic movements of the ribosome, showed defects in subunit association and 30S initiation complex formation. …
- NAID 10027548302
Related Links
- The 30S ribosomal subunit has a crucial role in decoding mRNA by monitoring base pairing between the codon on mRNA and the anticodon on transfer RNA; the 50S subunit catalyses peptide-bond formation. Despite several 1. 2 ...
- The antibiotic concentration dependence of subunit formation was tested as well. Figure 3C and D show the inhibitory effects of increasing concentrations of each antibiotic on 30S ribosomal subunit assembly. With increasing drug ...
★リンクテーブル★
[★]
- 英
- 30S ribosomal subunit, 30S ribosome, 30S subunit
- 関
- 50Sリボソーム
抗菌薬の影響
[★]
- 関
- ribosomally、ribosome
[★]
リボソームサブユニット
- 関
- ribosome subunit