201Tl-塩化タリウム
English Journal
- [Dosimetry in scintimammography by (99m)Tc-MIBI, (99m)Tc-Tetrofosmin, (99m)Tc-(V)DMSA and 201TlCl compared with X-rays mammography].
- Lyra M, Vamvakas I.AbstractScintimammography is sometimes referred as a complementary diagnostic method to X-rays mammography and is the optimum examination for some patients to check suspected breast tumors. A dosimetric comparison of these diagnostic examinations is important. Estimation of the absorbed dose was achieved by calculations of internal dosimetry by Medical Internal Radiation Dose (MIRD) models and by calculations from the patients' scintigraphic images data using the MIRDOSE 3 program. The aim of this work was to compare the absorbed dose in scintimammography to that of X-rays mammography. Our results showed, that the breast absorbed dose by scintimammography examination using technetium-99m ((99m)Tc) complexes, 1.28mGy for (99m)Tc (V)-DMSA, 1.57mGy for (99m)Tc- MIBI and 1.92mGy for (99m)Tc-tetrofosmin, is considerably lower than the absorbed dose by scintimammography with thallium-201 chloride ((201)Tl-Cl) which reaches the 4.52mGy, or the absorbed dose by X-rays mammography. The absorbed mean glandular dose (MGD) for breast by X-rays mammography, taking 2 projections per breast, may reach 4.5mGy and is much higher for dense or large breasts. The European guidelines for quality assurance in breast cancer screening and diagnosis (2006, 4th edition) include a desirable level of less than 2.0mGy and an acceptable level of less than 2.5mGy for MGD for pressed breast thickness 4.5cm, per projection. In many radiology laboratories, specific care for every patient's radiation protection rules may reduce the MGD up to 1.4mGy per projection. Breast absorbed MGD in scintimammography by (99m)Tc-complexes mentioned above is reduced to more than half the above mentioned values for the examined breast and significantly lower than these levels for the not-examined breast. The radiation burden during scintimammography is also, many times lower than that of other radiology examinations including, lumbar spine radiography and pyelography. In conclusion, scintimammography is a low dose diagnostic method, and having also a high sensitivity, may be used as a complementary screening test in cases of dense breasts or breasts after surgery or breasts with prostheses, decreasing the necessity for breast biopsies.
- Hellenic journal of nuclear medicine.Hell J Nucl Med.2009 May-Aug;12(2):184-8.
- Scintimammography is sometimes referred as a complementary diagnostic method to X-rays mammography and is the optimum examination for some patients to check suspected breast tumors. A dosimetric comparison of these diagnostic examinations is important. Estimation of the absorbed dose was achieved by
- PMID 19675881
- Usefulness of 201TlCl/ 123I-BMIPP dual-myocardial SPECT for patients with non-ST segment elevation myocardial infarction.
- Fukushima Y, Toba M, Ishihara K, Mizumura S, Seino T, Tanaka K, Mizuno K, Kumita S.SourceDepartment of Clinical Radiology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. fuku@nms.ac.jp
- Annals of nuclear medicine.Ann Nucl Med.2008 Jun;22(5):363-9. Epub 2008 Jul 4.
- OBJECTIVE: Earlier studies suggested that elevated cardiac troponin T (cTnT) might be useful for detecting less severe types of myocardial injury (i.e., non-ST segment elevation myocardial infarction). The objective of this study is to elucidate the usefulness of (201)thallous chloride ((201)TlCl) a
- PMID 18600413
Japanese Journal
- Biological safety of nasal thallium-201 administration: A preclinical study for olfacto-scintigraphy
- WASHIYAMA Kohshin,SHIGA Hideaki,HIROTA Kyoko,TSUCHIDA Asuka,YAMAMOTO Junpei,YAGI Sayaka,YOSHIZAKI Tomokazu,FURUKAWA Mitsuru,AMANO Ryohei,MIWA Takaki
- Journal of radiation research 52(4), 450-455, 2011-07-16
- … 201Tl uptake was evaluated in normal mice (n = 5) in vivo by using a high-resolution gamma camera and radiography 15 min, 1, 2 and 9 d after administration of 201TlCl to the right side of the nasal cavity (10 μl 201TlCl per nostril, 74 MBq/ml). … Murine olfactory epithelial thickness (n = 5) was measured 9 d following nasal administration of 201TlCl. …
- NAID 10029122142
- ^<99m>Tc-MIBIシンチグラフィの有用性 : システマティックレビューおよびメタアナリシス
- 若杉 三奈子,風間 順一郎,成田 一衛
- 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 44(1), 65-72, 2011-01-28
- … シリーズ8論文,症例数合計96名,摘出副甲状腺数348腺が該当し,99mTc-MIBIの感度は72%[95%信頼区間=67〜77%]であった.他の術前画像診断の感度は,US 68%(163/238腺),CT 40%(44/111),MRI 65%(46/71),201TlCl/99mTcサブトラクション法40%(57/143)であった.【考察】諸外国の報告では99mTc-MIBIの感度が低いものもある.感度は疾患の重症度に影響を受けるため,各国の臨床現場で手術適応が異なっていることが影響 …
- NAID 10029405877
Related Links
- 201TlClの初期血中クリアランスの半減期は約5分、24時間以降における半減期は4日であった。腎臓においては、5分後まで増加する傾向をとり、10分以降は緩やかに減少する傾向を示した。心臓及び肺においては、本剤投与直後に ...
- タリウム腫瘍シンチグラムの説明201TlCl(タリウム)は腫瘍親和性のある放射性医薬品です。生理的に取り込むのは甲状腺、唾液腺、心筋などです。上記例では腫瘍に特異的に取り込んでいる様子がわかります。SPECTとはSingle Emisson ...
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- 関
- シンチグラフィー、シンチグラム
脳血流シンチグラム
脳槽シンチグラム
心筋シンチグラム
心筋壊死シンチグラム
心筋脂肪酸代謝シンチグラム
心筋交感神経シンチグラム
骨血流シンチグラム
肺換気シンチグラム
骨シンチグラム
骨髄シンチグラム
甲状腺シンチグラム
- 123I :(甲状腺摂取率)3時間値5-20%、24時間値15-35%
- 99mTcO4-:(甲状腺摂取率)30分値0.4-3.0%。唾液腺、唾液への生理的な取り込みが多いためバックグラウンドが高い。
- 131I :全身シンチグラムに使用。甲状腺全摘出後に行う。
- 123I-MIBG:甲状腺髄様癌
- 210Tl:分化型甲状腺癌
- 67Ga:甲状腺未分化癌、甲状腺悪性リンパ腫
副甲状腺シンチグラム
- 99mTc-MIBI:ヘキサキス(2-メトキシイソブチルイソニトリル)テクネチウム(99mTc):副甲状腺腫に集積
副腎髄質シンチグラム
副腎皮質シンチグラム
- 131I-アドステロール:クッシング症候群や原発性アルドステロンの確定診断に有用。たぶんステロール環をもっており副腎皮質に取り込まれる
腎シンチグラム
肝受容体シンチグラム
肝胆道シンチグラム
唾液腺シンチグラム
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ガリウムシンチグラム
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- 201TlCl
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- タリウム
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- 英
- thallium 201
- 同
- タリウム201
- 関
- 201Tl chloride、タリウム、201Tl-塩化タリウム
- 半減期:72.9 hr ≒ 3d
- 壊変様式:電子捕獲 EC
- 線種:γ線
- 20181Tl → 20180Hg + νe
- 放射線のエネルギー:Hg-X (71 keV), 167 keV