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1. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
2. 胎盤の発達および生理学 placental development and physiology
3. 骨粗鬆症の病因 pathogenesis of osteoporosis
4. 成人における肥満：病因および自然経過 obesity in adults etiology and natural history

English Journal

Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia.

Funghi L1, Damiani F1, Yen CF2, Lee CL3, Lombardi A1, Schatz F4, Lockwood CJ4, Marcolongo P1, Petraglia F1, Arcuri F5.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Dec 5;437:163-170. doi: 10.1016/j.mce.2016.08.023. Epub 2016 Aug 18.
Glucocorticoids are implicated in successful blastocyst implantation, whereas alterations in glucocorticoid levels are associated with various pregnancy disorders including preeclampsia. Tissue concentration of active glucocorticoids depends on the expression of 11β-hydroxysteroid dehydrogenase (11
PMID 27544778

11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.

Hardy RS1,2,3, Doig CL3, Hussain Z2,3, O'Leary M1, Morgan SA2,3, Pearson MJ1, Naylor A1, Jones SW1, Filer A1, Stewart PM4, Buckley CD1, Lavery GG2,3, Cooper MS5, Raza K1,6.
The Journal of pathology.J Pathol.2016 Dec;240(4):472-483. doi: 10.1002/path.4806. Epub 2016 Oct 18.
Muscle wasting is a common feature of inflammatory myopathies. Glucocorticoids (GCs), although effective at suppressing inflammation and inflammatory muscle loss, also cause myopathy with prolonged administration. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional GC-activating
PMID 27578244

Forebrain-specific transgene rescue of 11β-HSD1 associates with impaired spatial memory and reduced hippocampal BDNF mRNA levels in aged 11β-HSD1 deficient mice.

Caughey S1,2, Harris AP1,2, Seckl JR1,2, Holmes MC1,2, Yau JL1,2.
Journal of neuroendocrinology.J Neuroendocrinol.2016 Nov 17. doi: 10.1111/jne.12447. [Epub ahead of print]
Mice lacking the intracellular glucocorticoid-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) are protected from age-related spatial memory deficits. 11β-HSD1 is expressed predominantly in brain, liver and adipose tissue. Reduced glucocorticoid levels in brain in the absenc
PMID 27859809

Japanese Journal

メタボリックシンドロームと細胞内グルココルチコイド活性化酵素, 11beta-HSD1

日本内科学会雑誌 94(11), 2416-2422, 2005-11-10
NAID 10016927340

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