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1. 慢性炎症性脱髄性多発神経炎：病因、臨床的特徴、および診断 chronic inflammatory demyelinating polyneuropathy etiology clinical features and diagnosis
2. 免疫誘導性神経障害 immune mediated neuropathies
3. 多発性神経障害の概要 overview of polyneuropathy
4. 成人のギラン・バレー症候群：臨床的特徴と診断 guillain barre syndrome in adults clinical features and diagnosis
5. 上肢末梢神経症候群の概要 overview of upper extremity peripheral nerve syndromes

Related Pictures

慢性炎症性脱髄性多発神経炎／多巣性運動ニューロパチー診療ガイドライン検索システム慢性炎症性脱髄性多発根ニュ－ロパチ－，多巣性運動ニュ地域社会における共生の実現に向けて新たな障害保健福祉施策「医学のあゆみ」第5土曜特集第255巻5号免疫性神経疾患病態抹消神経の病気について｜CIDPスクエア免疫グロブリン療法を

★リンクテーブル★

リンク元	「multifocal demyelinating neuropathy」
拡張検索	「持続性伝導ブロックを伴う多巣性脱髄性ニューロパチー」
関連記事	「ニューロパチー」「脱髄」「脱髄性」「多巣性」

「multifocal demyelinating neuropathy」

　　[★] 多巣性脱髄性ニューロパチー

「持続性伝導ブロックを伴う多巣性脱髄性ニューロパチー」

　　[★]

英: multifocal demyelinating neuropathy with persistent conduction block
関: 多巣性運動神経障害、多巣性運動ニューロパチー multifocal motor neuropathy MMN

1982年にLewis, Sumnerが報告。ALSとの鑑別を要する病態。抗GM1-IgM抗体が上昇することがある。治療では大量ガンマグロブリン静注が奏効するものがある。

参考

1. Multifocal demyelinating neuropathy with persistent conduction block.

Lewis RA, Sumner AJ, Brown MJ, Asbury AK.AbstractWe describe five patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves. Diagnosis was established by electrophysiologic evidence of persistent multifocal conduction block. Sural nerve biopsy in three patients showed primarily demyelinating-remyelinating changes with varying degrees of fiber loss. Two patients had acute optic neuritis, indicating that the disorder was not always restricted to the peripheral nervous system. Two patients treated with corticosteroids improved, whereas three untreated patients had static deficits or steady progression of symptoms. Chronic multifocal demyelinating neuropathy with persistent conduction block seems to be a variant of chronic acquired demyelinating polyneuropathy and may be immunologically mediated.
Neurology.Neurology.1982 Sep;32(9):958-64.
We describe five patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves. Diagnosis was established by electrophysiologic evidence of persistent multifocal conduction block. Sural nerve biopsy in three patients s
PMID 7202168