基質アナログ : 約 93 件
基質類似体 : 約 77 件

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1. 成人女性の月経困難症：治療dysmenorrhea in adult women treatment [show details]
… these women treatment with a GnRH agonist analogue or antagonist. Agonist analogues include nafarelin (200 mcg intranasal spray… thin over time. The thin endometrium contains relatively small amounts of arachidonic acid, the substrate for most prostaglandin synthesis. As a result of these changes in the endometrium, estrogen-progestin …
2. 小児における、慢性腎臓病に伴う骨ミネラル代謝異常（CKD-MBD）pediatric chronic kidney disease mineral and bone disorder ckd mbd [show details]
… D with vitamin D analogues such as ergocalciferol or cholecalciferol in children with stages G2 to G4 disease as needed. Active vitamin D analogue (eg,… osteomalacia can still be seen in children who have inadequate intake of substrate (calcium and phosphate) or increased renal tubular losses.…
3. アシクロビル：概要acyclovir an overview [show details]
…which also requires phosphorylation for antiviral activity. However, foscarnet, a pyrophosphate analogue, is also a potent inhibitor of HSV DNA polymerase and does not require phosphorylation for its antiviral … resulting in either deficient thymidine kinase or an enzyme with altered substrate specificity .…
4. 血清および唾液中のコルチゾールの測定measurement of cortisol in serum and saliva [show details]
… monoclonal antibodies that are raised to a cortisol analogue that has been conjugated to a protein carrier.… and two-site antibody designs (one antibody is bound to a solid substrate,…
5. 中等症から重症の熱傷における代謝亢進反応hypermetabolic response to moderate to severe burn injury and management [show details]
… metabolic alterations can significantly change energy substrate metabolism.… The GLP-1 analogue tested in this trial appears to be safe and reliably modulated glucose in these patients.…

Japanese Journal

耐熱性カルボニル還元酵素の結晶構造解析と基質認識機構の解明

米田一成,福田雄大,荒木朋洋
東海大学紀要. 農学部 = Proceedings of School of Agriculture, Tokai University 36, 1-6, 2017
… 本研究では超好熱菌であるAeropyrum pernix K1由来の耐熱性CRのNADPH-酒石酸(基質アナログ)との3者複合体の結晶構造解析を行うとともに，CRの酵素反応産物である(S)-4-クロロ-3-ヒドロキシ酪酸エチル[(S)-CHBE]の構造を活性中心にモデリングした。 …
NAID 40021168037

トリテルペン環化酵素：基質のメチル基が環化フォールデングや多環化反応へ及ぼす影響～ラノステロール及びβ-アミリン合成酵素を中心として～

星野力,千葉彬文,阿部奈緒美,花岡正樹,山口雄生,宮原悠里,高橋一成
天然有機化合物討論会講演要旨集 55(0), Oral30, 2013
… 6)この事例が示すように、基質アナログによる研究は反応機構解明に向けて重要なツールとなっている。 … ２.ラノステロール合成酵素化学合成した基質アナログ7, 8を豚肝臓ミクロソーム画分から酵素を部分精製し反応を行った。 …
NAID 130006470643