central lymphoid organでおこる自己寛容

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1. がんサバイバーや小児期に細胞障害性抗癌剤による治療を受けた患者の内分泌疾患endocrinopathies in cancer survivors and others exposed to cytotoxic therapies during childhood [show details]
… endocrinologist for dynamic testing of adrenal function. Tests for appropriate central regulation of adrenal function include the insulin tolerance test, glucagon stimulation test, ACTH stimulation and metyrapone tests …
2. 中心静脈カテーテルと成人患者に適したカテーテルの選択基準central venous access devices and approach to selection in adults [show details]
…appropriate than central venous access. When central venous access is indicated, we use the following approach : For emergency access: Large-bore peripheral access, nontunneled single-lumen central access (eg …
3. 中枢型睡眠無呼吸症候群を有する成人患者における陽圧呼吸調整法のモード選択mode selection for positive airway pressure titration in adult patients with central sleep apnea syndromes [show details]
…failure. In this population, central apneas tend to be a minor component of the sleep-disordered breathing. In patients with central sleep apnea (CSA) whose central apneas are largely due to hypoventilation …
4. 原発性免疫不全症患者における自己免疫autoimmunity in patients with primary immunodeficiency [show details]
…organs and susceptibility to candidiasis Defects in B cell function and tolerance – In B cell development, central tolerance is achieved by receptor-editing in the bone marrow, which removes naive B …
5. 自己免疫の概要overview of autoimmunity [show details]
…the natural killer (NK) receptor (called NK-T cells) can also regulate autoimmune disease . Central tolerance is induced in B cells as well as T cells but, in general, is less efficient. Natural autoantibodies …

Japanese Journal

Nr4aファミリー転写因子によるTreg制御 (第5土曜特集制御性T細胞研究の現在) -- (基礎)

関谷高史
医学のあゆみ 268(13), 1069-1074, 2019-03-30
NAID 40021850666

専門スタディー3-1　T細胞　T細胞免疫寛容と自己免疫疾患

松本満
日本臨床免疫学会会誌 39(4), 323-323, 2016
… <p> 自己免疫疾患は胸腺における中枢性トレランス（central tolerance），あるいは末梢性トレランス（peripheral tolerance）の機能不全によってT細胞の免疫寛容が失われる結果，発症すると考えられる．この内，胸腺における中枢性トレランスの破綻モデルとして，胸腺髄質上皮細胞に発現するAIRE遺伝子の欠損症はT細胞免疫寛容の確立における胸腺髄質上皮細胞の役割，ならびにその機能喪失による …
NAID 130005407743