WordNet

an impairment of health or a condition of abnormal functioning
being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate

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1. 骨髄増殖性腫瘍の概要 overview of the myeloproliferative neoplasms
2. 原発性骨髄線維症の臨床症状および診断 clinical manifestations and diagnosis of primary myelofibrosis
3. 真性多血症の予後および治療 prognosis and treatment of polycythemia vera
4. 本態性血小板血症の診断および臨床症状 diagnosis and clinical manifestations of essential thrombocythemia
5. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia

Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia.

Mancini M, Veljkovic N, Leo E, Aluigi M, Borsi E, Galloni C, Iacobucci I, Barbieri E, Santucci MA.SourceDipartimento di Ematologia e Scienze Oncologiche "Lorenzo e Ariosto Seràgnoli," University of Bologna-Medical School, Bologna, Italy. mancini_manu@yahoo.com.
Journal of cellular biochemistry.J Cell Biochem.2012 Aug;113(8):2765-74. doi: 10.1002/jcb.24154.
The loss-of-function of ten-eleven-translocation (TET) 2, a Fe(2+) -oxoglutarate-dependent dioxygenase catalyzing 5 methyl cytosine (5mC) conversion into 5-hydroxymethylcytosine (5hmC), contributes to the hematopoietic transformation in vivo. The aim of our study was to elucidate its role in the phe
PMID 22467095

Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice.

Döring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, Zernecke A.SourceRudolf-Virchow-Center/DFG-Research Center for Experimental Biomedicine, University of Würzburg, Joseph-Schneider Str. 2, 97080 Würzburg, Germany. alma.zernecke@virchow.uni-wuerzburg.de or oliver.soehnlein@med.uni-muenchen.de.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2012 Jul;32(7):1613-23. Epub 2012 May 3.
OBJECTIVE: Inflammatory leukocyte accumulation drives atherosclerosis. Although monocytes/macrophages and polymorphonuclear neutrophilic leukocytes (PMN) contribute to lesion formation, sequelae of myeloproliferative disease remain to be elucidated.METHODS AND RESULTS: We used mice deficient in inte
PMID 22556330

竹中克斗
臨床血液 60(6), 610-618, 2019
… 骨髄増殖性腫瘍（myeloproliferative neoplasms, MPN）は，真性赤血球増加症，本態性血小板増多症，原発性骨髄線維症が代表的疾患であるが，その病態の中心は，JAK/STATシグナルの恒常的活性化である。 …
NAID 130007675225

山口博樹
臨床血液 56(8), 939-948, 2015
慢性骨髄増殖性腫瘍(cMPN)である真性赤血球増加症の約90%, 本態性血小板血症や原発性骨髄線維症(PMF)の約半数にJAK2V617F変異が発見された。その後JAK2 exon 12 deletion, MPLW515L/K, CALR遺伝子変 …
NAID 130005096295

武藤秀治,坂田（柳元）麻実子,千葉滋
臨床血液 56(6), 651-656, 2015
TET (Ten Eleven Translocation)ファミリータンパク質はメチルシトシンをヒドロキシメチルシトシンに変換する酵素であり，DNAの脱メチル化に重要な役割を果たしている。中でもTET2遺伝子異常は，骨髄異形成症候群，骨髄増殖性腫瘍，慢性骨髄単球性白血病，急性骨髄性白血病などの骨髄球系造血器腫瘍のみならず，血管免疫芽球性T細胞性リンパ腫，分類 …
NAID 130005093097