tissue factor pathway inhibitor

組織因子経路インヒビター TFPI

同

TFPI

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
12. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
13. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
14. a soft thin (usually translucent) paper (同)tissue_paper
15. part of an organism consisting of an aggregate of cells having a similar structure and function
16. a substance that retards or stops an activity

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
4. 〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper
5. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/07 01:36:25」(JST)

wiki en

[Wiki en表示]

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
PDB rendering based on 1adz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ADZ, 1IRH, 1TFX, 4DTG
Identifiers
Symbols	TFPI ; EPI; LACI; TFI; TFPI1
External IDs	OMIM: 152310 MGI: 1095418 HomoloGene: 4579 GeneCards: TFPI Gene
Gene ontology Molecular function • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • extracellular region • extracellular space • endoplasmic reticulum • plasma membrane • organelle membrane • anchored to membrane Biological process • blood coagulation • blood coagulation, extrinsic pathway • negative regulation of endopeptidase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7035	21788
Ensembl	ENSG00000003436	ENSMUSG00000027082
UniProt	P10646	O54819
RefSeq (mRNA)	NM_001032281	NM_001177319
RefSeq (protein)	NP_001027452	NP_001170790
Location (UCSC)	Chr 2: 188.33 – 188.43 Mb	Chr 2: 84.43 – 84.48 Mb
PubMed search	[1]	[2]

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

Genetics

The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

Protein structure

TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

TFPI consists of a highly negatively charged amino-terminus, three tandemly linked Kunitz domains, and a highly positively charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.

Interactions

Tissue factor pathway inhibitor has been shown to interact with Factor X.

See also

• Hemostasis

References

External links

• Online 'Mendelian Inheritance in Man' (OMIM) 152310 (TFPI1), Online 'Mendelian Inheritance in Man' (OMIM) 600033 (TFPI2)

Further reading

• Broze GJ, Girard TJ, Novotny WF (1991). "Regulation of coagulation by a multivalent Kunitz-type inhibitor.". Biochemistry 29 (33): 7539–46. doi:10.1021/bi00485a001. PMID 2271516. 
• McVey JH (2000). "Tissue factor pathway.". Baillieres Best Pract. Res. Clin. Haematol. 12 (3): 361–72. PMID 10856975. 
• Bajaj MS, Birktoft JJ, Steer SA, Bajaj SP (2002). "Structure and biology of tissue factor pathway inhibitor.". Thromb. Haemost. 86 (4): 959–72. PMID 11686353. 
• Witt I (2002). "[Tissue factor pathway inhibitor: biochemistry, molecular biology, physiology and physiopathology]". Hamostaseologie 22 (2): 30–5. doi:10.1267/Hamo02020071. PMID 12193974. 
• Lwaleed BA, Bass PS (2006). "Tissue factor pathway inhibitor: structure, biology and involvement in disease.". J. Pathol. 208 (3): 327–39. doi:10.1002/path.1871. PMID 16261634. 
• Van der Logt CP, Kluck PM, Wiegant J, et al. (1992). "Refined regional assignment of the human tissue factor pathway inhibitor (TFPI) gene to chromosome band 2q32 by non-isotopic in situ hybridization.". Hum. Genet. 89 (5): 577–8. doi:10.1007/bf00219189. PMID 1353057. 
• Higuchi DA, Wun TC, Likert KM, Broze GJ (1992). "The effect of leukocyte elastase on tissue factor pathway inhibitor.". Blood 79 (7): 1712–9. PMID 1558967. 
• van der Logt CP, Reitsma PH, Bertina RM (1991). "Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation.". Biochemistry 30 (6): 1571–7. doi:10.1021/bi00220a018. PMID 1993173. 
• Girard TJ, Eddy R, Wesselschmidt RL, et al. (1991). "Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2.". J. Biol. Chem. 266 (8): 5036–41. PMID 2002045. 
• Wun TC, Kretzmer KK, Girard TJ, et al. (1988). "Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.". J. Biol. Chem. 263 (13): 6001–4. PMID 2452157. 
• Novotny WF, Girard TJ, Miletich JP, Broze GJ (1989). "Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma.". J. Biol. Chem. 264 (31): 18832–7. PMID 2553722. 
• Girard TJ, Warren LA, Novotny WF, et al. (1989). "Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.". Thromb. Res. 55 (1): 37–50. doi:10.1016/0049-3848(89)90454-4. PMID 2781520. 
• Girard TJ, Warren LA, Novotny WF, et al. (1989). "Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor.". Nature 338 (6215): 518–20. doi:10.1038/338518a0. PMID 2927510. 
• Broze GJ, Miletich JP (1987). "Characterization of the inhibition of tissue factor in serum.". Blood 69 (1): 150–5. PMID 3024756. 
• Broze GJ, Warren LA, Novotny WF, et al. (1988). "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action.". Blood 71 (2): 335–43. PMID 3422166. 
• Rao LV, Rapaport SI (1987). "Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation.". Blood 69 (2): 645–51. PMID 3492226. 
• Stubbs MT, Huber R, Bode W (1996). "Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.". FEBS Lett. 375 (1-2): 103–7. doi:10.1016/0014-5793(95)01190-P. PMID 7498454. 
• Warshawsky I, Bu G, Mast A, et al. (1995). "The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo.". J. Clin. Invest. 95 (4): 1773–81. doi:10.1172/JCI117855. PMC 295702. PMID 7706485. 
• Broze GJ, Lange GW, Duffin KL, MacPhail L (1995). "Heterogeneity of plasma tissue factor pathway inhibitor.". Blood Coagul. Fibrinolysis 5 (4): 551–9. PMID 7841311. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 止血の概要 overview of hemostasis
• 2. 敗血症に対する治験剤および無効剤 investigational and ineffective therapies for sepsis
• 3. Vascular endothelial function and fundamental mechanisms of fibrinolysis (thrombolysis)
• 4. 糸球体半月体形成の機序 mechanisms of glomerular crescent formation
• 5. Treatment of community-acquired pneumonia in adults who require hospitalization

English Journal

• Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin d deficiency?

• Topaloglu O1, Arslan MS2, Karakose M2, Ucan B2, Ginis Z3, Cakir E2, Akkaymak ET2, Sahin M4, Ozbek M2, Cakal E2, Delibasi T2.
• Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.Clin Appl Thromb Hemost.2015 Jul;21(5):428-33. doi: 10.1177/1076029613509477. Epub 2013 Nov 6.
• OBJECTIVE: The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).METHODS: Patients who had 25-hydroxyvitamin D3 (25(OH)D3) levels measured were included. Coagulation and hemostatic parameters were evaluated.
• PMID 24203351

• Thrombin Down-Regulates Tissue Factor Pathway Inhibitor Expression in a PI3K/Nuclear Factor-κB-Dependent Manner in Human Pleural Mesothelial Cells.

• Jeffers A1, Owens S, Koenig K, Quaid B, Pendurthi UR, Rao VM, Idell S, Tucker TA.
• American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2015 Jun;52(6):674-82. doi: 10.1165/rcmb.2014-0084OC.
• Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade, and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity by regulating its expression or by modifying the protein. It is not
• PMID 25303460

• Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass.

• Percy CL1, Hartmann R, Jones RM, Balachandran S, Mehta D, Dockal M, Scheiflinger F, O'Donnell VB, Hall JE, Collins PW.
• Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2015 Jun;26(4):357-67. doi: 10.1097/MBC.0000000000000243.
• Recently, lower thrombin generation has been associated with excess bleeding post-cardiopulmonary bypass (CPB). Therefore, treatment to correct thrombin generation is a potentially important aspect of management of bleeding in this group of patients. The objective of the present study was to investi
• PMID 25928274

Japanese Journal

• Regulation of hepcidin expression by inflammation-induced activin B

• Scientific Reports 6, 2016-12-06
• NAID 120005997849

• AICAR Attenuates TNFα-Induced Inappropriate Secretion of Monocyte Chemoattractant Protein-1 and Adiponectin in 3T3-L1 Adipocytes

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 23(12), 1345-1354, 2016
• NAID 130005171054

• Carvacrol Inhibits Osteoclastogenesis and Negatively Regulates the Survival of Mature Osteoclasts

• Biological and Pharmaceutical Bulletin 39(7), 1150-1158, 2016
• NAID 130005160781

Related Links

• TISSUE FACTOR PATHWAY INHIBITOR: STRUCTURE ...

2. INTRODUCTION As early as 1922, Loeb suggested that serum contained a moiety that inhibits the procoagulant activity of tissue extracts (1, 2). Later, Thomas (3) and Schneider (4) independently demonstrated the in vivo correlate ...

• tissue factor pathway inhibitor - definition of tissue factor ...

tissue factor pathway inhibitor (extrinsic factor) lipoprotein-associated coagulation inhibitor Hematology A coagulation factor X-dependent inhibitor of the factor VIIa/tissue factor complex; it is a plasma lipoprotein that regulates ...

Related Pictures

---

★リンクテーブル★

リンク元	「組織因子経路インヒビター」「TFPI」
関連記事	「inhibit」「inhibitor」「fact」「factor」「pathway」

「組織因子経路インヒビター」

　　[★]

英

tissue factor pathway inhibitor, TFPI

関

血液凝固因子

生理作用

• 外因系凝固反応の開始を阻止：F III, F VIIa, F Xaを不活性化する

• 組織因子、FVIIa　→　K1領域　結合

FXa　→　K2領域

「TFPI」

　　[★] 組織因子経路インヒビター tissue factor pathway inhibitor

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「pathway」

　　[★]

• 経路、パスウェイ

関

route