refractory

出典: meddic

  • adj.
  • 手に負えない、御しがたい
  • (病気などが)難治性の、抗療性の。(刺激に)不応性の、無反応性の。抵抗性がある、免疫性の(to)


intractableinveteraterecalcitrancerecalcitrantrefractorinessresistanceresistantresistive

WordNet   license wordnet

「temporarily unresponsive or not fully responsive to nervous or sexual stimuli; "the refractory period of a muscle fiber"」

WordNet   license wordnet

「not responding to treatment; "a stubborn infection"; "a refractory case of acne"; "stubborn rust stains"」
stubborn

PrepTutorEJDIC   license prepejdic

「(人などが)手に負えない,強情な / (病気が)治りにくい,がんこな / (金属などが)溶けにくい,耐火性の」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/27 15:48:41」(JST)

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英文文献

  • Acrodermatitis continua of Hallopeau (ACH): two cases successfully treated with adalimumab.
  • Di Costanzo L1, Napolitano M, Patruno C, Cantelli M, Balato N.Author information 1Department of Clinical Medicine and Surgery, University of Naples Federico II , Naples ,  Italy.AbstractAcrodermatitis continua of Hallopeau (ACH), also known as dermatitis repens or acrodermatitis perstans, is a rare acropustular eruption, characterized by sterile pustules, paronychia and atrophic skin changes, onychodystrophy and osteolysis of the distal phalanges of the fingers and toes. While some consider ACH a distinct entity, many believe it to be a variant of pustular psoriasis, especially as cases of ACH progressing to generalized pustular psoriasis. The treatment options used are various; however, its typical cyclic recurrences, which induce important physical and psychological morbidity, may render this pathology difficult to treat. Hence, it was considered important to review the evolution of treatment options available thus far including use of biologics. Hereby, we report two patients with ACH who were successfully treated with adalimumab. By analogy to the efficacy of TNF-α antagonists in the treatment of generalized pustular psoriasis, the two patients we report illustrate the long-term efficacy and safety of adalimumab in the treatment of  Hallopeau's acrodermatitis refractory to therapies.
  • The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):489-94. doi: 10.3109/09546634.2013.848259. Epub 2013 Nov 12.
  • Acrodermatitis continua of Hallopeau (ACH), also known as dermatitis repens or acrodermatitis perstans, is a rare acropustular eruption, characterized by sterile pustules, paronychia and atrophic skin changes, onychodystrophy and osteolysis of the distal phalanges of the fingers and toes. While some
  • PMID 24215490
  • Efficacy of leukotriene receptor antagonist with anti-H1 receptor antagonist plus anti-H2 receptor antagonist for treatment of refractory chronic idiopathic urticaria.
  • Wan KS1, Chang YS.Author information 1Department of Pediatrics, Taipei City Hospital , Renai Branch , Taiwan and.AbstractBACKGROUND: The efficacy of the combination of leukotriene receptor antagonist (LRA) and H1 antihistamine was similar to the synergistic regimen of H1 and H2 antihistamine for treatment of chronic idiopathic urticaria (CIU). However, the effective rates of these two regimens were only 53.3% and 63.3%, respectively.
  • The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):459-61. doi: 10.3109/09546634.2013.849791. Epub 2013 Nov 5.
  • BACKGROUND: The efficacy of the combination of leukotriene receptor antagonist (LRA) and H1 antihistamine was similar to the synergistic regimen of H1 and H2 antihistamine for treatment of chronic idiopathic urticaria (CIU). However, the effective rates of these two regimens were only 53.3% and 63.3
  • PMID 24192062
  • Comparison of intradermal injection with iontophoresis of abobotulinum toxin A for the treatment of primary axillary hyperhidrosis: a randomized, controlled trial.
  • Montaser-Kouhsari L1, Zartab H, Fanian F, Noorian N, Sadr B, Nassiri-Kashani M, Firooz A.Author information 1Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences , Tehran , Iran.AbstractBACKGROUND: Botulinum neurotoxin type A (BTX-A) injection is the treatment of choice for idiopathic axillary hyperhidrosis (IAH) refractory to conventional treatments.
  • The Journal of dermatological treatment.J Dermatolog Treat.2014 Aug;25(4):337-41. doi: 10.3109/09546634.2012.739679. Epub 2013 Jan 20.
  • BACKGROUND: Botulinum neurotoxin type A (BTX-A) injection is the treatment of choice for idiopathic axillary hyperhidrosis (IAH) refractory to conventional treatments.OBJECTIVE: This study compared the efficacy of BTX-A injection and iontophoresis for treatment of IAH in a randomized controlled tria
  • PMID 23106157
  • Beyond blow-up in excitatory integrate and fire neuronal networks: Refractory period and spontaneous activity.
  • Cáceres MJ1, Perthame B2.Author information 1Departamento de Matemática Aplicada, Universidad de Granada, E-18071 Granada, Spain. Electronic address: caceresg@ugr.es.2UPMC Univ. Paris 06, CNRS UMR 7598, Laboratoire Jacques-Louis Lions, F75005 Paris, France; INRIA Rocquencourt EPI BANG, France. Electronic address: benoit.perthame@upmc.fr.AbstractThe Network Noisy Leaky Integrate and Fire equation is among the simplest model allowing for a self-consistent description of neural networks and gives a rule to determine the probability to find a neuron at the potential v. However, its mathematical structure is still poorly understood and, concerning its solutions, very few results are available. In the midst of them, a recent result shows blow-up in finite time for fully excitatory networks. The intuitive explanation is that each firing neuron induces a discharge of the others; thus increases the activity and consequently the discharge rate of the full network. In order to better understand the details of the phenomena and show that the equation is more complex and fruitful than expected, we analyze further the model. We extend the finite time blow-up result to the case when neurons, after firing, enter a refractory state for a given period of time. We also show that spontaneous activity may occur when, additionally, randomness is included on the firing potential VF in regimes where blow-up occurs for a fixed value of VF.
  • Journal of theoretical biology.J Theor Biol.2014 Jun 7;350:81-9. doi: 10.1016/j.jtbi.2014.02.005. Epub 2014 Feb 15.
  • The Network Noisy Leaky Integrate and Fire equation is among the simplest model allowing for a self-consistent description of neural networks and gives a rule to determine the probability to find a neuron at the potential v. However, its mathematical structure is still poorly understood and, concern
  • PMID 24533963

和文文献

  • 新規抗体/薬物複合体によるリンパ系腫瘍の治療 : イノツズマブ・オゾガマイシンとブレンツキシマブ・ベドチン (特集 新規ターゲットおよび医薬品による血液がん治療の新たな展開)
  • 網膜中心静脈閉塞症の治療抵抗性黄斑浮腫に対する網膜血管内治療 (特集 最先端の硝子体手術)
  • 門之園 一明
  • あたらしい眼科 32(2), 197-202, 2015-02
  • NAID 40020373522
  • 内境界膜自家移植による難治性黄斑円孔の治療 (特集 最先端の硝子体手術)
  • 森實 祐基,白神 史雄
  • あたらしい眼科 32(2), 189-195, 2015-02
  • NAID 40020373511
  • 中村賞受賞者 難治性網膜硝子体疾患における線維性増殖組織形成に対するSex hormoneの作用
  • 木村 和博
  • 山口医学 = Yamaguchi medical journal 64(1), 11-16, 2015-02
  • NAID 40020361446

関連リンク

refractoryとは。意味や和訳。[形]((形式))1 御しがたい, 手に負えない, 強情な, 頑固なa refractory schoolboy言うことをきかない男生徒.2 〈病気が〉治りにくいa refractory disease難病.3 〈生物が〉(病菌に)抵抗力がある;(…に ...
refractoryの意味は?goo辞書は無料で使える日本最大級の辞書サービスです。国語辞典、英和辞典、和英辞典、類語辞典、中国語辞典、百科事典などを提供しています。 ... gooのお知らせ gooヘルスケア「おもいやり食堂」 7月のおもいや ...
Shanghai GongYe International supplies multiple types of refractories, ceramic fiber insulation materials, and graphite sheet and foils for various high temperature industries. ... Effective & Economic Solutions For Industrial Heat: We ...

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★リンクテーブル★
リンク元intractable」「recalcitrant」「resistant」「resistive」「refractoriness
拡張検索vitamin B12-refractory megaloblastic anemia
関連記事refractor

intractable」

  [★]

  • adj.
  • 御しにくい、手に負えない、強情な。処置\加工しにくい。(病気などが)治りにくい、難治の/難治性の。
plasmapheresis has been utilized rarely in patients with severe intractable pruritus.
Ongoing diuretic resistance with intractable edema and hypertension in advanced CKD may serve as an indication to initiate dialysis.(HIM.1764)
arduousdifficultdifficultydistresshardinveteratelaboredrecalcitrantrefractorytrouble

WordNet   license wordnet

「not tractable; difficult to manage or mold; "an intractable disposition"; "intractable pain"; "the most intractable issue of our era"; "intractable metal"」

PrepTutorEJDIC   license prepejdic

「(人・人の性質が)手に負えない,強情な / (物事が)処理しにくい,取り扱いにくい」

recalcitrant」

  [★]

  • adj.
  • 不応性の、強情な、困難な
arduousdifficultdifficultydistresshardintractablelaboredrecalcitrancerefractorinessrefractorytrouble

WordNet   license wordnet

「marked by stubborn resistance to authority; "the University suspended the most recalcitrant demonstrators"」

PrepTutorEJDIC   license prepejdic

「かたくなで手に負えない,言うことを聞かない / 扱いにくい人」

resistant」

  [★]

  • adj.
  • 抵抗性の、耐性の、抵抗する
recalcitrancerefractoryresistresistanceresistivestandtolerancetolerantwithstand

WordNet   license wordnet

「impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion"」

PrepTutorEJDIC   license prepejdic

「抵抗力のある;(…に)抵抗する《+『to』+『名』》」

resistive」

  [★]

  • 抵抗性の
recalcitrancerefractoryresistanceresistant

WordNet   license wordnet

「exhibiting or relating to electrical resistance; "resistive load"」

PrepTutorEJDIC   license prepejdic

「抵抗する,抵抗力のある / 抵抗性の」


refractoriness」

  [★]

recalcitrancerecalcitrantrefractory

WordNet   license wordnet

「the trait of being unmanageable」
unmanageableness, recalcitrance, recalcitrancy


vitamin B12-refractory megaloblastic anemia」

  [★] ビタミンB12不応性巨赤芽球性貧血

refractor」

  [★]

PrepTutorEJDIC   license prepejdic

「屈折媒体(レンズ) / =refracting telescope」




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