WordNet

temporarily unresponsive or not fully responsive to nervous or sexual stimuli; "the refractory period of a muscle fiber"
not responding to treatment; "a stubborn infection"; "a refractory case of acne"; "stubborn rust stains" (同)stubborn

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Removal of oxalic acid, oxamic acid and aniline by a combined photolysis and ozonation process.

Orge CA1, Faria JL, Pereira MF.
Environmental technology.Environ Technol.2015 May;36(9):1075-83. doi: 10.1080/09593330.2014.974682. Epub 2014 Nov 13.
Aniline (ANL), an aromatic amine, oxalic acid (OXA) and oxamic acid (OMA), short-chain carboxylic acids, were chosen as model organic pollutants for testing the combined effect of neat photolysis and ozonation in the treatment of aqueous effluents. In order to better understand the results, single o
PMID 25295389

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

Song EK1, Tai W, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Pitts TM, Wang G, Blatchford P, Yahn R, Kaplan J, Tan AC, Atreya CE, Eckhardt G, Kelley RK, Venook A, Kwak EL, Ryan D, Arcaroli JJ.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Apr 15;136(8):1967-75. doi: 10.1002/ijc.29225. Epub 2014 Sep 29.
Antiangiogenic therapy is commonly used for the treatment of colorectal cancer (CRC). Although patients derive some clinical benefit, treatment resistance inevitably occurs. The MET signaling pathway has been proposed to be a major contributor of resistance to antiangiogenic therapy. MET is upregula
PMID 25242168

Interobserver variance in myelodysplastic syndromes with less than 5 % bone marrow blasts: unilineage vs. multilineage dysplasia and reproducibility of the threshold of 2 % blasts.

Font P1, Loscertales J, Soto C, Ricard P, Novas CM, Martín-Clavero E, López-Rubio M, Garcia-Alonso L, Callejas M, Bermejo A, Benavente C, Ballesteros M, Cedena T, Calbacho M, Urbina R, Villarrubia J, Gil S, Bellón JM, Diez-Martin JL, Villegas A.
Annals of hematology.Ann Hematol.2015 Apr;94(4):565-73. doi: 10.1007/s00277-014-2252-4. Epub 2014 Nov 13.
Previous studies have shown the reproducibility of the 2008 World Health Organization (WHO) classification in myelodysplastic syndromes (MDS), especially when multilineage dysplasia or excess of blasts are present. However, there are few data regarding the reproducibility of MDS with unilineage dysp
PMID 25387664