WordNet

complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
(psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior
make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)
(…に)…'を'『適応させる』,適合させる《+『名』+『to』+『名』(do『ing』)》 / (…向きに)〈小説・戯曲など〉'を'『脚色する』,翻案する,書きかえる《+『名』+『for』+『名』》 / (環境などに)適応する,順応する《+『to』+『名』》
蛋白(たんばく)質

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1. 先天性好中球減少症 congenital neutropenia
2. 症候群をきたす免疫不全症 syndromic immunodeficiencies
3. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
4. マントル細胞リンパ腫の病理学 pathobiology of mantle cell lymphoma
5. 組織球性肉腫 histiocytic sarcoma

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly.

Hardies K, May P, Djémié T, Tarta-Arsene O, Deconinck T, Craiu D; AR working group of the EuroEPINOMICS RES Consortium, Helbig I, Suls A, Balling R, Weckhuysen S, De Jonghe P, Hirst J.
Human molecular genetics.Hum Mol Genet.2014 Dec 30. pii: ddu740. [Epub ahead of print]
We report two siblings with infantile onset seizures, severe developmental delay and spastic paraplegia, in whom whole-genome sequencing revealed compound heterozygous mutations in the AP4S1 gene, encoding the σ subunit of the adaptor protein complex 4 (AP-4). The effect of the predicted loss-of-fu
PMID 25552650

Robinson M, Sedwick C.
The Journal of cell biology.J Cell Biol.2014 Sep 15;206(6):692-3. doi: 10.1083/jcb.2066pi.
PMID 25225335

Autosomal recessive spastic tetraplegia caused by AP4M1 and AP4B1 gene mutation: expansion of the facial and neuroimaging features.

Tüysüz B1, Bilguvar K, Koçer N, Yalçınkaya C, Çağlayan O, Gül E, Sahin S, Çomu S, Günel M.
American journal of medical genetics. Part A.Am J Med Genet A.2014 Jul;164A(7):1677-85. doi: 10.1002/ajmg.a.36514. Epub 2014 Apr 3.
Adaptor protein complex-4 (AP4) is a component of intracellular transportation of proteins, which is thought to have a unique role in neurons. Recently, mutations affecting all four subunits of AP4 (AP4M1, AP4E1, AP4S1, and AP4B1) have been found to cause similar autosomal recessive phenotype consis
PMID 24700674

Non-Markovian properties and multiscale hidden Markovian network buried in single molecule time series

Sultana Tahmina,Takagi Hiroaki,Morimatsu Miki,Teramoto Hiroshi,Li Chun-Biu,Sako Yasushi,Komatsuzaki Tamiki
Journal of chemical physics 139(24), 245101-1-245101-12, 2013-12-28
… To demonstrate the potential of our scheme, we investigated single-molecule time series of dissociation and association kinetics between epidermal growth factor receptor (EGFR) on the plasma membrane and its adaptor protein Ash/Grb2 (Grb2) in an in vitro reconstituted system. …
NAID 120005385318

Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3

Suzuki Tadaki,Orba Yasuko,Makino Yoshinori,Okada Yuki,Sunden Yuji,Hasegawa Hideki,Hall William W.,Sawa Hirofumi
Proceedings of the National Academy of Sciences of the United States of America 110(46), 18668-18673, 2013-11-12
… Here we demonstrate that the JCV agnoprotein specifically interacts with adaptor protein complex 3 through its delta subunit. …
NAID 120005429604