- 関
- eIF-4E、eIF4E、eukaryotic translation initiation factor 4E
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the act of starting something for the first time; introducing something new; "she looked forward to her initiation as an adult"; "the foundation of a new scientific society" (同)founding, foundation, institution, origination, creation, innovation, introduction, instauration
- a formal entry into an organization or position or office; "his initiation into the club"; "he was ordered to report for induction into the army"; "he gave a speech as part of his installation into the hall of fame" (同)induction, installation
- having cells with `good or membrane-bound nuclei (同)eucaryotic
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- 〈U〉開始;創業 / 〈U〉入会,入門;〈C〉入会(入門)式 / 〈U〉手ほどき,伝授
UpToDate Contents
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- 1. 孤発性リンパ脈管筋腫症：疫学と発症機序sporadic lymphangioleiomyomatosis epidemiology and pathogenesis [show details]
… of the eukaryotic translation initiation factor (eIF4F) complex and phosphorylating downstream targets including eIF4F binding proteins (4E-BPs) and ribosomal protein S6 kinases . Other factors that have …
- 2. 原発性早期卵巣障害（早期卵巣機能不全）の病因と原因pathogenesis and causes of spontaneous primary ovarian insufficiency premature ovarian failure [show details]
…familial cases of POI. A rare heterozygous nonsense mutation in the eukaryotic translation initiation factor 4E nuclear import factor 1 (eIF4ENIF1) has been identified in a family with nine women in three …
- 3. 第XI（11）因子欠乏症factor xi eleven deficiency [show details]
… system : Thrombin generation – Factor XI does not participate in the initiation of clotting; the initial burst of thrombin comes from circulating factor VIIa and tissue factor (TF, which is usually exposed …
- 4. 小児や青年への喫煙開始の予防策prevention of smoking initiation in children and adolescents [show details]
…children to avoid smoking initiation. The discussion should specifically include information about e-cigarettes and similar devices. Recognizing risk factors for smoking initiation in individual patients …
- 5. 静脈血栓塞栓症：抗凝固療法の開始（開始後10日間） venous thromboembolism initiation of anticoagulation first 10 days [show details]
… whether or not thrombolysis is anticipated: Factor Xa and direct thrombin inhibitors – When factor Xa and direct thrombin inhibitors are chosen,… four to five days) plus initiation of warfarin on day 1 is as effective as longer courses of heparin (10 to 14 days) with the delayed initiation of warfarin (eg,…
English Journal
- Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750 - an antisense oligonucleotide against eIF4E - in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
- Duffy AG1, Makarova-Rusher OV1, Ulahannan SV1, Rahma OE1, Fioravanti S1, Walker M1, Abdullah S2, Raffeld M2, Anderson V3, Abi-Jaoudeh N3, Levy E3, Wood BJ3, Lee S4, Tomita Y4, Trepel JB4, Steinberg SM5, Revenko AS6, MacLeod AR6, Peer CJ7, Figg WD7, Greten TF1.
- International journal of cancer.Int J Cancer.2016 May 19. doi: 10.1002/ijc.30199. [Epub ahead of print]
- The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal carcinogenesis (CRC). ISIS 183750 is a second-generation antisense oligonucleotide (ASO) designed to inhibit the production of the eIF4E protein.
- PMID 27194579
- Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
- Volpon L1, Culjkovic-Kraljacic B1, Osborne MJ1, Ramteke A1, Sun Q2, Niesman A2, Chook YM2, Borden KL3.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 May 10;113(19):5263-8. doi: 10.1073/pnas.1524291113. Epub 2016 Apr 25.
- Regulation of nuclear-cytoplasmic trafficking of oncoproteins is critical for growth homeostasis. Dysregulated trafficking contributes to malignancy, whereas understanding the process can reveal unique therapeutic opportunities. Here, we focus on eukaryotic translation initiation factor 4E (eIF4E),
- PMID 27114554
- Analysis of the interacting partners eIF4F and 3'-CITE required for MNSV cap-independent translation.
- Miras M1, Truniger V1, Querol-Audi J2, Aranda MA1.
- Molecular plant pathology.Mol Plant Pathol.2016 May 3. doi: 10.1111/mpp.12422. [Epub ahead of print]
- We previously showed that translation of Melon necrotic spot virus (MNSV, family Tombusviridae, genus Carmovirus) RNAs is controlled by a 3'-cap independent translation enhancer (CITE) which is genetically and functionally dependent on the eukaryotic translation initiation factor (eIF) 4E. Here we d
- PMID 27145354
Japanese Journal
- Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer
- Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats
- 4′,6-Dihydroxy-4-methoxyisoaurone Inhibits the HIF-1<i>α</i> Pathway Through Inhibition of Akt/mTOR/p70S6K/4E-BP1 Phosphorylation
Related Links
- MYC or eukaryotic translation initiation factor 4E (eIF4E) was required to bypass pharmacological PI3K/mTOR inhibition in resistant cells. Assessment of the prognostic value of high eIF4E mRNA in patient tumors found that
- eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein GeneRIFs: Gene References Into Functions Results of our study suggest that the eIF4E/Fmr1 double mutant mouse may be a reliable
- Eukaryotic translation initiation factor 4E (eIF4E) is perhaps best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. However, recent studies have highlighted that eIF4E has many additional ...
★リンクテーブル★
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- 英
- eukaryotic initiation factor-4E、eukaryotic translation initiation factor 4E、eIF4E、eIF-4E
- 関
- ・訳開始因子4E
[★]
- 関
- eIF-4E、eukaryotic initiation factor-4E、eukaryotic translation initiation factor 4E
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- 関
- eIF-4E、eIF4E、eukaryotic initiation factor-4E
[★]
- 英
- eukaryotic initiation factor-4E
- 関
- 真核生物・訳開始因子4E
[★]
- 関
- commence、commencement、evoke、initiate、institute、mount、onset、start
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- 関
- actual、actually、in fact、in practice、indeed、practically
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- 関
- element、elementary、factorial、parameter
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- 関
- eucaryote、eukaryote、eukaryotic organism