embryonal carcinoma

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胎児性癌

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/27 13:37:35」(JST)

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英文文献

  • Mitochondrial biogenesis and energy production in differentiating murine stem cells: a functional metabolic study.
  • Han S, Auger C, Thomas SC, Beites CL, Appanna VD.Author information 1 Department of Chemistry and Biochemistry, Laurentian University , Sudbury, Ontario P3E 2C6, Canada .AbstractAbstract The significance of metabolic networks in guiding the fate of the stem cell differentiation is only beginning to emerge. Oxidative metabolism has been suggested to play a major role during this process. Therefore, it is critical to understand the underlying mechanisms of metabolic alterations occurring in stem cells to manipulate the ultimate outcome of these pluripotent cells. Here, using P19 murine embryonal carcinoma cells as a model system, the role of mitochondrial biogenesis and the modulation of metabolic networks during dimethyl sulfoxide (DMSO)-induced differentiation are revealed. Blue native polyacrylamide gel electrophoresis (BN-PAGE) technology aided in profiling key enzymes, such as hexokinase (HK) [EC 2.7.1.1], glucose-6-phosphate isomerase (GPI) [EC 5.3.1.9], pyruvate kinase (PK) [EC 2.7.1.40], Complex I [EC 1.6.5.3], and Complex IV [EC 1.9.3.1], that are involved in the energy budget of the differentiated cells. Mitochondrial adenosine triphosphate (ATP) production was shown to be increased in DMSO-treated cells upon exposure to the tricarboxylic acid (TCA) cycle substrates, such as succinate and malate. The increased mitochondrial activity and biogenesis were further confirmed by immunofluorescence microscopy. Collectively, the results indicate that oxidative energy metabolism and mitochondrial biogenesis were sharply upregulated in DMSO-differentiated P19 cells. This functional metabolic and proteomic study provides further evidence that modulation of mitochondrial energy metabolism is a pivotal component of the cellular differentiation process and may dictate the final destiny of stem cells.
  • Cellular reprogramming.Cell Reprogram.2014 Feb;16(1):84-90. doi: 10.1089/cell.2013.0049. Epub 2013 Dec 19.
  • Abstract The significance of metabolic networks in guiding the fate of the stem cell differentiation is only beginning to emerge. Oxidative metabolism has been suggested to play a major role during this process. Therefore, it is critical to understand the underlying mechanisms of metabolic alteratio
  • PMID 24350892
  • microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells.
  • Huang H1, Tian H1, Duan Z1, Cao Y2, Zhang XS3, Sun F4.Author information 1Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.2Reproduction Medical Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.3Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.4Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China. Electronic address: feisun@ustc.edu.cn.AbstractMale germ cells with aberrant DNA damage are the weighted factor contributing to male infertility. Mounting evidence shows that DNA damage in male germ cells impairs spermatogenesis and lowers fecundity. MicroRNAs (miRNAs) regulating expression of multiple genes play a significant role in spermatogenesis. Our previous results have shown that microRNA-383 (miR-383) is one of the notable down-regulated microRNAs in the testes of sterile males with maturation arrest (MA) and is located predominantly in spermatogonia and primary spermatocytes. However, the role that miR-383 plays in DNA damage during spermatogenesis remains unknown. In this study, we found that miR-383 inhibited the focal formation and abundance of γH2AX, which is the major marker of sites of DNA damage, with or without ultraviolet irradiation and cisplatin in testicular embryonal carcinoma (NT-2) cells. In addition, NT-2 cells were remarkably sensitized to DNA damage reagent (cisplatin) by forcing expression of miR-383 and silencing expression of protein phosphatase 1, regulatory subunit 10 (PNUTS). By constructing Renilla luciferase reporters and co-transfecting miR-383 and reporters in NT-2 cells, we identified that PNUTS was a valid target of miR-383. Further results demonstrated that the repression of the phosphorylated form of H2AX by miR-383 was due to independent depletion of PNUTS and cell cycle arrest. In conclusion, we found a novel function of miR-383 in the DNA damage pathway. miR-383 impairs the phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest independently, as well as sensitizing NT-2 cells to cisplatin.
  • Cellular signalling.Cell Signal.2014 Jan 22. pii: S0898-6568(14)00035-7. doi: 10.1016/j.cellsig.2014.01.016. [Epub ahead of print]
  • Male germ cells with aberrant DNA damage are the weighted factor contributing to male infertility. Mounting evidence shows that DNA damage in male germ cells impairs spermatogenesis and lowers fecundity. MicroRNAs (miRNAs) regulating expression of multiple genes play a significant role in spermatoge
  • PMID 24462707
  • SHP-1 Arrests Mouse Early Embryo Development through Downregulation of Nanog by Dephosphorylation of STAT3.
  • Yin S1, Wu H1, Lv J1, Wu X1, Zhang Y1, Du J2, Zhang Y1.Author information 1College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China ; Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.2Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China ; College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.AbstractSrc-homology protein tyrosine phosphatase-1 (SHP-1) is a protein tyrosine phosphatase that is implicated in the regulation of growth, differentiation, survival, apoptosis and proliferation of hematopoietic cells and other cell types. Here, we found that SHP-1 is involved in regulation of early embryonic development. Embryos overexpressing SHP-1 were mainly arrested at the 8-cell stage, and Nanog mRNA expression was first observed in the morulae that showed down-regulation of SHP-1. These results suggested an antagonistic relationship between SHP-1 and Nanog during early embryonic development. Next, the specific mechanism was examined in mouse F9 embryonal carcinoma cells. We confirmed that signal transducer and activator of transcription 3 (STAT3) was a substrate for SHP-1 by co-immunoprecipitation. Using overexpression and knockdown strategies, we found that SHP-1 participated in regulation of Nanog expression. Furthermore, site mutation of STAT3 was performed to confirm that SHP-1 was responsible for rapid STAT3 dephosphorylation and a decrease of Nanog expression in F9 cells. These findings suggest that SHP-1 plays a crucial role during early embryonic development. Thus, SHP-1 may function as a key regulator for Nanog that specifically demarcates the nascent epiblast, coincident with the domain of X chromosome reprogramming.
  • PloS one.PLoS One.2014 Jan 21;9(1):e86330. doi: 10.1371/journal.pone.0086330. eCollection 2014.
  • Src-homology protein tyrosine phosphatase-1 (SHP-1) is a protein tyrosine phosphatase that is implicated in the regulation of growth, differentiation, survival, apoptosis and proliferation of hematopoietic cells and other cell types. Here, we found that SHP-1 is involved in regulation of early embry
  • PMID 24466030

和文文献

  • Simultaneous induction of calcium transients in embryoid bodies using microfabricated electrode substrates
  • TAKAYAMA Yuzo,SAITO Atsushi,MORIGUCHI Hiroyuki,KOTANI Kiyoshi,SUZUKI Takafumi,MABUCHI Kunihiko,JIMBO Yasuhiko
  • Journal of bioscience and bioengineering 112(6), 624-629, 2011-12-25
  • NAID 10030100250
  • Simultaneous induction of calcium transients in embryoid bodies using microfabricated electrode substrates(CELL AND TISSUE ENGINEERING)
  • Takayama Yuzo,Saito Atsushi,Moriguchi Hiroyuki,Kotani Kiyoshi,Suzuki Takafumi,Mabuchi Kunihiko,Jimbo Yasuhiko
  • Journal of bioscience and bioengineering 112(6), 624-629, 2011-12
  • … Mouse embryonal carcinoma P19 cells can be induced to differentiate into three germ layers and serve as a promising stem cell model. …
  • NAID 110008897340

関連リンク

Ovarian embryonal carcinoma [edit] In the ovary, embryonal carcinoma is quite rare, amounting to approximately three percent of ovarian germ cell tumours. The median age at diagnosis is 15 years. Symptoms and signs are varied ...
Intratubular embryonal carcinoma often present adjacent to invasive lesion, often with calcifications Stromal component suggests presence of teratoma Vascular invasion may be artifactual (loosely cohesive cells that don’t conform ...

関連画像

Embryonal carcinomaEmbryonal CarcinomaFile:Embryonal carcinoma - very high mag Embryonal Carcinomaembryonal carcinoma , medicalEmbryonal Carcinoma


★リンクテーブル★
国試過去問084A048
リンク元胚細胞腫瘍」「胎児性癌」「胚性がん腫」「胎芽性癌
拡張検索embryonal carcinoma cell」「embryonal carcinoma stem cell
関連記事carcinoma」「embryonal

084A048」

  [★]

  • 妊娠・分娩歴が診断上時に重要なのはどれ

胚細胞腫瘍」

  [★]

germ cell tumor GCT, germ cell tumors GCTs
生殖細胞腫瘍胚細胞性腫瘍胚細胞腫


脳における胚細胞腫瘍(SCN.194)

好発部位(SCN.194)

  • 松果体部(53%)、トルコ鞍上部(20%)、大脳基底核(5.5%) ← 正中線上に多い傾向
  • ジャーミノーマはトルコ鞍上部が多い

疫学(SCN.194)

  • 西欧と比べ、アジア、特に日本で多い。
  • 原発性脳腫瘍の約3%を占める
  • 小児に多い。小児脳腫瘍の15%を占める
  • 松果体に発生する腫瘍:男性に多い
  • トルコ鞍上部に発生する腫瘍:性差無し

症状(SCN.194)



胎児性癌」

  [★]

embryonal carcinoma
carcinoma embryonale
胎生癌、胚性癌腫、胎生期癌、胎生癌
卵巣胎児性癌、悪性胚細胞腫瘍



胚性がん腫」

  [★]

embryonal carcinoma
胚性癌腫胎児性癌


胎芽性癌」

  [★]

embryonal carcinoma
胎児性癌


embryonal carcinoma cell」

  [★]

embryonal cancer cellembryonal carcinoma stem cell


embryonal carcinoma stem cell」

  [★]

embryonal carcinoma cell


carcinoma」

  [★]

WordNet   license wordnet

「any malignant tumor derived from epithelial tissue; one of the four major types of cancer」

PrepTutorEJDIC   license prepejdic

「がん,がん腫」


embryonal」

  [★]

  • adj.
  • 胚性の、胎生期の、胎児性の
embryonicembryonic dayembryonic stageembryonicallyfetalfetal stage




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