cyclin-dependent kinase inhibitor

出典: meddic

サイクリン依存性キナーゼ阻害因子サイクリン依存性キナーゼインヒビターサイクリン依存性キナーゼ阻害分子CDKインヒビターCDK阻害因子

CDKICKIcyclin-dependent kinase inhibitor protein

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/18 21:20:34」(JST)

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英文文献

  • Selenium improves stem cell potency by stimulating the proliferation and active migration of 3T3-L1 preadipocytes.
  • Park SH, Kim JH, Nam SW, Kim BW, Kim GY, Kim WJ, Choi YH.SourceDepartment of Pathology, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea.
  • International journal of oncology.Int J Oncol.2014 Jan;44(1):336-342. doi: 10.3892/ijo.2013.2182. Epub 2013 Nov 15.
  • Selenium is a trace nutrient element that protects cells against oxidative damage. In this study, the potential of selenium to improve stem cell potency through active proliferation and migration of 3T3-L1 preadipocytes was investigated, together with the underlying molecular mechanisms. The results
  • PMID 24247590
  • Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest.
  • Wang D, Sun SQ, Yu YH, Wu WZ, Yang SL, Tan JM.SourceDepartment of Urology, Fuzhou General Hospital, Fuzhou 350025, P.R. China.
  • International journal of oncology.Int J Oncol.2014 Jan;44(1):161-166. doi: 10.3892/ijo.2013.2170. Epub 2013 Nov 8.
  • SCIN is a calcium regulated actin severing and capping protein. Its homologue in zebrafish is found to be related with cell death. In the present study, we found that SCIN is highly expressed in human prostate cancer specimens. However, the functions of SCIN in human prostate carcinoma cells are lar
  • PMID 24212916
  • Cyclin-dependent kinase 1 inhibitor RO3306 promotes mitotic slippage in paclitaxel-treated HepG2 cells.
  • Xiao J, Qiu P, Lai X, He P, Wu Y, Du B, Tan Y.AbstractHepatocellular carcinoma (HCC) is the most common primary liver neoplasm and current systemic chemotherapy are mostly ineffective. Paclitaxel (PTX) has a clinically significant effect on many malignant tumors. Cells treated with PTX undergo reversible mitotic arrest and although high doses can cause side effects it may also induce apoptosis. We investigated the effect of a sequential combination of PTX and RO3306, a cyclin-dependent kinase 1 inhibitor, on the hepatocellular carcinoma HepG2 cell line. The sequential drug treatment protocol involved the addition of PTX (0.2 µmol/L) for 18 h followed by RO3306 (2 µmol/L) for a further 6 h. Cell viability and proliferation were measured using tetrazolium dye (MTT) and colony formation assay. Cell cycle profiles were established by flow cytometry. The expression level of protein was examined by immunoblotting. We observed a synergistic effect of PTX and RO3306 treatment on cell growth and proliferation as well as an increased proportion of cells in sub-G1 phase. Expression levels of cyclin B, cyclin E and phosphorylated Histone H3 demonstrated that RO3306 enhanced apoptosis in PTX treated cells by mitotic slippage. Our data suggested that the combination of PTX and RO3306 may be an effective therapeutic combination for the treatment of liver cancer. Keywords: paclitaxel; RO3306; apoptosis; mitotic slippage; HepG2 cells.
  • Neoplasma.Neoplasma.2014;61(1):41-7.
  • Hepatocellular carcinoma (HCC) is the most common primary liver neoplasm and current systemic chemotherapy are mostly ineffective. Paclitaxel (PTX) has a clinically significant effect on many malignant tumors. Cells treated with PTX undergo reversible mitotic arrest and although high doses can cau
  • PMID 24195507

和文文献

  • Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells
  • HE Wei,WANG Bin,ZHUANG Yun,SHAO Dong,SUN Kewen,CHEN Jianping
  • Journal of pharmacological sciences 119(4), 341-348, 2012-08-20
  • … Here we report that in vitro treatment of human cholangiocarcinoma QBC939 cells with berberine, a naturally occurring isoquinoline alkaloid, decreased cell viability and induced cell death in a dose-dependent manner, which was associated with an increase in G1 arrest. … Our western blot analysis showed that berberine-induced G1 cell cycle arrest was mediated through the increased expression of cyclin-dependent kinase inhibitors (Cdki) proteins (Cip1/p21 and Kip1/p27); …
  • NAID 10031071516
  • IMMUNOHISTOCHEMICAL ANALYSIS OF THE CELL CYCLE-ASSOCIATED PROTEINS IN DIFFUSE LARGE B-CELL LYMPHOMA
  • 梅村 宜弘,本間 まゆみ,塩沢 英輔,矢持 淑子,瀧本 雅文,太田 秀一
  • 昭和医学会雑誌 72(1), 2012
  • … Skp2 positively regulates the G1-S transition by promoting degradation of the cyclin-dependent kinase inhibitor p27. …
  • NAID 130002582881

関連リンク

New and Potent CDK inhibitors are available. Including Cyclin-Dependent Kinase inhibitor drugs in clinical trials. Order from Supplier Adooq ... A10093 AT7519 AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs ...
^Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature 382 (6589): 325–31. doi:10.1038/382325a0. ...

関連画像

Cyclin-dependent kinase inhibitor complexcyclin - dependent kinaseCyclin-dependent kinase inhibitor complexp16 and p21 protein expressioncyclin - dependent kinasesCyclin - dependent Kinase 2


★リンクテーブル★
リンク元サイクリン依存性キナーゼインヒビター」「CDK阻害因子」「CDKインヒビター」「サイクリン依存性キナーゼ阻害因子」「サイクリン依存性キナーゼ阻害分子
拡張検索cyclin-dependent kinase inhibitors」「cyclin-dependent kinase inhibitor p19」「cyclin-dependent kinase inhibitor p21」「cyclin-dependent kinase inhibitor p27」「cyclin-dependent kinase inhibitor p57
関連記事inhibit」「dependent」「inhibitor」「kinase」「kina

サイクリン依存性キナーゼインヒビター」

  [★]

cyclin-dependent kinase inhibitorcyclin-dependent kinase inhibitor protein
サイクリン依存性キナーゼ阻害因子サイクリン依存性キナーゼ阻害分子CDKインヒビターCDK阻害因子


CDK阻害因子」

  [★]

cyclin-dependent kinase inhibitor
サイクリン依存性キナーゼ阻害因子サイクリン依存性キナーゼインヒビターサイクリン依存性キナーゼ阻害分子CDKインヒビター


CDKインヒビター」

  [★]

cyclin-dependent kinase inhibitor
サイクリン依存性キナーゼ阻害因子サイクリン依存性キナーゼインヒビターサイクリン依存性キナーゼ阻害分子CDK阻害因子


サイクリン依存性キナーゼ阻害因子」

  [★]

cyclin-dependent kinase inhibitorCKICDKI
サイクリン依存性キナーゼインヒビターサイクリン依存性キナーゼ阻害分子CDKインヒビターCDK阻害因子


サイクリン依存性キナーゼ阻害分子」

  [★]

cyclin-dependent kinase inhibitor
サイクリン依存性キナーゼ阻害因子サイクリン依存性キナーゼインヒビターCDKインヒビターCDK阻害因子


cyclin-dependent kinase inhibitors」

  [★] サイクリン依存性キナーゼ阻害因子 CDKIs


cyclin-dependent kinase inhibitor p19」

  [★]

サイクリン依存性キナーゼ阻害因子p19


cyclin-dependent kinase inhibitor p21」

  [★]

サイクリン依存性キナーゼ阻害因子p21


cyclin-dependent kinase inhibitor p27」

  [★]

サイクリン依存性キナーゼ阻害因子p27


cyclin-dependent kinase inhibitor p57」

  [★]

サイクリン依存性キナーゼ阻害因子p57


inhibit」

  [★]

  • v.
  • 抑制する、阻害する、阻止する
abrogateblockdepressdepressiondeterinhibitioninterdictpreventpreventionrepressrepressionrestrainrestraintsuppresssuppression

WordNet   license wordnet

「limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"」

PrepTutorEJDIC   license prepejdic

「〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》」

WordNet   license wordnet

「control and refrain from showing; of emotions, desires, impulses, or behavior」
bottle up, suppress

WordNet   license wordnet

「limit the range or extent of; "Contact between the young was inhibited by strict social customs"」


dependent」

  [★]

  • adj.
  • 依存性の、依存的な、依存型の、依存の
dependdependencedependencydependently

WordNet   license wordnet

「relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"」

PrepTutorEJDIC   license prepejdic

「『頼っている』,依存している,従属している / 扶養される人(家族)」

WordNet   license wordnet

「addicted to a drug」
dependant, drug-addicted, hooked, strung-out

WordNet   license wordnet

「contingent on something else」
dependant, qualified

WordNet   license wordnet

「(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence"」
subordinate


inhibitor」

  [★]

  • n.
blockerdepressantsuppressant

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」


kinase」

  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

WordNet   license wordnet

「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」


kina」

  [★]

WordNet   license wordnet

「the basic unit of money in Papua New Guinea」




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