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- 1. HIV陰性患者における非結核性抗酸菌感染症の概要 overview of nontuberculous mycobacterial infections in hiv negative patients
- 2. HIV感染患者におけるMycobacterium avium complex (MAC）感染症 mycobacterium avium complex mac infections in hiv infected patients
- 3. HIV陰性患者における肺非結核性抗酸菌感染症の治療 treatment of nontuberculous mycobacterial infections of the lung in hiv negative patients
- 4. 非結核性抗酸菌の微生物学 microbiology of nontuberculous mycobacteria
- 5. 非結核性抗酸菌感染症の疫学 epidemiology of nontuberculous mycobacterial infections
- Changes in serum immunomolecules during antibiotic therapy for Mycobacterium avium complex lung disease.
- Kim SY1, Koh WJ, Park HY, Jeon K, Kwon OJ, Cho SN, Shin SJ.Author information 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.AbstractLittle information is available regarding changes in immune status for patients with Mycobacterium avium complex (MAC) lung disease during antibiotic therapy. Serum immunomolecules from 42 patients with MAC lung disease were assayed comparatively using an array-based system according to (i) patients with MAC lung disease at the time of diagnosis versus healthy controls and (ii) alterations after 12 months of antibiotic therapy in the MAC lung disease group. In addition, cytokine analyses were performed to determine whether cytokine responses were associated specifically with the disease phenotype, treatment outcome and aetiological agent. Notably, the serum concentrations of type 1 cytokine-associated molecules, such as CD40L, interferon (IFN)-γ, interleukin (IL)-8 and IL-23, were decreased significantly in patients at the time of diagnosis, suggesting that these molecules may serve as indicators of host susceptibility to MAC disease. Although the overall serum level of T helper type 1 (Th1)-related molecules, such as CD40L and IFN-γ, was restored after treatment, Th17-related cytokines, such as IL-17 and IL-23, were down-regulated significantly at 12 months post-treatment compared to pretreatment. Furthermore, these cytokine patterns differed among patient subgroups. Decreased serum concentrations of IL-17 and/or IL-23 were associated with failure of sputum conversion, the fibrocavitary disease phenotype and M. intracellulare lung disease. Thus, the reciprocal balance between Th1 and Th17 immunity during antibiotic therapy for MAC lung disease is critical for dictating the treatment response. In conclusion, a low level of Th1-related immunomolecules may perpetuate MAC lung disease, and the serum concentrations of Th17-related cytokines can reflect the treatment outcome, disease phenotype and aetiological agent.
- Clinical and experimental immunology.Clin Exp Immunol.2014 Apr;176(1):93-101. doi: 10.1111/cei.12253.
- Little information is available regarding changes in immune status for patients with Mycobacterium avium complex (MAC) lung disease during antibiotic therapy. Serum immunomolecules from 42 patients with MAC lung disease were assayed comparatively using an array-based system according to (i) patients
- PMID 24354934
- Mycobacterium avium Complex in Day Care Hot Water Systems, and Persistence of Live Cells and DNA in Hot Water Pipes.
- Bukh AS1, Roslev P.Author information 1Section of Biology and Environmental Science, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000, Alborg, Denmark.AbstractThe Mycobacterium avium complex (MAC) is a group of opportunistic human pathogens that may thrive in engineered water systems. MAC has been shown to occur in drinking water supplies based on surface water, but less is known about the occurrence and persistence of live cells and DNA in public hot water systems based on groundwater. In this study, we examined the occurrence of MAC in hot water systems of public day care centers and determined the persistence of live and dead M. avium cells and naked DNA in model systems with the modern plumbing material cross-linked polyethylene (PEX). The occurrence of MAC and co-occurrence of Legionella spp. and Legionella pneumophila were determined using cultivation and qPCR. Co-occurrences of MAC and Legionella were detected in water and/or biofilms in all hot water systems at temperatures between 40 and 54 °C. Moderate correlations were observed between abundance of culturable MAC and that of MAC genome copies, and between MAC and total eubacterial genome copies. No quantitative relationship was observed between occurrence of Legionella and that of MAC. Persistence in hot water of live and dead M. avium cells and naked DNA was studied using PEX laboratory model systems at 44 °C. Naked DNA and DNA in dead M. avium cells persisted for weeks. Live M. avium increased tenfold in water and biofilms on PEX. The results suggest that water and biofilms in groundwater-based hot water systems can constitute reservoirs of MAC, and that amplifiable naked DNA is relatively short-lived, whereas PEX plumbing material supports persistence and proliferation of M. avium.
- Current microbiology.Curr Microbiol.2014 Apr;68(4):428-39. doi: 10.1007/s00284-013-0493-4. Epub 2013 Nov 23.
- The Mycobacterium avium complex (MAC) is a group of opportunistic human pathogens that may thrive in engineered water systems. MAC has been shown to occur in drinking water supplies based on surface water, but less is known about the occurrence and persistence of live cells and DNA in public hot wat
- PMID 24272032
- In Vitro Activity of Amikacin against Isolates of Mycobacterium avium Complex with Proposed MIC Breakpoints and Finding of a 16S rRNA Gene Mutation in Treated Isolates.
- Brown-Elliott BA1, Iakhiaeva E, Griffith DE, Woods GL, Stout JE, Wolfe CR, Turenne CY, Wallace RJ Jr.
- Journal of clinical microbiology.J Clin Microbiol.2014 Apr;52(4):1311. doi: 10.1128/JCM.00224-14.
- PMID 24619984
- 肺野末梢に孤立性結節影を呈した Mycobacterium avium intracellulare complex (MAC) 肺感染症に腺癌を合併した1例
- 太田 英樹,河合 秀樹
- 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 26(4), 481-485, 2012-05-15
- NAID 10030435876
- 本野 望,保坂 靖子,富樫 賢一
- 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 26(1), 17-20, 2012-01-15
- NAID 10030025912
- Mycobacterium avium complex (MAC) is a group of genetically related bacteria belonging to the genus Mycobacterium. ... R3: M. avium complex/Mycobacterium avium/Mycobacterium intracellulare/MAP (MAI infection) · M. ulcerans (Buruli ...
- Mycobacterium avium-intracellulare (MAI) is an atypical mycobacterial infection which can occur in the later stages of AIDS. It can also ... "Lady Windermere syndrome" describes infection in the lungs due to Mycobacterium avium complex .
|先読み||「Mycobacterium intracellulare」「Mycobacterium avium complex」|
- Mycobacterium intracellulare、M. intracellulare
- Mycobacterium avium complex、Mycobacterium avium-intracellulare complex, MAC
- Mycobacterium avium complex、Mycobacterium avium-intracellulare complex、Mycobacterium intracellulare
- Mycobacterium avium-intracellulare complex
- adv. intracellularly