MSH

出典: meddic

メラニン細胞刺激ホルモン

See Melanocyte-stimulating hormone
melanocyte-stimulating hormone,メラニン細胞刺激ホルモン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/09 20:33:46」(JST)

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英文文献

  • Automated docking studies provide insights into molecular determinants of ligand recognition by N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB).
  • Huang X, Hernick M.Author information Department of Biochemistry, Virginia Tech, Blacksburg, VA, 24061.AbstractThe metal-dependent deacetylase N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB) catalyzes the deacetylation of N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside (GlcNAc-Ins), the committed step in mycothiol (MSH) biosynthesis. MSH is the thiol redox buffer used by mycobacteria to protect against oxidative damage and is involved in the detoxification of xenobiotics. As such, MshB is a target for the discovery of new drugs to treat tuberculosis (TB). While MshB substrate specificity and inhibitor activity have been probed extensively using enzyme kinetics, information regarding the molecular basis for the observed differences in substrate specificity and inhibitor activity is lacking. Herein we begin to examine the molecular determinants of MshB substrate specificity using automated docking studies with a set of known MshB substrates. Results from these studies offer insights into molecular recognition by MshB via identification of side chains and dynamic loops that may play roles in ligand binding. Additionally, results from these studies suggest that a hydrophobic cavity adjacent to the active site may be one important determinant of MshB substrate specificity. Importantly, this hydrophobic cavity may be advantageous for the design of MshB inhibitors with high affinity and specificity as potential TB drugs. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 406-417, 2014.
  • Biopolymers.Biopolymers.2014 Apr;101(4):406-17. doi: 10.1002/bip.22397.
  • The metal-dependent deacetylase N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB) catalyzes the deacetylation of N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside (GlcNAc-Ins), the committed step in mycothiol (MSH) biosynthesis. MSH is the thiol redox buf
  • PMID 24037975
  • Efficacy of the melanocortin analogue Nle4-D-Phe7-α-melanocyte-stimulating hormone in the treatment of patients with Hailey-Hailey disease.
  • Biolcati G, Aurizi C, Barbieri L, Cialfi S, Screpanti I, Talora C.Author information Porphyria Center, San Gallicano Institute IRCCS, Rome, Italy.AbstractBACKGROUND: Hailey-Hailey disease (HHD) is a rare, chronic and recurrent blistering disorder, which is characterized clinically by erosions occurring primarily in intertriginous regions, and histologically by suprabasal acantholysis. Oxidative stress plays a specific role in the pathogenesis of HHD, by regulating the expression of factors playing an important role in keratinocyte proliferation and differentiation.
  • Clinical and experimental dermatology.Clin Exp Dermatol.2014 Mar;39(2):168-175. doi: 10.1111/ced.12203. Epub 2013 Oct 25.
  • BACKGROUND: Hailey-Hailey disease (HHD) is a rare, chronic and recurrent blistering disorder, which is characterized clinically by erosions occurring primarily in intertriginous regions, and histologically by suprabasal acantholysis. Oxidative stress plays a specific role in the pathogenesis of HHD,
  • PMID 24256215
  • Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.
  • Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, Neri L, Cavallini GM, Altavilla D, Botticelli AR, Squadrito F, Guarini S.Author information Department of Biomedical, Metabolic and Neural Sciences, Section of Pharmacology and Molecular Medicine, University of Modena and Reggio Emilia, Modena, Italy.AbstractBesides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in occasional studies performed in AD-type dementia patients. Here we investigated the possible neuroprotective role of melanocortins in a chronic neurodegenerative disorder, AD, by using 12-week-old (at the start of the study) triple-transgenic (3xTg-AD) mice harboring human transgenes APPSwe, PS1M146V, and tauP301L. Treatment of 3xTg-AD mice, once daily until the end of the study (30 weeks of age), with the melanocortin analog [Nle(4),D-Phe(7)]-α-melanocyte-stimulating hormone (NDP-α-MSH) reduced cerebral cortex/hippocampus phosphorylation/level of all AD-related biomarkers investigated (mediators of amyloid/tau cascade, oxidative/nitrosative stress, inflammation, apoptosis), decreased neuronal loss, induced over-expression of the synaptic activity-dependent gene Zif268, and improved cognitive functions, relative to saline-treated 3xTg-AD mice. Pharmacological blockade of melanocortin MC4 receptors prevented all neuroprotective effects of NDP-α-MSH. Our study identifies, for the first time, a class of drugs, MC4 receptor-stimulating melanocortins, that are able to counteract the progression of experimental AD by targeting pathophysiological mechanisms up- and down-stream of β-amyloid and tau. These data could have important clinical implications.
  • Neurobiology of aging.Neurobiol Aging.2014 Mar;35(3):537-47. doi: 10.1016/j.neurobiolaging.2013.08.030. Epub 2013 Oct 1.
  • Besides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in
  • PMID 24094579

和文文献

  • Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus
  • YAMADA Masayoshi,NAKAMURA Kazuhiko,WATABE Taeko,OHNO Osamu,KAWAGOSHI Masaru,MARU Norihito,UOTSU Nobuo,CHIBA Tomohiro,YAMAGUCHI Kohji,UEMURA Daisuke
  • Bioscience, biotechnology, and biochemistry 75(8), 1628-1630, 2011-08-23
  • … The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. …
  • NAID 10029592041
  • SF-032-4 Promoter methylation analysis of MLH1, MSH2, and MGMT in colorectal cancer is associated with the adenoma-carcinoma sequence
  • Park Chan Yong
  • 日本外科学会雑誌 112(臨時増刊号_1・2), 375, 2011-05-25
  • NAID 110008683815

関連リンク

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硬式野球をしながら柔道整復師を目指すMSH医療専門学校。学校案内、学科紹介、施設紹介等。 ... 本校の学科において卒業認定を受けた人で国家試験に万一合格できなかった場合学費免除で引き続き資格取得の勉学をできる制度です。

関連画像

msh logoMSH Brain Flybarless-System proste > Szlifierka prosta MSh 636-1MSH-236 División AudioHome » MSH Brain Adhesive tape [MSH51604]MSH-X8A Sony : Avec 8GB de mémoire, le


★リンクテーブル★
リンク元脆弱X症候群」「メラニン」「メラノサイト」「メラニン細胞刺激ホルモン」「intermedin
拡張検索MSH放出ホルモン」「MSH放出抑制ホルモン
関連記事M」「MS

脆弱X症候群」

  [★]

fragile X syndrome FRAXA
脆弱X染色体症候群
MSH 2遺伝子 MSH


概念

  • 定義:FMR-1遺伝子がコードしているFMR-1タンパクの低下、欠損によるX連鎖遺伝性精神遅滞(PED.219)

病因

  • FMR-1遺伝子の5'末端UTR上のCGGリピートが増加することによる
Xq27.3にマップされる
CGGリピート
正常:29
前突然変異:52-200
完全突然変異:230-4000
  • プロモーター領域のCpGがメチル化を受けるために、FMR-1の発現が抑制されることによる

疫学

  • 原因の判明している精神遅滞の中ではダウン症候群に次いで多い
  • 欧米では一般男性1/4,000人,女性1/10,000人。(♂1,500人対1人、♀2,500人対1人(PED.219)
  • 脆弱X突然変異を有する人の中で男性の20%が無症状、女性の30%に軽度の知的障害が認められる。

遺伝形式

  • 表現促進現象

病変形成&病理

症状

  • 精神遅滞,細長い顔,突出した下顎,大耳介,小児期の自閉・多動,思春期以降の巨大睾丸(80%)
  • 精神遅滞の2大原因は脆弱X症候群とダウン症候群

診断

検査

治療

予後

予防

メラニン」

  [★]

melanin
メラニン色素 melanin pigment
メラノサイトメラノソーム


産生細胞

産生機序

  • チロシナーゼ(補酵素:銅)の作用によってチロシンから生じるドパが酸化、脱炭酸を経て、産生される

産生の制御

促進

MRI

  • T1強調画像で高信号を呈する。


メラノサイト」

  [★]

melanocyte
melanocytus
メラニン


メラニン合成促進する要素


メラニン細胞刺激ホルモン」

  [★]

melanocyte-stimulating hormone melanocyte stimulating hormone, MSH
メラノトロピン melanotropin


intermedin」

  [★]

インターメジンメラニン細胞刺激ホルモン

melanocyte-stimulating hormonemelanotropinMSH


MSH放出ホルモン」

  [★]

MSH-releasing hormone
メラニン細胞刺激ホルモン放出ホルモン


MSH放出抑制ホルモン」

  [★]

MSH release-inhibiting hormoneMIF-1


M」

  [★] メチオニン methionine

WordNet   license wordnet

「the 13th letter of the Roman alphabet」
m

PrepTutorEJDIC   license prepejdic

「Mach number / mark[s] / Monsieur」


MS」

  [★]

PrepTutorEJDIC   license prepejdic

「Mississippi」


"http://meddic.jp/MSH" より作成


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