WordNet

a skin problem marked by the development (on the eyelids and neck and back) of irregular yellow nodules; sometimes attributable to disturbances of cholesterol metabolism
widespread xanthomas (especially on elbows and knees); often associated with a disorder of lipid metabolism (同)xanthoma multiplex, cholesterosis cutis, lipid granulomatosis, lipoid granulomatosis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/01 16:33:00」(JST)

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A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek xanthos, ξανθος, "yellow", is a deposition of yellowish cholesterol-rich material in tendons or other body parts in various disease states.^[1] They are cutaneous manifestations of lipidosis in which there is an accumulation of lipids in large foam cells within the skin.^[1]

They are associated with hyperlipidemias, both primary and secondary types.

Tendon xanthomas are associated with Type II hyperlipidemia, chronic biliary tract obstruction, and primary biliary cirrhosis.

Palmar xanthomata and tuboeruptive xanthomata (over knees and elbows) occur in Type III hyperlipidaemia

Types

Xanthelasma

Histology picture of xanthoma showing lipid laden foam cells with large areas of cholesterol clefts, 10 × magnification, eosin and hematoxilin stain. Kumar et al. Cases Journal 2008

A xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, only being called a xanthoma when becoming larger and nodular, assuming tumorous proportions.^[2] Still, it is often classified simply as a subtype of xanthoma.^[3]

Xanthoma tuberosum

Xanthoma tuberosum (also known as tuberous xanthoma) is characterized by xanthomas located over the joints.^[1]^:530

Xanthoma tendinosum

Xanthoma tendinosum (also tendon xanthoma or tendinous xanthoma^[4]) is clinically characterized by papules and nodules found in the tendons of the hands, feet, and achilles.^[1]^:531 Also associated with familial hypercholesterolemia (FH).^[5]

Eruptive xanthoma

Eruptive xanthoma (ILDS E78.220) is clinically characterized by small, yellowish-orange to reddish-brown papules that appear all over the body.^[1]^:531 It tends to be associated with elevated triglycerides ^[6]

Xanthoma planum

Xanthoma planum (ILDS D76.370), also known as "Plane xanthoma", is clinically characterized by macules and plaques spread diffusely over large areas of the body.^[1]^:531

Palmar xanthoma

Palmar xanthoma is clinically characterized by yellowish plaques that involve the palms and flexural surfaces of the fingers.^[1]^:531 Plane xanthomas are characterised by yellowish to orange, flat macules or slightly elevated plaques, often with a central white area which may be localised or generalised. They often arise in the skin folds, especially the palmar creases. They occur in hyperlipoproteinaemia type III and type IIA, and in association with biliary cirrhosis. The presence of palmar xanthomata, like the presence of tendinous xanthomata, is indicative of hypercholesterolaemia.

Tuberoeruptive xanthoma

Tuberoeruptive xanthoma (ILDS E78.210) is clinically characterized by red papules and nodules that appear inflamed and tend to coalesce.^[1]^:532 Tuberous xanthomas are considered similar, and within the same disease spectrum as eruptive xanthomas.^[4]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Shields, Carol; Shields, Jerry (2008). Eyelid, conjunctival, and orbital tumors: atlas and textbook. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7578-7.
^ thefreedictionary.com > xanthelasma Citing: The American Heritage Medical Dictionary Copyright 2007, 2004 and Mosby's Medical Dictionary, 8th edition. 2009
^ ^a ^b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1415–16. ISBN 1-4160-2999-0.
^ Van Den Bosch, Harrie C.M.; van den Bosch, Harrie C.M. and D. Vos, Louwerens (May 28, 1998). "Achilles'-Tendon Xanthoma in Familial Hypercholesterolemia". New England Journal of Medicine 338 (22): 1591. doi:10.1056/NEJM199805283382205. PMID 9603797. Retrieved 5 April 2013. Cite uses deprecated parameters (help)
^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030216/

External links

Look up xanthoma in Wiktionary, the free dictionary.

Media related to xanthoma at Wikimedia Commons
194641940 at GPnotebook
MedlinePlus Encyclopedia Xanthoma

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 脳腱黄色腫症 cerebrotendinous xanthomatosis
2. 高トリグリセリド血症患者に対するアプローチ approach to the patient with hypertriglyceridemia
3. 若年性黄色肉芽腫（JXG） juvenile xanthogranuloma jxg
4. ガングリオンと結節 ganglia and nodules
5. 原発性胆汁性肝硬変の治療の概要 overview of the treatment of primary biliary cirrhosis

English Journal

POEMS syndrome (polyneuropathy organomegaly endocrinopathy M-protein skin changes) with xanthoma - a case report.

Kutlubay Z1, Engin B1, Uzuncakmak TK1, Demirkesen C2, Altiti MM3, Karter Y3, Tuzun Y1.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2016 Feb;30(2):353-5. doi: 10.1111/jdv.12766. Epub 2014 Oct 8.
PMID 25296893

Plaque-like papular xanthoma: a new variant of non-Langerhans cell disease.

Coutinho I1, Moreira S2, Ramos L1, Robalo Cordeiro M1, Cardoso J1, Gonçalo M1, Tellechea O1.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2016 Feb;30(2):332-3. doi: 10.1111/jdv.12725. Epub 2014 Sep 26.
PMID 25258297

A rare case of disseminated skin and mucosal necrobiotic xanthogranuloma and xanthoma.

AlGain M1,2, Szalat R2,3,4, Vignon-Pennamen MD2,3,5, Malphettes M2,3,4, Vignon M2,3,4, de Masson A1,2, Bagot M1,2, Rybojad M1,2,4, Asli B2,3,4, Arnulf B2,3,4, Bouaziz JD1,2,4.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2016 Jan 25. doi: 10.1111/jdv.13577. [Epub ahead of print]
PMID 26810089

Japanese Journal

症例報告 Verruciform xanthomaの1例 : ヒト乳頭腫ウイルスとの関連性について

篠原理恵,上野誠,福本瞳 [他]
臨床皮膚科 68(4), 339-342, 2014-04
NAID 40020064092

多発性口内炎と疣贅型黄色腫を併発した1例

清河年彦,重松久夫,奥結香 [他]
日本口腔科学会雑誌 63(2), 226-232, 2014-03
NAID 40020072438

Hepatic Xanthoma Associated with Pasireotide Administration: A First Case Report

Meng Fan-Chun,Chao Tai-Kuang,Huang Hsin-Hung
Internal Medicine 52(19), 2219-2223, 2013
… Hepatic xanthoma is an extremely rare lesion worldwide. … We herein present a case of hepatic xanthoma that developed in a 27-year-old Taiwanese man who had participated in a clinical trial of pasireotide. … This is, to the best of our knowledge, the first case of pasireotide-induced hepatic xanthoma. …
NAID 130003392592

Related Pictures

★リンクテーブル★

リンク元	「黄色腫」「xanthomatosis」
関連記事	「xantho」

「黄色腫」

Xanthoma
	Classification and external resources
	Photograph of patient's knee showing multiple xanthoma tuberosum. Kumar et al. Cases Journal 2008
ICD-10	E78.2 (ILDS E78.280), K13.4
ICD-9	272.2
DiseasesDB	28524
MedlinePlus	001447
MeSH	D014973

　　[★]

英: xanthoma, xanthomas, xanthomata
同: 黄色板症 xanthelasma、コレステリン沈着症 cholesterolosis
関: 家族性高リポ蛋白血症II型

国試

097F022

「xanthomatosis」

　　[★]

黄色腫症

関: xanthoma

「xantho」

　　[★]

黄色

関: xanthic、yellow

[Andrews-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

[2] Shields, Carol; Shields, Jerry (2008). Eyelid, conjunctival, and orbital tumors: atlas and textbook. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7578-7.

[3] thefreedictionary.com > xanthelasma Citing: The American Heritage Medical Dictionary Copyright 2007, 2004 and Mosby's Medical Dictionary, 8th edition. 2009

[Bolognia-4] Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1415–16. ISBN 1-4160-2999-0.

[5] Van Den Bosch, Harrie C.M.; van den Bosch, Harrie C.M. and D. Vos, Louwerens (May 28, 1998). "Achilles'-Tendon Xanthoma in Familial Hypercholesterolemia". New England Journal of Medicine 338 (22): 1591. doi:10.1056/NEJM199805283382205. PMID 9603797. Retrieved 5 April 2013. Cite uses deprecated parameters (help)

[6] ttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030216/

匿名

検索

案内

案内

xanthoma