WordNet

(psychiatry) a relatively permanent state of worry and nervousness occurring in a variety of mental disorders, usually accompanied by compulsive behavior or attacks of panic (同)anxiousness
a vague unpleasant emotion that is experienced in anticipation of some (usually ill-defined) misfortune
to exert strenuous effort against opposition; "he struggled to get free from the rope"
an energetic attempt to achieve something; "getting through the crowd was a real struggle"; "he fought a battle for recognition" (同)battle
strenuous effort; "the struggle to get through the crowd exhausted her"
suffer great pains or distress
extreme distress of body or mind
extreme mental distress (同)torment, torture

PrepTutorEJDIC

〈U〉(…についての)『心配』,不安,気がかり《+『about(for)』+『名』》 / 〈C〉心配事,心配の種 / 〈U〉《話》『切望』,熱望;〈C〉切望する事(物)
『もがく』,あがく / 『戦う』,奮闘する / 《a~》『非常な努力』,奮闘 / 『戦い』,闘争
(…に対する)(心身の)『激しい苦しみ』,苦悶(くもん)《+『over』+『名』》 / …‘に'苦悶させる / (…に)苦悶する《+『over』+『名』》

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Anti-hyperalgesic activity of crude extract and 7-methyljuglone of Diospyros lotus roots.

Rauf A1, Uddin G1, Khan H2, Siddiqui BS3, Arfan M1.
Natural product research.Nat Prod Res.2015 Dec;29(23):2226-9. doi: 10.1080/14786419.2014.1003297. Epub 2015 Jan 21.
This study was designed to evaluate the antihyperalgesic effect of crude extract of Diospyros lotus followed by the isolation and characterisation of 7-methyljuglone in acetic acid and formalin tests. The pretreatment of crude extract evoked dose-dependent inhibition of noxious stimulation with maxi
PMID 25604725

Anti-inflammatory and antinociceptive effects of racemic goniothalamin, a styryl lactone.

Vendramini-Costa DB1, Spindola HM2, de Mello GC3, Antunes E3, Pilli RA4, de Carvalho JE5.
Life sciences.Life Sci.2015 Oct 15;139:83-90. doi: 10.1016/j.lfs.2015.08.010. Epub 2015 Aug 19.
AIMS: The present study aimed to further investigate the anti-inflammatory activity of goniothalamin (GTN), a styryl lactone, as well as its antinociceptive effects.MAIN METHODS: The anti-inflammatory activity was evaluated in models of paw edema induced by different mediators in mice and carrageena
PMID 26297443

The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

Tomic MA1, Pecikoza UB, Micov AM, Stepanovic-Petrovic RM.
Anesthesia and analgesia.Anesth Analg.2015 Oct 13. [Epub ahead of print]
BACKGROUND: Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may be useful in relieving these pain states. Eslicarbazepine acetate (ESL) is a no
PMID 26465930