出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/06 14:16:57」(JST)
Names | |
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Other names
(3β,4β,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3yl 3,4-dimethoxybenzoate
3-Veratroylveracevine |
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Identifiers | |
CAS Registry Number
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71-62-5 Y |
ChEMBL | ChEMBL451227 N |
ChemSpider | 5290571 N |
InChI
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IUPHAR/BPS
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2626 |
Jmol-3D images | Image |
PubChem | 6914694 |
SMILES
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Properties | |
Chemical formula
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C36H51NO11 |
Molar mass | 673.80 g·mol−1 |
Melting point | 160 to 180 °C (320 to 356 °F; 433 to 453 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) | |
Infobox references | |
Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by abolishing inactivation of sodium ion channels.[1] It is primarily obtained from the herb Veratrum and sabadilla seeds. It binds to intramembrane receptor site 2 and increases intracellular Ca2+ concentration. It acts by preferentially binding to activated Na+ channels causing persistent activation that leads to increased nerve excitability.
Isolated from seeds of Schoenocaulon officinale, and from rhizomes of Veratrum album.[2]
Veratridine is a derivative, the 3-veratroate ester, of veracevine, which belongs to the class of C-nor-D-homosteroidal alkaloids. The molecular structure and stereochemistry of this and related alkaloids were only established after decades of chemical investigations.[3] The structure of veratridine has been confirmed by NMR spectroscopy[4] and X-ray crystallography.[5]
It is used in ointments for the treatment of neuralgia and rheumatoid pain.[citation needed]
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リンク元 | 「神経筋接合部」「ベラトリジン」 |
+ | - | |
神経活動電位発生 | tetrodotoxin | |
batrachotoxin | ||
アセチルコリン放出 | excess of Ca2+ | hemicholinium |
botulinus toxin | ||
procaine | ||
Mg2+ | ||
4-aminopyridine | ||
lack of Ca2+ | ||
終板電位発生 | succinylcholine(suxamethonium) | curare alkaloids |
decamethonium | α-toxins | |
アセチルコリン加水分解 | cholinesterase inhibitors | |
筋活動電位発生 | veratridine | quinine |
tetrodotoxin | ||
筋収縮 | procaine | |
dantrolene |
.