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English Journal

Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone.

du Toit T1, Bloem LM1, Quanson JL1, Ehlers R1, Serafin AM2, Swart AC3.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2017 Feb;166:54-67. doi: 10.1016/j.jsbmb.2016.06.009. Epub 2016 Jun 21.
Adrenal C19 steroids serve as precursors to active androgens in the prostate. Androstenedione (A4), 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) are metabolised to potent androgen receptor (AR) agonists, dihydrotestosterone (DHT), 11-ketotestosterone (11KT) and 11-ketodi
PMID 27345701

Evaluation of cytotoxicity of a purified venom protein from Naja kaouthia (NKCT1) using gold nanoparticles for targeted delivery to cancer cell.

Bhowmik T1, Saha PP1, Sarkar A1, Gomes A2.
Chemico-biological interactions.Chem Biol Interact.2017 Jan 5;261:35-49. doi: 10.1016/j.cbi.2016.11.007. Epub 2016 Nov 9.
In our earlier report, gold nanoparticle (GNP) and snake venom protein toxin NKCT1 were conjugated and primary characteristics were done. In this communication, further characteristics of GNP-NKCT1 were done with TGA, BET, Zeta potential, ICP-MS, FTIR, XPS, and in vitro release kinetics for its phy
PMID 27836789

Molecular dynamics of sialic acid analogues complex with cholera toxin and DFT optimization of ethylene glycol-mediated zinc nanocluster conjugation.

Sharmila DJ1, Jino Blessy J2.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2017 Jan;35(1):182-206. doi: 10.1080/07391102.2015.1136689. Epub 2016 Jan 6.
Cholera is an infectious disease caused by cholera toxin (CT) protein of bacterium Vibrio cholerae. A sequence of sialic acid (N-acetylneuraminic acid, NeuNAc or Neu5Ac) analogues modified in its C-5 position is modelled using molecular modelling techniques and docked against the CT followed by mole
PMID 26733187