- 関
- E3 ligase、E3 ubiquitin ligase、ubiquitin-protein ligase
WordNet
- the 5th letter of the Roman alphabet (同)e
UpToDate Contents
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English Journal
- The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.
- Gilson T, Greer AE, Vindigni A, Ketner G, Hanakahi LA.SourceDepartment of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- Virology.Virology.2012 Jul 5;428(2):128-35. Epub 2012 Apr 24.
- In adenovirus E4 mutant infections, viral DNAs form concatemers through a process that requires host Non-homologous End Joining (NHEJ) proteins including DNA Ligase IV (LigIV). Adenovirus proteins E4 34k and E1b 55k form the substrate-selection component of an E3 ubiquitin ligase and prevent concate
- PMID 22534089
- Monoubiquitination-dependent chromatin loading of FancD2 in silkworms, a species lacking the FA core complex.
- Sugahara R, Mon H, Lee JM, Kusakabe T.AbstractThe Fanconi anemia (FA) pathway is required for activation and operation of the DNA interstrand cross-link (ICL) repair pathway, although the precise mechanism of the FA pathway remains largely unknown. A critical step in the FA pathway is the monoubiquitination of FANCD2 catalyzed by a FA core complex. This modification appears to allow FANCD2 to coordinate ICL repair with other DNA repair proteins on chromatin. Silkworm, Bombyx mori, lacks apparent homologues of the FA core complex. However, BmFancD2 and BmFancI, the putative substrates of the complex, and BmFancL, the putative catalytic E3 ubiquitin ligase, are conserved. Here, we report that the silkworm FancD2 is monoubiquitinated depending on FancI and FancL, and stabilized on chromatin, following MMC treatment. A substitution of BmFancD2 at lysine 519 to arginine abolishes the monoubiquitination, but not the interaction between the FancD2 and FancI. In addition, we demonstrated that depletion of BmFancD2, BmFancI or BmFancL had effects on cell proliferation in the presence of MMC. These results suggest that the FA pathway in B. mori works in the same manner as that in vertebrates.
- Gene.Gene.2012 Jun 15;501(2):180-7. Epub 2012 Apr 6.
- The Fanconi anemia (FA) pathway is required for activation and operation of the DNA interstrand cross-link (ICL) repair pathway, although the precise mechanism of the FA pathway remains largely unknown. A critical step in the FA pathway is the monoubiquitination of FANCD2 catalyzed by a FA core comp
- PMID 22513077
Japanese Journal
- E3ユビキチンリガーゼが関与する植物の細胞間隙形成
- サリドマイド催奇性の原因因子の発見から創薬への展開
- 半田 宏,伊藤 拓水,安藤 秀樹
- Organ Biology 21(2), 134-140, 2014
- … CRBN forms an E3 ubiquitin ligase complex. …
- NAID 130004715794
Related Links
- 1. Essays Biochem. 2005;41:15-30. E3 ubiquitin ligases. Ardley HC(1), Robinson PA. Author information: (1)Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds ...
- Ubiquitin modification of substrate proteins is achieved by the activity of E1 activating, E2 conjugating and E3 ligase enzymes. Substrate proteins can be modified with one (mono-ubiquitination) or many (poly-ubiquitination) molecules ...
★リンクテーブル★
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- 関
- E3 ligase、E3 ubiquitin ligase、ubiquitin ligase、ubiquitin ligase E3
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- 英
- ubiquitin ligase E3
- 関
- ユビキチン・タンパク質リガーゼ、ユビキチンリガーゼ、E3ユビキチンリガーゼ
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- 関
- E3 ubiquitin ligase、ubiquitin ligase E3、ubiquitin-protein ligase
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- 関
- E3 ligase、ubiquitin ligase E3、ubiquitin-protein ligase
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ユビキチンリガーゼ、ユビキチン連結酵素
- 関
- ubiquitin-protein ligase
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リガーゼ、連結酵素
- 関
- synthetase
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