腫瘍イニシエーター、発癌イニシエーター
- 関
- carcinogen、tumor promoter
WordNet
- any substance that produces cancer
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- 発がん物質,発がん因子
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/28 10:45:18」(JST)
[Wiki en表示]
Tumor initiation is defined as "a process in which normal cells are changed so that they are able to form tumors".[1] It is the first phase in tumor development. Mutagens, substances that cause cancer can be tumor initiators.
References
- ^ "tumor initiation". National Cancer Institute. Retrieved 9 Nov 2012.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment.
- Liu W, Phang JM.SourceMetabolism and Cancer Susceptibility Section; Basic Research Laboratory; Center for Cancer Research; Frederick National Laboratory for Cancer Research; National Institutes of Health; Frederick, MD USA.
- Autophagy.Autophagy.2012 Sep 1;8(9). [Epub ahead of print]
- Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the pathway of proline catabolism, has been identified as a mitochondrial, metabolic tumor suppressor, which is downregulated in a variety of human tumors. However, our recent findings show that PRODH/POX is upregulated by hypoxia in vi
- PMID 22885468
- Apoptosis Induction by SAHA in Cutaneous T-Cell Lymphoma Cells Is Related to Downregulation of c-FLIP and Enhanced TRAIL Signaling.
- Al-Yacoub N, Fecker LF, Möbs M, Plötz M, Braun FK, Sterry W, Eberle J.SourceDepartment of Dermatology and Allergy, Skin Cancer Center Charité (HTCC), Charité-University Medical Center Berlin, Berlin, Germany.
- The Journal of investigative dermatology.J Invest Dermatol.2012 Sep;132(9):2263-74. doi: 10.1038/jid.2012.125. Epub 2012 May 3.
- Suberoylanilide hydroxamic acid (SAHA) has been approved for the treatment of cutaneous T-cell lymphoma (CTCL), but its mode of action remained largely elusive. As shown here in four CTCL cell lines, loss of cell viability correlated with significant time- and dose-dependent induction of apoptosis,
- PMID 22551975
Japanese Journal
- Expression and Function of Apoptosis Initiator FOXO3 in Granulosa Cells During Follicular Atresia in Pig Ovaries
- MATSUDA Fuko,INOUE Naoko,MAEDA Akihisa,CHENG Yuan,SAI Takafumi,GONDA Hiroshi,GOTO Yasufumi,SAKAMAKI Kazuhiro,MANABE Noboru
- The Journal of reproduction and development 57(1), 151-158, 2011-02-01
- … In conclusion, FOXO3 is expressed in porcine ovarian follicles and induces apoptosis in granulosa cells, suggesting that it is a candidate for the initiator of follicular atresia. …
- NAID 10027901547
- Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice
- Miyamoto Shingo,Tanaka Takuji,Murakami Akira,村上 明
- Chemico-Biological Interactions 183(2), 271-275, 2010-01
- … We previously demonstrated that serum leptin levels are profoundly increased in mice which received azoxymethane (AOM) and dextran sulfate sodium (DSS) as tumor-initiator and -promoter, respectively, in a colon carcinogenesis model. …
- NAID 120001815083
Related Links
- ... the distinction between TUMOR INITIATOR AND TUMOR PROMOTER becomes problematic. The action of the initiator appears to potentiate the tumor induction process through the induction of mutations in appropriate target ...
- This finding shows that AOM is a potent strain-dependent tumor promoter in addition to being a tumor initiator. Previous studies have shown that administration of the downstream AOM metabolite is a neuroteratogenin utero (Rodier ...
Related Pictures
★リンクテーブル★
[★]
- 関
- carcinogen、tumor initiator
[★]
- 英
- tumor initiator
- 関
- がん原物質、発癌プロモーター、発癌イニシエーター
[★]
- 英
- tumor initiator
- 関
- 腫瘍イニシエーター
[★]
[★]