Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
Contu VR1, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.
Journal of neurochemistry.J Neurochem.2014 Sep;130(6):826-38. doi: 10.1111/jnc.12762. Epub 2014 Jun 18.
Parkinson's disease (PD) is a common neurodegenerative disease, but its pathogenesis remains elusive. A mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is responsible for a form of genetic PD which strongly resembles the idiopathic PD. We previously showed that 1-(3',4'-dihydroxybenzyl)-1,2,3
Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.
OBJECT: Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study
Leg swelling after inguinal sentinel lymph node biopsy and primary melanoma excision with a safety margin.
Kretschmer L1, Pratsch AL.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.J Dtsch Dermatol Ges.2012 Oct;10(10):733-9. doi: 10.1111/j.1610-0387.2012.07941.x. Epub 2012 Jun 12.
BACKGROUND: Risk-factors for leg swelling following primary melanoma excision and inguinal sentinel lymphadenectomy (SLNE) have not been sufficiently investigated.PATIENTS AND METHODS: We prospectively studied three parameters in 105 subjects: 1) subjectively perceived swelling, 2) clinically diagno
… We applied capillary electrophoresis (CE) to quantify and examine the content uniformity of ingredients of pharmaceutical formulations (diltiazem hydrochloride tablets and trimetoquinol hydrochloride tablets), and also studied separation of enantiomers through the addition of dextrin or cyclodextrin (CD) as a chiral selector. …