WordNet

a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

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1. 第1世代抗精神病剤：薬理学、投与、および副作用の比較 first generation antipsychotic medications pharmacology administration and comparative side effects
2. 寄生虫妄想症の治療 treatment of delusional parasitosis
3. 産後精神病の治療 treatment of postpartum psychosis
4. 妊娠女性における双極性障害：躁病および軽躁の治療 bipolar disorder in pregnant women treatment of mania and hypomania
5. 統合失調症に対する薬物療法：副作用マネージメント pharmacotherapy for schizophrenia side effect management

Differential effects of classical neuroleptics and a newer generation antipsychotics on the MK-801 induced behavioural primitivization in mouse.

Nilsson M1, Markinhuhta KR, Carlsson ML.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2006 May;30(3):521-30. Epub 2006 Jan 18.
Cognitive dysfunction plays an important role in mental disorders like schizophrenia and may involve inadequate glutamatergic signalling in different regions of the brain, mediated by e.g. glutamatergic N-methyl-D-aspartate (NMDA) receptors. In rodents, NMDA receptor antagonists often increase motor
PMID 16414166

The influence of oxygen-glucose deprivation on nitric oxide and intracellular Ca(2+) in cultured hippocampal neurons.

Zhang M1, Ning GM, Hong DH, Yang Y, Kutor J, Zheng XX.
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai).2003 Jun;35(6):561-6.
Nitric oxide (NO) was speculated to play an important role in the pathophysiology of cerebral ischemia. In this study, the effect of oxygen-glucose deprivation (OGD) on the cellular production of NO was investigated in cultured hippocampal neurons. Intracellular Ca(2+) was also detected as its close
PMID 12796818

Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels.

Vaca L1, Sampieri A.
The Journal of biological chemistry.J Biol Chem.2002 Nov 1;277(44):42178-87. Epub 2002 Aug 23.
In the present study we have explored the role of calmodulin (CaM) and inositol 1,4,5-trisphosphate receptor (IP(3)R) in the communication process activated after the release of calcium from the endoplasmic reticulum (ER) and the activation of calcium influx via endogenous TRP1 channels from Chinese
PMID 12196518

Influence of Diethyl Maleate-Induced Loss of Thiols on Cefmetazole Uptake into Isolated Epithelial Cells and on Cefmetazole Absorption from Ileal Loop of Rats(Pharmaceutical)

西畑利明,鈴鹿卓美,古屋淳,山崎勝,鎌田皎
Chemical & pharmaceutical bulletin 35(7), 2914-2922, 1987-07-25
… Uptake of cefmetazole into isolated rat intestinal epithelial cells increased with increasing nonprotein thiol loss induced by diethyl maleate(DEM) at concentrations up to 1 mM. … The coaddition of calmodulin inhibitors such as trifluoperazine(TFPZ) and chlorpromazine(CPZ) with 5 mM DEM restored cefmetazole uptake and inhibited protein thiol loss. …
NAID 110006281340

EFFECT OF PHENOTHIAZINES, DISODIUM ETHYLENEDIAMINE-TETRAACETIC ACID AND DIETHYL MALEATE ON IN VITRO RAT COLONIC TRANSPORT OF CEFMETAZOLE AND INULIN

SUZUKA TAKUMI,FURUYA ATSUSHI,KAMADA AKIRA,NISHIHATA TOSHIAKI
Journal of pharmacobio-dynamics 10(2), 63-71, 1987-02
… Phenothiazines as well as disodium ethylenediaminetetraacetic acid increased the transport of cefmetazole and inulin, probably via the paracellular route, while diethyl maleate increased the transport of only cefmetazole, probably via the intracellular route. …
NAID 110003636736