同: TLI

WordNet

determine the sum of; "Add all the people in this town to those of the neighboring town" (同)tot, tot up, sum, sum_up, summate, tote up, add, add together, tally, add up
damage beyond the point of repair; "My son totaled our new car"; "the rock star totals his guitar at every concert"
add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000" (同)number, add up, come, amount
the condition of being exposed to radiation
(Pavolvian conditioning) the elicitation of a conditioned response by stimulation similar but not identical to the original stimulus
(physiology) the spread of sensory neural impulses in the cortex
the apparent enlargement of a bright object when viewed against a dark background
a soft thin (usually translucent) paper (同)tissue_paper
part of an organism consisting of an aggregate of cells having a similar structure and function
a small amount (especially of a drink); "a tot of rum"
resembling lymph or lymphatic tissues

PrepTutorEJDIC

『総計の』,全体の / 『全くの』,完全な(absolute) / 『合計』,総額,総数,総量(sum) / …‘を'合計する / 合計…‘に'なる,総額が…‘に'のぼる(amount to)
照らす(照らされる)こと;発光 / (知的)啓発,開明 / 放射線治療
〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper
幼児,小児 / (特に酒類の)少量,一杯,一口
…‘を'合計する《+up+名,+名+up》 / 合計(…に)なる《+up to+名》
リンパ状(液)の

UpToDate Contents

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1. 急性心臓同種移植拒絶反応：治療 acute cardiac allograft rejection treatment
2. 成人における進行性多発性硬化症の治療 treatment of progressive multiple sclerosis in adults
3. 限局期（I/II）濾胞性リンパ腫の初期治療 initial treatment of limited stage i ii follicular lymphoma
4. 慢性肺移植拒絶反応：閉塞性細気管支炎 chronic lung transplant rejection bronchiolitis obliterans
5. 古典型ホジキンリンパ腫の治療後の二次癌 second malignancies after treatment of classical hodgkin lymphoma

English Journal

Immune cell reconstitution after exposure to potentially lethal doses of radiation in the nonhuman primate.

MacVittie TJ, Bennett AW, V Cohen M, Farese AM, Higgins A, Hankey KG.Author information *University of Maryland, School of Medicine, Dept. of Radiation Oncology, Baltimore, MD; †Integrated Research Facility, Frederick, MD; ‡Naval Medical Research Center, Silver Spring, MD.AbstractDelayed immune reconstitution remains a major cause of morbidity associated with myelosuppression induced by cytotoxic therapy or myeloablative conditioning for stem cell transplant, as well as potentially lethal doses of total- or partial-body irradiation. Restoration of a functional immune cell repertoire requires hematopoietic stem cell reconstitution for all immune cells and effective thymopoiesis for T cell recovery. There are no medical countermeasures available to mitigate damage consequent to high-dose, potentially lethal irradiation, and there are no well characterized large animal models of prolonged immunosuppression to assess efficacy of potential countermeasures. Herein, the authors describe a model of T and B cell reconstitution following lethal doses of partial-body irradiation with 5% bone marrow sparing that includes full exposure of the thymus. Rhesus macaques (n = 31 male, 5.5-11.3 kg body weight) were exposed to midline tissue doses of 9.0-12.0 Gy using 6 MV LINAC-derived photons at a dose rate of 0.80 Gy min, sparing approximately 5% of bone marrow (tibiae, ankles, and feet). All animals received medical management and were monitored for myeloid and lymphoid suppression and recovery through 180 d post-exposure. Myeloid recovery was assessed by neutrophil and platelet-related hematological parameters. Reconstitution of B and T cell subsets was assessed by flow cytometric immunophenotyping, and recent thymic emigrants were identified by RT-PCR of T cell receptor excision circles. Mortality was recorded through 180 d post-exposure. Acute myelo-suppression was characterized by severe neutropenia and thrombocytopenia, followed by recovery 30-60 d post-exposure. Total T (CD3+) and B (CD20+) cells were reduced significantly following exposure and exhibited differential recovery patterns post-exposure. Both CD4+ and CD8+ subsets of naïve T cells and total CD4+ T cell counts remained significantly lower than baseline through 180 d post-exposure. The failure of recent thymic emigrants and naïve T cell subsets to recover to normal baseline values reflects the severe radiation effects on the recovery of marrow-derived stem and early thymic progenitor cells, their mobilization and seeding of receptive thymic niches, and slow endogenous thymic regeneration.
Health physics.Health Phys.2014 Jan;106(1):84-96. doi: 10.1097/HP.0b013e3182a2a9b2.
Delayed immune reconstitution remains a major cause of morbidity associated with myelosuppression induced by cytotoxic therapy or myeloablative conditioning for stem cell transplant, as well as potentially lethal doses of total- or partial-body irradiation. Restoration of a functional immune cell re
PMID 24276552

Clinical and pathologic risk factors of tumor recurrence in patients with node-negative early breast cancer after mastectomy.

Lin PH, Yeh MH, Liu LC, Chen CJ, Tsui YC, Su CH, Wang HC, Liang JA, Chang HW, Wu HS, Yeh SP, Li LY, Chiu CF.Author information Graduate Institute of Clinical Medicine Science, China Medical University, Taichung, Taiwan; Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.AbstractBACKGROUND AND OBJECTIVES: Patients with node-negative breast cancer (NNBC) usually have a good prognosis, but tumor recurrence still compromises survival. In this study, we sought to identify clinical and pathologic factors that predict recurrence.
Journal of surgical oncology.J Surg Oncol.2013 Nov;108(6):352-7. doi: 10.1002/jso.23403. Epub 2013 Aug 31.
BACKGROUND AND OBJECTIVES: Patients with node-negative breast cancer (NNBC) usually have a good prognosis, but tumor recurrence still compromises survival. In this study, we sought to identify clinical and pathologic factors that predict recurrence.METHODS: A total of 716 patients who were proved wi
PMID 23996583

Surgery for esophageal cancer: goals of resection and optimizing outcomes.

Rizk N.Author information Department of Surgery, Thoracic Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, C 883, New York, NY 10065, USA. Electronic address: rizkn@mskcc.org.AbstractDetermining what defines an adequate esophageal resection to optimize long-term outcomes in esophageal cancer is an elusive goal. The primary reason for this ambiguousness is the almost total lack of good quality prospective randomized surgical trials that examine this question adequately. Most available data are derived from small retrospective series typically representing single institution series and their treatment biases. The intent of this article is to identify the goals of an appropriate esophagectomy for cancer, essentially defining the targets that should be achieved from an operation.
Thoracic surgery clinics.Thorac Surg Clin.2013 Nov;23(4):491-8. doi: 10.1016/j.thorsurg.2013.07.009. Epub 2013 Oct 13.
Determining what defines an adequate esophageal resection to optimize long-term outcomes in esophageal cancer is an elusive goal. The primary reason for this ambiguousness is the almost total lack of good quality prospective randomized surgical trials that examine this question adequately. Most avai
PMID 24199699

Japanese Journal

Effect of Low-Level Laser Irradiation on CXCL13 Gene Expression in Rheumatoid Arthritis Rat Joints

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Journal of Hard Tissue
… Low-level laser irradiation (LLLI) is currently being evaluated for the treatment of RA, but the molecular mechanism underlying the effectiveness of LLLI in RA is unclear. … B-cell-attracting chemokine-1 (CXCL13) is classified as a lymphoid chemokine and is a potent B-cell chemoattractant, leading to the local production of the autoantibody. …
NAID 130004480504

放射線療法と rituximab 単剤療法が奏効した膀胱原発 mucosa-associated lymphoid tissue(MALT)リンパ腫

寺崎靖,奥村廣和,石浦嘉久 [他],余川茂,栗林正人,児玉浩一,元井勇,杉原政美,齋藤勝彦,田中健大,吉野正,大竹茂樹,中尾眞二
臨床血液 = The Japanese Journal of Clinical Hematology 49(1), 30-34, 2008-01-30
症例は64歳，女性。2005年12月に全身倦怠を主訴に当院受診。Hb 9.0 g/dlと貧血を認めた。上部消化管内視鏡検査では出血性胃潰瘍を認め，これが貧血の原因と考えられた。また，腹部超音波検査では，両水腎症・水尿管症を認めた。膿尿と顕微鏡的血尿を認め，尿培養でEscherichia coliを108 CFU/ml検出した。骨盤部MRIを施行したところ，膀胱後壁から三角部にかけて壁肥厚を認めたた …
NAID 10021256919

頬部皮下に発生したMALTリンパ腫例

工藤香児,藤吉達也,坂部亜希子 [他],鈴木秀明,藤村武之,溝部貴光
耳鼻咽喉科臨床 97(8), 707-711, 2004-08-01
… MALT lymphoma is characterized as a type of low-grade extranodal B cell lymphoma arising from mucosa-associated lymphoid tissue (MALT). … Total resection of the tumor was performed. … A complete remission was obtained with 4 courses of Rituximab (anti-CD20 monoclonal antibody) therapy and irradiation at 40Gy. …
NAID 10013353678

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