甲状腺ホルモン受容体β
- 関
- TR beta、TRbeta
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
- suggestive of a thyroid disorder; "thyroid personality"
- of or relating to the thyroid gland; "thyroid deficiency"; "thyroidal uptake" (同)thyroidal
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
- 甲状腺 / 甲状腺の
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/17 05:35:18」(JST)
[Wiki en表示]
| THRB |
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| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
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1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1
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| Identifiers |
| Aliases |
THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta |
| External IDs |
MGI: 98743 HomoloGene: 36025 GeneCards: THRB |
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| Targeted by Drug |
| DL-3,3',5'-triiodothyronine, tiratricol, liothyronine, levothyroxine[1] |
| Gene ontology |
| Molecular function |
• sequence-specific DNA binding
• transcription corepressor activity
• zinc ion binding
• metal ion binding
• steroid hormone receptor activity
• protein binding
• enzyme binding
• chromatin DNA binding
• thyroid hormone binding
• transcription factor activity, sequence-specific DNA binding
• DNA binding
• thyroid hormone receptor activity
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| Cellular component |
• nucleoplasm
• nuclear chromatin
• extracellular exosome
• nucleus
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| Biological process |
• regulation of transcription, DNA-templated
• regulation of heart contraction
• female courtship behavior
• regulation of transcription from RNA polymerase II promoter
• negative regulation of transcription from RNA polymerase II promoter
• sensory perception of sound
• Type I pneumocyte differentiation
• negative regulation of female receptivity
• animal organ morphogenesis
• transcription initiation from RNA polymerase II promoter
• negative regulation of transcription, DNA-templated
• positive regulation of transcription from RNA polymerase II promoter
• steroid hormone mediated signaling pathway
• intracellular receptor signaling pathway
• transcription, DNA-templated
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| Sources:Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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NM_000461
NM_001128176
NM_001128177
NM_001252634
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| RefSeq (protein) |
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NP_000452.2
NP_001121648.1
NP_001121649.1
NP_001239563.1
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NP_001106888.1
NP_033406.1
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| Location (UCSC) |
Chr 3: 24.12 – 24.5 Mb |
Chr 14: 17.66 – 18.04 Mb |
| PubMed search |
[2] |
[3] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.[4][5]
Contents
- 1 Function
- 2 Interactions
- 3 References
- 4 Further reading
Function
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far.[6]
Interactions
Thyroid hormone receptor beta has been shown to interact with:
- BRD8,[7]
- CCND1,[8]
- NCOA1,[9][10]
- NCOA6,[11][12][13][14]
- NCOR2,[9][15][16]
- NR2F6,[17]
- PPARGC1A,[18] and
- RXRA.[7][10]
References
- ^ "Drugs that physically interact with Thyroid hormone receptor beta view/edit references on wikidata".
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)".
- ^ Sakurai A, Nakai A, DeGroot LJ (June 1990). "Structural analysis of human thyroid hormone receptor beta gene". Mol. Cell. Endocrinol. 71 (2): 83–91. doi:10.1016/0303-7207(90)90245-4. PMID 1973914.
- ^ "Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)".
- ^ a b Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J. Biol. Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
- ^ Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. doi:10.1074/jbc.M203380200. PMID 12048199.
- ^ a b Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. doi:10.1210/endo.139.10.6218. PMID 9751500.
- ^ a b Jeyakumar M, Tanen MR, Bagchi MK (June 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Mol. Endocrinol. 11 (6): 755–67. doi:10.1210/mend.11.6.0003. PMID 9171239.
- ^ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331.
- ^ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
- ^ Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
- ^ Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/mend.16.1.0755. PMID 11773444.
- ^ Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542.
- ^ Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM (September 2001). "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance". Mol. Endocrinol. 15 (9): 1529–38. doi:10.1210/me.15.9.1529. PMID 11518802.
- ^ Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
- ^ Wu Y, Delerive P, Chin WW, Burris TP (March 2002). "Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1". J. Biol. Chem. 277 (11): 8898–905. doi:10.1074/jbc.M110761200. PMID 11751919.
Further reading
- Lazar MA, Chin WW (1990). "Nuclear thyroid hormone receptors". J. Clin. Invest. 86 (6): 1777–82. doi:10.1172/JCI114906. PMC 329808. PMID 2254444.
- Forrest D, Reh TA, Rüsch A (2002). "Neurodevelopmental control by thyroid hormone receptors". Curr. Opin. Neurobiol. 12 (1): 49–56. doi:10.1016/S0959-4388(02)00289-1. PMID 11861164.
- González-Sancho JM, García V, Bonilla F, Muñoz A (2003). "Thyroid hormone receptors/THR genes in human cancer". Cancer Lett. 192 (2): 121–32. doi:10.1016/S0304-3835(02)00614-6. PMID 12668276.
- Cugini CD, Leidy JW, Chertow BS, Bérard J, Bradley WE, Menke JB, Hao EH, Usala SJ (1992). "An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity". J. Clin. Endocrinol. Metab. 74 (5): 1164–70. doi:10.1210/jc.74.5.1164. PMID 1314846.
- Behr M, Loos U (1992). "A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA beta thyroid hormone receptor gene in a family with generalized thyroid hormone resistance". Mol. Endocrinol. 6 (7): 1119–26. doi:10.1210/me.6.7.1119. PMID 1324420.
- Falcone M, Miyamoto T, Fierro-Renoy F, Macchia E, DeGroot LJ (1992). "Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform". Endocrinology. 131 (5): 2419–29. doi:10.1210/en.131.5.2419. PMID 1425440.
- Schmidt ED, Schmidt ED, van der Gaag R, Ganpat R, Broersma L, de Boer PA, Moorman AF, Lamers WH, Wiersinga WM, Koornneef L (1992). "Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles". J. Endocrinol. 133 (1): 67–74. doi:10.1677/joe.0.1330067. PMID 1517709.
- Adams M, Nagaya T, Tone Y, Jameson JL, Chatterjee VK (1992). "Functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome". Clin. Endocrinol. (Oxf). 36 (3): 281–9. doi:10.1111/j.1365-2265.1992.tb01444.x. PMID 1563081.
- Sasaki S, Nakamura H, Tagami T, Miyoshi Y, Tanaka K, Imura H (1992). "A point mutation of the T3 receptor beta 1 gene in a kindred of generalized resistance to thyroid hormone". Mol. Cell. Endocrinol. 84 (3): 159–66. doi:10.1016/0303-7207(92)90026-3. PMID 1587388.
- Nagaya T, Madison LD, Jameson JL (1992). "Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes". J. Biol. Chem. 267 (18): 13014–9. PMID 1618799.
- Shuto Y, Wakabayashi I, Amuro N, Minami S, Okazaki T (1992). "A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-beta associated with a family with generalized resistance to thyroid hormone". J. Clin. Endocrinol. Metab. 75 (1): 213–7. doi:10.1210/jc.75.1.213. PMID 1619012.
- Näär AM, Boutin JM, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG (1991). "The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors". Cell. 65 (7): 1267–79. doi:10.1016/0092-8674(91)90021-P. PMID 1648451.
- Usala SJ, Menke JB, Watson TL, Wondisford FE, Weintraub BD, Bérard J, Bradley WE, Ono S, Mueller OT, Bercu BB (1991). "A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor". Mol. Endocrinol. 5 (3): 327–35. doi:10.1210/mend-5-3-327. PMID 1653889.
- Bodenner DL, Mroczynski MA, Weintraub BD, Radovick S, Wondisford FE (1991). "A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene". J. Biol. Chem. 266 (32): 21666–73. PMID 1657975.
- Parrilla R, Mixson AJ, McPherson JA, McClaskey JH, Weintraub BD (1991). "Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain". J. Clin. Invest. 88 (6): 2123–30. doi:10.1172/JCI115542. PMC 295818. PMID 1661299.
- Usala SJ, Menke JB, Watson TL, Bérard WE, Bradley C, Bale AE, Lash RW, Weintraub BD (1991). "A new point mutation in the 3,5,3'-triiodothyronine-binding domain of the c-erbA beta thyroid hormone receptor is tightly linked to generalized thyroid hormone resistance". J. Clin. Endocrinol. Metab. 72 (1): 32–8. doi:10.1210/jcem-72-1-32. PMID 1846005.
- Usala SJ, Tennyson GE, Bale AE, Lash RW, Gesundheit N, Wondisford FE, Accili D, Hauser P, Weintraub BD (1990). "A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds". J. Clin. Invest. 85 (1): 93–100. doi:10.1172/JCI114438. PMC 296391. PMID 2153155.
- Sakurai A, Takeda K, Ain K, Ceccarelli P, Nakai A, Seino S, Bell GI, Refetoff S, DeGroot LJ (1989). "Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8977–81. doi:10.1073/pnas.86.22.8977. PMC 298414. PMID 2510172.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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PDB gallery
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1bsx: STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS
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1n46: CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC
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1nax: Thyroid receptor beta1 in complex with a beta-selective ligand
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1nq0: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
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1nq1: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
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1nq2: Two RTH Mutants with Impaired Hormone Binding
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1nuo: Two RTH Mutants with Impaired Hormone Binding
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1q4x: Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24
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1r6g: Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound
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1xzx: Thyroxine-Thyroid Hormone Receptor Interactions
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1y0x: Thyroxine-Thyroid Hormone Receptor Interactions
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2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
- Decherf S, Seugnet I, Becker N, Demeneix BA, Clerget-Froidevaux MS.SourceCNRS UMR 7221-USM 501, «Evolution of Endocrine Regulations», «Regulations, Development and Molecular Diversity» Department, Muséum National d'Histoire Naturelle, 57 rue Cuvier, CP 32, 75231 Paris Cedex 5, France.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Dec 5;381(1-2):115-23. doi: 10.1016/j.mce.2013.07.016. Epub 2013 Jul 26.
- How Retinoid X receptors (RXR) and thyroid hormone receptors (TR) interact on negative TREs and whether RXR subtype specificity is determinant in such regulations is unknown. In a set of functional studies, we analyzed RXR subtype effects in T3-dependent repression of hypothalamic thyrotropin-releas
- PMID 23896434
- How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering.
- Ratman D, Vanden Berghe W, Dejager L, Libert C, Tavernier J, Beck IM, De Bosscher K.SourceCytokine Receptor Lab, VIB Department of Medical Protein Research, VIB, UGent, Albert Baertsoenkaai 3, B-9000 Gent, Belgium. Electronic address: Dariusz.Ratman@vib-ugent.be.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Nov 5;380(1-2):41-54. doi: 10.1016/j.mce.2012.12.014. Epub 2012 Dec 23.
- The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response el
- PMID 23267834
- Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.
- Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM.SourceGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Nov 4. [Epub ahead of print]
- Molecular targeting of the two receptor interaction domains of the epigenetic repressor silencing mediator of retinoid and thyroid hormone receptors (SMRTmRID) produced a transplantable skeletal syndrome that reduced radial bone growth, increased numbers of bone-resorbing periosteal osteoclasts, and
- PMID 24191050
Japanese Journal
- MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes.
- Nishi Hitoo,Ono Koh,Horie Takahiro,Nagao Kazuya,Kinoshita Minako,Kuwabara Yasuhide,Watanabe Shin,Takaya Tomohide,Tamaki Yodo,Takanabe-Mori Rieko,Wada Hiromichi,Hasegawa Koji,Iwanaga Yoshitaka,Kawamura Teruhisa,Kita Toru,Kimura Takeshi
- Molecular and cellular biology 31(4), 744-755, 2011-02
- … Through a bioinformatics screening using TargetScan, we identified thyroid hormone receptor β1 (TRβ1), which negatively regulates β-MHC transcription, as a target of miR-27a. … Moreover, miR-27a was demonstrated to modulate β-MHC gene regulation via thyroid hormone signaling and to be upregulated during the differentiation of mouse embryonic stem (ES) cells or in hypertrophic hearts in association with β-MHC gene upregulation. …
- NAID 120002871162
- A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity
- MATSUSE Michiko,SAENKO Vladimir,SEDLIAROU Ilya,ROGOUNOVITCH Tatiana,NAKAZAWA Yuka,MITSUTAKE Norisato,AKULEVICH Natallia,NAMBA Hiroyuki,YAMASHITA Shunichi
- Journal of radiation research 49(1), 17-27, 2008-01-15
- … 長崎大学学位論文 学位記番号:博（医歯薬）甲第148号 博士（医学）学位授与年月日:平成20年3月19日Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. …
- NAID 110006570524
Related Links
- thyroid hormone receptor beta A protein encoded by THRB on chromosome 3p24.2, which is a nuclear hormone receptor for triiodothyronine and one of several thyroid ... Disclaimer All content on this website, including dictionary ...
- The official name of this gene is “thyroid hormone receptor, beta.” THRB is the gene's official symbol. The THRB gene is also known by other names, listed below. Read more about gene names and symbols on the About page.
★リンクテーブル★
[★]
- 関
- thyroid hormone receptor beta
[★]
- 英
- thyroid hormone receptor beta、TRbeta
[★]
- 関
- thyroid gland、thyroidal
[★]
[★]
β、ベータ
[★]