甲状腺ホルモン受容体α
- 関
- TRalpha
WordNet
- first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
- the 1st letter of the Greek alphabet
- the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
- early testing stage of a software or hardware product; "alpha version"
- suggestive of a thyroid disorder; "thyroid personality"
- of or relating to the thyroid gland; "thyroid deficiency"; "thyroidal uptake" (同)thyroidal
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
- any high mountain
PrepTutorEJDIC
- アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
- 甲状腺 / 甲状腺の
- =sense organ / 受信装置
- ホルモン
- 高山,高峰
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/23 19:17:30」(JST)
[Wiki en表示]
| THRA |
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| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
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1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX
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| Identifiers |
| Aliases |
THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha |
| External IDs |
MGI: 98742 HomoloGene: 37747 GeneCards: THRA |
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| Targeted by Drug |
| DL-3,3',5'-triiodothyronine, tiratricol, liothyronine, levothyroxine[1] |
| Gene ontology |
| Molecular function |
• protein complex binding
• transcription regulatory region sequence-specific DNA binding
• protein binding
• single-stranded RNA binding
• zinc ion binding
• chromatin DNA binding
• RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
• steroid receptor RNA activator RNA binding
• transcription factor binding
• TBP-class protein binding
• steroid hormone receptor activity
• DNA binding
• protein domain specific binding
• sequence-specific DNA binding
• metal ion binding
• transcription regulatory region DNA binding
• transcription factor activity, sequence-specific DNA binding
• thyroid hormone receptor activity
• thyroid hormone binding
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| Cellular component |
• cytoplasm
• nucleoplasm
• nucleus
• cytosol
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| Biological process |
• regulation of transcription from RNA polymerase II promoter
• response to cold
• cytoplasmic sequestering of transcription factor
• hormone-mediated signaling pathway
• regulation of thyroid hormone mediated signaling pathway
• thyroid gland development
• regulation of transcription, DNA-templated
• ossification
• female courtship behavior
• cartilage condensation
• negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
• Type I pneumocyte differentiation
• transcription, DNA-templated
• steroid hormone mediated signaling pathway
• transcription from RNA polymerase II promoter
• regulation of lipid catabolic process
• regulation of heart contraction
• animal organ morphogenesis
• positive regulation of female receptivity
• learning or memory
• regulation of myeloid cell apoptotic process
• positive regulation of transcription from RNA polymerase II promoter
• transcription initiation from RNA polymerase II promoter
• erythrocyte differentiation
• negative regulation of DNA-templated transcription, initiation
• positive regulation of myotube differentiation
• negative regulation of transcription, DNA-templated
• intracellular receptor signaling pathway
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| Sources:Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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NM_199334
NM_001190918
NM_001190919
NM_003250
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| RefSeq (protein) |
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NP_001177847
NP_001177848
NP_003241
NP_955366
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NP_001300912.1
NP_835161.1
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| Location (UCSC) |
Chr 17: 40.06 – 40.09 Mb |
Chr 11: 98.74 – 98.77 Mb |
| PubMed search |
[2] |
[3] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.[4][5][6]
Contents
- 1 Function
- 2 Interactions
- 3 References
- 4 Further reading
Function
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[4]
Interactions
THR1 has been shown to interact with:
- COPS2,[7]
- EP300,[8]
- ITGB3BP,[9][10]
- MED1,[11]
- MED6,[12]
- MED12,[12]
- MED16,[12]
- MEF2A,[8]
- NCOA6,[13][14]
- TRIP11,[15] and
- UBC.[16]
References
- ^ "Drugs that physically interact with Thyroid hormone receptor, alpha view/edit references on wikidata".
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ a b "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)".
- ^ Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B (Jan 1984). "Chromosomal localisation of the human homologues to the oncogenes erbA and B". The EMBO Journal. 3 (1): 159–63. PMC 557313. PMID 6323162.
- ^ Dayton AI, Selden JR, Laws G, Dorney DJ, Finan J, Tripputi P, Emanuel BS, Rovera G, Nowell PC, Croce CM (Jul 1984). "A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America. 81 (14): 4495–9. doi:10.1073/pnas.81.14.4495. PMC 345617. PMID 6589608.
- ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
- ^ a b De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G (Feb 2003). "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". The Biochemical Journal. 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. PMC 1223100. PMID 12371907.
- ^ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Molecular and Cellular Biology. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.
- ^ Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (Oct 1999). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Molecular and Cellular Biology. 19 (10): 7191–202. doi:10.1128/mcb.19.10.7191. PMC 84712. PMID 10490654.
- ^ Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (Jul 1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 7939–44. doi:10.1073/pnas.95.14.7939. PMC 20908. PMID 9653119.
- ^ a b c Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
- ^ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (Nov 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". The Journal of Biological Chemistry. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
- ^ Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (Jun 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular Endocrinology. 14 (6): 915–25. doi:10.1210/mend.14.6.0471. PMID 10847592.
- ^ Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.
- ^ Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X (Jul 2008). "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells". Proteomics. 8 (14): 2885–96. doi:10.1002/pmic.200700887. PMID 18655026.
Further reading
- Forrest D, Reh TA, Rüsch A (Feb 2002). "Neurodevelopmental control by thyroid hormone receptors". Current Opinion in Neurobiology. 12 (1): 49–56. doi:10.1016/S0959-4388(02)00289-1. PMID 11861164.
- Sakurai A, Bell GI, DeGroot LJ (Oct 1992). "Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA1) on chromosome 17". Human Molecular Genetics. 1 (7): 553. doi:10.1093/hmg/1.7.553-a. PMID 1307263.
- Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
- Schmidt ED, Schmidt ED, van der Gaag R, Ganpat R, Broersma L, de Boer PA, Moorman AF, Lamers WH, Wiersinga WM, Koornneef L (Apr 1992). "Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles". The Journal of Endocrinology. 133 (1): 67–74. doi:10.1677/joe.0.1330067. PMID 1517709.
- Yen PM, Sunday ME, Darling DS, Chin WW (Mar 1992). "Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries". Endocrinology. 130 (3): 1539–46. doi:10.1210/en.130.3.1539. PMID 1537303.
- Laudet V, Begue A, Henry-Duthoit C, Joubel A, Martin P, Stehelin D, Saule S (Mar 1991). "Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene". Nucleic Acids Research. 19 (5): 1105–12. doi:10.1093/nar/19.5.1105. PMC 333788. PMID 1850510.
- Nakai A, Sakurai A, Bell GI, DeGroot LJ (Nov 1988). "Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues". Molecular Endocrinology. 2 (11): 1087–92. doi:10.1210/mend-2-11-1087. PMID 2464749.
- Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, Yamamoto T (Apr 1989). "Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus". Cell. 57 (1): 31–9. doi:10.1016/0092-8674(89)90169-4. PMID 2539258.
- Sakurai A, Nakai A, DeGroot LJ (Feb 1989). "Expression of three forms of thyroid hormone receptor in human tissues". Molecular Endocrinology. 3 (2): 392–9. doi:10.1210/mend-3-2-392. PMID 2710139.
- Sap J, Muñoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennström B (1987). "The c-erb-A protein is a high-affinity receptor for thyroid hormone". Nature. 324 (6098): 635–40. doi:10.1038/324635a0. PMID 2879242.
- Nakai A, Seino S, Sakurai A, Szilak I, Bell GI, DeGroot LJ (Apr 1988). "Characterization of a thyroid hormone receptor expressed in human kidney and other tissues". Proceedings of the National Academy of Sciences of the United States of America. 85 (8): 2781–5. doi:10.1073/pnas.85.8.2781. PMC 280083. PMID 3357890.
- Mitelman F, Manolov G, Manolova Y, Billström R, Heim S, Kristoffersson U, Mandahl N, Ferro MT, San Roman C (Jun 1986). "High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2". Cancer Genetics and Cytogenetics. 22 (2): 95–8. doi:10.1016/0165-4608(86)90168-8. PMID 3458521.
- Benbrook D, Pfahl M (Nov 1987). "A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library". Science. 238 (4828): 788–91. doi:10.1126/science.3672126. PMID 3672126.
- Pfahl M, Benbrook D (Nov 1987). "Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor". Nucleic Acids Research. 15 (22): 9613. doi:10.1093/nar/15.22.9613. PMC 306505. PMID 3684612.
- Chen JD, Evans RM (Oct 1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
- Desai-Yajnik V, Hadzic E, Modlinger P, Malhotra S, Gechlik G, Samuels HH (Aug 1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator". Journal of Virology. 69 (8): 5103–12. PMC 189328. PMID 7609079.
- Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
- Desai-Yajnik V, Samuels HH (1994). "Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat". Transactions of the Association of American Physicians. 106: 13–32. PMID 8036737.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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PDB gallery
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1nav: Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1
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2h77: Crystal structure of human TR alpha bound T3 in monoclinic space group
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2h79: Crystal Structure of human TR alpha bound T3 in orthorhombic space group
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UpToDate Contents
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English Journal
- Impact of estrogen and progesterone receptor expression on the clinical and molecular features of papillary thyroid cancer.
- Vannucchi G1, De Leo S2, Perrino M2, Rossi S2, Tosi D2, Cirello V2, Colombo C2, Bulfamante G3, Vicentini L2, Fugazzola L3.
- European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2015 Jul;173(1):29-36. doi: 10.1530/EJE-15-0054. Epub 2015 Apr 10.
- BACKGROUND: Thyroid cancer is highly prevalent in women during the fertile age, which suggests a possible impact of hormonal and reproductive factors.METHODS: We studied the expression of estrogen receptor α (ERα or ESR1) and progesterone receptor (PR or PGR) in 182 female and male patients with p
- PMID 25862786
- Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity.
- Merrill SJ1, Mu Y2.
- Journal of theoretical biology.J Theor Biol.2015 Jun 21;375:95-100. doi: 10.1016/j.jtbi.2014.12.015. Epub 2015 Jan 6.
- Autoimmune thyroid diseases (AITDs), predominately Graves׳ disease and Hashimoto׳s thyroiditis, comprise the most common autoimmune diseases in humans. Both have the production of anti-thyroid antibody as an important aspect and both are much more prevalent in females, being at least 10 times more
- PMID 25576242
- Thyroid Hormone-Otx2 Signaling Is Required for Embryonic Ventral Midbrain Neural Stem Cells Differentiated into Dopamine Neurons.
- Chen C1, Ma Q1, Chen X2, Zhong M1, Deng P1, Zhu G1, Zhang Y1, Zhang L1, Yang Z2, Zhang K2, Guo L3, Wang L4, Yu Z1, Zhou Z1.
- Stem cells and development.Stem Cells Dev.2015 Jun 17. [Epub ahead of print]
- Midbrain dopamine (DA) neurons are essential for maintaining multiple brain functions. These neurons have also been implicated in relation with diverse neurological disorders. However, how these neurons are developed from neuronal stem cells (NSCs) remains largely unknown. In this study, we provide
- PMID 25867707
Japanese Journal
- Interactions of Thyroid Hormone Receptor with Ku Proteins and Interleukin Enhancer Binding Factor 3 Modulate the Promoter Activity of Thyroid-Stimulating Hormone Alpha
- The Vitamin D3 1alpha-Hydroxylase Gene and Its Regulation by Active Vitamin D3
- Bioscience, biotechnology, and biochemistry 75(2), 208-213, 2011-02-23
- NAID 10027897347
- Proteomic Analysis of Importin .ALPHA.-interacting Proteins in Adult Mouse Brain
Related Links
- The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone.
- 190120 - THYROID HORMONE RECEPTOR, ALPHA-1; THRA - THYROID HORMONE RECEPTOR, CENTRAL NERVOUS SYSTEM FORM; THRA1;; ERBA-ALPHA;; ONCOGENE ERBA; ERBA;; ERBA-RELATED 7 ...
★リンクテーブル★
[★]
- 関
- thyroid hormone receptor alpha
[★]
- 英
- thyroid hormone receptor alpha、TRalpha
[★]
- 関
- thyroid gland、thyroidal
[★]
α、アルファ
- 関
- alfa
[★]