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Delivery of calf thymus DNA to tumor by folate receptor targeted cationic liposomes.

Li H, Piao L, Yu B, Yung BC, Zhang W, Wang PG, Lee JL, Lee RJ.SourceDivision of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Biomaterials.Biomaterials.2011 Sep;32(27):6614-20. Epub 2011 Jun 12.
Calf thymus DNA (ctDNA) has been shown to stimulate macrophages to produce cytokines both in?vitro and in?vivo when complexed with cationic liposomes. In addition, direct cytotoxicity of ctDNA has been found in tissue culture and in mice. In this study, ctDNA and folate receptor targeted cationic
PMID 21665267

Mouse thymic epithelial cell lines expressing "Aire" and peripheral tissue-specific antigens reproduce in vitro negative selection of T cells.

Yamaguchi Y, Takayanagi A, Chen J, Sakai K, Kudoh J, Shimizu N.SourceAdvanced Research Center for Genome Super Power, Keio University, 2 Okubo, Tsukuba, Ibaraki 300-2611, Japan.
Experimental cell research.Exp Cell Res.2011 Aug 15;317(14):2019-30. Epub 2011 Jun 15.
In the human thymus, AIRE (autoimmune regulator) gene is expressed in a very limited type of medullary thymic epithelial cells (mTECs) and no cognate cell lines are available, hence the molecular analysis of AIRE gene function has been difficult. To improve this situation, we attempted to isolate Ai
PMID 21683072

藤澤琢郎,湯川尚哉,井上俊哉,永田基樹,小椋学,八木正夫,宮本真,竹村博一,鈴木健介,友田幸一
頭頸部外科 21(1), 69-72, 2011
… 術後の永久病理診断では，胸腺癌とCarcinoma showing thymus like differentation（CASTLE）両方の可能性があったが，腫瘍と甲状腺の境界が明瞭であることから胸腺癌と診断された。 …
NAID 130000815949

伴秀利,西村嘉裕
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 24(7), 1092-1097, 2010-11-15
症例は60歳女性．検診で胸部異常陰影を指摘された．胸部CTおよびFDG-PETを施行され，胸腺腫を疑われて紹介受診した．前医の胸部CTおよび術前に施行した胸部MRIにおける限局性非浸潤性所見と，FDG-PETにおいてSUVmax 3.4とごく軽度の集積率増加であったことから，正岡分類I期の非浸潤性胸腺腫と術前診断し手術を行った．術後病理組織検査によって胸腺原発のLow-gradeのmucoepid …
NAID 10026963800