WordNet
- relating to or involved in therapy; "therapeutic approach to criminality" (同)therapeutical
- branch of medicine concerned with the treatment of disease
- the formation of new blood vessels
PrepTutorEJDIC
- 治療[上]の
- 治療学
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 21:23:34」(JST)
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- 1. 難治性狭心症マネージメントのための血管新生療法 therapeutic angiogenesis for management of refractory angina
- 2. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease
- 3. 下肢の慢性重症下肢虚血の治療 treatment of chronic lower extremity critical limb ischemia
- 4. 血栓性閉塞性血管炎（バージャー病） thromboangiitis obliterans buergers disease
- 5. 跛行のマネージメント management of claudication
English Journal
- Unraveling galectin-1 as a novel therapeutic target for cancer.
- Astorgues-Xerri L, Riveiro ME, Tijeras-Raballand A, Serova M, Neuzillet C, Albert S, Raymond E, Faivre S.Author information Oncology Therapeutic Development, 100 rue Martre, 92110 Clichy, France. Electronic address: lucile.astxer@wanadoo.fr.AbstractGalectins belong to a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues and displays a wide range of biological activities. In oncology, galectin-1 plays a pivotal role in tumor growth and in the multistep process of invasion, angiogenesis, and metastasis. Evidence indicates that galectin-1 exerts a variety of functions at different steps of tumor progression. Moreover, it has been demonstrated that galectin-1 cellular localization and galectin-1 binding partners depend on tumor localization and stage. Recently, galectin-1 overexpression has been extensively documented in several tumor types and/or in the stroma of cancer cells. Its expression is thought to reflect tumor aggressiveness in several tumor types. Galectin-1 has been identified as a promising drug target using synthetic and natural inhibitors. Preclinical data suggest that galectin-1 inhibition may lead to direct antiproliferative effects in cancer cells as well as antiangiogenic effects in tumors. We provide an up-to-date overview of available data on the role of galectin-1 in different molecular and biochemical pathways involved in human malignancies. One of the major challenges faced in targeting galectin-1 is the translation of current knowledge into the design and development of effective galectin-1 inhibitors in cancer therapy.
- Cancer treatment reviews.Cancer Treat Rev.2014 Mar;40(2):307-19. doi: 10.1016/j.ctrv.2013.07.007. Epub 2013 Aug 1.
- Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues and displays a wide range of biological activities. In oncology, galectin-1 plays a pivotal role in tumor growth and in
- PMID 23953240
- Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma.
- Bell D, Hanna EY, Miele L, Roberts D, Weber RS, El-Naggar AK.Author information Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: diana.bell@mdanderson.org.AbstractNotch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.
- Annals of diagnostic pathology.Ann Diagn Pathol.2014 Feb;18(1):10-3. doi: 10.1016/j.anndiagpath.2013.10.001. Epub 2013 Oct 10.
- Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC
- PMID 24238845
- The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer.
- Berchtold MW1, Villalobo A2.Author information 1Department of Biology, University of Copenhagen, Copenhagen Biocenter 4-2-09 Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark. Electronic address: mabe@my.molbio.ku.dk.2Instituto de Investigaciones Biomédicas, Department of Cancer Biology, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/Arturo Duperier 4, E-28029 Madrid, Spain. Electronic address: antonio.villalobo@iib.uam.es.AbstractCalmodulin (CaM) is a ubiquitous Ca(2+) receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-dependent signaling systems in the control of vertebrate cell proliferation, programmed cell death and autophagy. The significance of CaM and interconnected CaM-regulated systems for the physiology of cancer cells including tumor stem cells, and processes required for tumor progression such as growth, tumor-associated angiogenesis and metastasis are highlighted. Furthermore, the potential targeting of CaM-dependent signaling processes for therapeutic use is discussed.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Feb;1843(2):398-435. doi: 10.1016/j.bbamcr.2013.10.021. Epub 2013 Nov 2.
- Calmodulin (CaM) is a ubiquitous Ca(2+) receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-depe
- PMID 24188867
Japanese Journal
- Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease
- Circulation journal : official journal of the Japanese Circulation Society 79(9), 2043-2049, 2015-09
- NAID 40020565894
- 微小環境を標的とした分子標的治療 (特集 固形がんの分子標的薬 : 基礎研究から創薬・開発・臨床まで) -- (がん分子標的治療の基礎)
- 日本臨床 73(8), 1283-1287, 2015-08
- NAID 40020541090
- Angiogenesis Inhibitor, Endostar, Prevents Vasa Vasorum Neovascularization in a Swine Atherosclerosis Model
- Journal of Atherosclerosis and Thrombosis 22(10), 1100-1112, 2015
- NAID 130005101331
Related Links
- Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen この本 ...
- Theranostics 2012; 2(8):801-814. doi:10.7150/thno.4419 Review Therapeutic Angiogenesis for Treating Cardiovascular Diseases Lorenzo Deveza 1, 2, Jeffrey Choi 3, Fan Yang 2,4, 1. School of Medicine, Stanford University ...
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★リンクテーブル★
| リンク元 | 「血管新生療法」「治療的血管新生」「血管新生促進療法」「治療的血管新生療法」「angiogenic therapy」 |
| 関連記事 | 「therapeutic」「therapeutics」 |
「血管新生療法」
「治療的血管新生」
「血管新生促進療法」
「治療的血管新生療法」
「angiogenic therapy」
「therapeutic」
- adj.
- 治療上の、治療学的な、治療的な、治療の、療法の、治療学の
- 関
- care、curative、curatively、cure、curing、practice、regimen、remedial、remediation、remedy、therapeutical、therapeutically、therapeutics、therapy、treat、treatment
「therapeutics」
- n.