- 関
- angiogenic therapy
WordNet
- relating to or involved in therapy; "therapeutic approach to criminality" (同)therapeutical
- branch of medicine concerned with the treatment of disease
- the formation of new blood vessels
PrepTutorEJDIC
- 治療[上]の
- 治療学
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 21:23:34」(JST)
[Wiki en表示]
Therapeutic angiogenesis is an experimental area of treatment of ischemia, the condition which associated with decrease in blood supply to certain body organs, tissue or part This usually caused by constriction or obstruction of the blood vessels. Angiogenesis is the natural healing process by which new blood vessels are formed to supply the organ or part in deficit with oxygen-rich blood. The goal of therapeutic angiogenesis is to stimulate the creation of new blood vessels in ischemic organs, tissues or parts in hope to increase the level of oxygen-rich blood reaching these areas.
See also
- Vascular endothelial growth factor
References
1. Isner JM. Therapeutic angiogenesis: a new frontier for vascular therapy. Vasc Med. 1996 1: 79-87.
2. Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature. 2005 Dec 15;438(7070): 967-74.
3. Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. Circulation. 2004 109: 2487-2491
4. Cao L, Mooney DJ. Spatiotemporal control over growth factor signaling for therapeutic neovascularization. Adv Drug Deliv Rev. 2007 Nov 10;59(13):1340-50.
External links
- Therapeutic Angiogenesis for Tissue Repair and Regeneration - from The Angiogenesis Foundation, 23 June 2009
UpToDate Contents
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English Journal
- Unraveling galectin-1 as a novel therapeutic target for cancer.
- Astorgues-Xerri L, Riveiro ME, Tijeras-Raballand A, Serova M, Neuzillet C, Albert S, Raymond E, Faivre S.Author information Oncology Therapeutic Development, 100 rue Martre, 92110 Clichy, France. Electronic address: lucile.astxer@wanadoo.fr.AbstractGalectins belong to a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues and displays a wide range of biological activities. In oncology, galectin-1 plays a pivotal role in tumor growth and in the multistep process of invasion, angiogenesis, and metastasis. Evidence indicates that galectin-1 exerts a variety of functions at different steps of tumor progression. Moreover, it has been demonstrated that galectin-1 cellular localization and galectin-1 binding partners depend on tumor localization and stage. Recently, galectin-1 overexpression has been extensively documented in several tumor types and/or in the stroma of cancer cells. Its expression is thought to reflect tumor aggressiveness in several tumor types. Galectin-1 has been identified as a promising drug target using synthetic and natural inhibitors. Preclinical data suggest that galectin-1 inhibition may lead to direct antiproliferative effects in cancer cells as well as antiangiogenic effects in tumors. We provide an up-to-date overview of available data on the role of galectin-1 in different molecular and biochemical pathways involved in human malignancies. One of the major challenges faced in targeting galectin-1 is the translation of current knowledge into the design and development of effective galectin-1 inhibitors in cancer therapy.
- Cancer treatment reviews.Cancer Treat Rev.2014 Mar;40(2):307-19. doi: 10.1016/j.ctrv.2013.07.007. Epub 2013 Aug 1.
- Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues and displays a wide range of biological activities. In oncology, galectin-1 plays a pivotal role in tumor growth and in
- PMID 23953240
- Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma.
- Bell D, Hanna EY, Miele L, Roberts D, Weber RS, El-Naggar AK.Author information Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: diana.bell@mdanderson.org.AbstractNotch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients.
- Annals of diagnostic pathology.Ann Diagn Pathol.2014 Feb;18(1):10-3. doi: 10.1016/j.anndiagpath.2013.10.001. Epub 2013 Oct 10.
- Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC
- PMID 24238845
- The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer.
- Berchtold MW1, Villalobo A2.Author information 1Department of Biology, University of Copenhagen, Copenhagen Biocenter 4-2-09 Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark. Electronic address: mabe@my.molbio.ku.dk.2Instituto de Investigaciones Biomédicas, Department of Cancer Biology, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/Arturo Duperier 4, E-28029 Madrid, Spain. Electronic address: antonio.villalobo@iib.uam.es.AbstractCalmodulin (CaM) is a ubiquitous Ca(2+) receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-dependent signaling systems in the control of vertebrate cell proliferation, programmed cell death and autophagy. The significance of CaM and interconnected CaM-regulated systems for the physiology of cancer cells including tumor stem cells, and processes required for tumor progression such as growth, tumor-associated angiogenesis and metastasis are highlighted. Furthermore, the potential targeting of CaM-dependent signaling processes for therapeutic use is discussed.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Feb;1843(2):398-435. doi: 10.1016/j.bbamcr.2013.10.021. Epub 2013 Nov 2.
- Calmodulin (CaM) is a ubiquitous Ca(2+) receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-depe
- PMID 24188867
Japanese Journal
- Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease
- Circulation journal : official journal of the Japanese Circulation Society 79(9), 2043-2049, 2015-09
- NAID 40020565894
- 微小環境を標的とした分子標的治療 (特集 固形がんの分子標的薬 : 基礎研究から創薬・開発・臨床まで) -- (がん分子標的治療の基礎)
- Angiogenesis Inhibitor, Endostar, Prevents Vasa Vasorum Neovascularization in a Swine Atherosclerosis Model
Related Links
- Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen この本 ...
- Theranostics 2012; 2(8):801-814. doi:10.7150/thno.4419 Review Therapeutic Angiogenesis for Treating Cardiovascular Diseases Lorenzo Deveza 1, 2, Jeffrey Choi 3, Fan Yang 2,4, 1. School of Medicine, Stanford University ...
★リンクテーブル★
[★]
- 英
- therapeutic angiogenesis、angiogenic therapy
- 関
- 血管新生促進療法、治療的血管新生、治療的血管新生療法
[★]
- 英
- therapeutic angiogenesis
- 関
- 血管新生促進療法、血管新生療法、治療的血管新生療法
[★]
- 英
- therapeutic angiogenesis
- 関
- 血管新生療法、治療的血管新生、治療的血管新生療法
[★]
- 英
- therapeutic angiogenesis
- 関
- 血管新生促進療法、血管新生療法、治療的血管新生
[★]
- 関
- therapeutic angiogenesis
[★]
- 治療上の、治療学的な、治療的な、治療の、療法の、治療学の
- 関
- care、curative、curatively、cure、curing、practice、regimen、remedial、remediation、remedy、therapeutical、therapeutically、therapeutics、therapy、treat、treatment
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- 関
- pharmacotherapeutic、pharmacotherapeutics、therapeutic、treatment