顆粒層
WordNet
- the removal of covering (同)stripping, uncovering, baring, husking
- one of several parallel layers of material arranged one on top of another (such as a layer of tissue or cells in an organism or a layer of sedimentary rock)
PrepTutorEJDIC
- 地層,岩層 / (社会的な)階層
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/01/02 23:44:42」(JST)
[Wiki en表示]
Histologic image showing a section of epidermis. Stratum granulosum labeled near center.
The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis.[1] Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with histidine- and cysteine-rich proteins that appear to bind the keratin filaments together. Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.[2][3]
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space. This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties. Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.[3]
Additional images
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Epidermis and dermis of human skin
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See also
- List of keratins expressed in the human integumentary system
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 2. ISBN 0-7216-2921-0.
- ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 7. ISBN 1-4160-3185-5.
- ^ a b Ovaere P; Lippens S; Vandenabeele P; Declercq W. (2009). "The emerging roles of serine protease cascades in the epidermis". Trends in Biochemical Sciences. 34 (9): 453–463. doi:10.1016/j.tibs.2009.08.001. PMID 19726197.
Skin and related structures
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Skin |
Epidermis |
- Stratum corneum
- Stratum lucidum
- Stratum granulosum
- Stratum spinosum
- Stratum basale
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Basement membrane |
- Basal keratinocyte
- Lamina lucida
- Lamina densa
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Dermis |
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Subcutaneous tissue |
- Panniculus/Pannus (Panniculus adiposus
- Panniculus carnosus)
- Membranous layer
- Loose connective tissue
- Superficial fascia
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Adnexa |
Skin glands |
- Sweat glands: Apocrine sweat gland
- Eccrine sweat gland
- Sebaceous
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Hair |
Root sheath |
- Outer root sheath
- Inner root sheath
- Henle's layer
- Huxley's layer
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Hair shaft |
- Cuticle
- Cortex
- Medulla
- Bulb with matrix cells
- Hair follicle
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Muscle |
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Pilosebaceous unit |
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Nail |
- Nail matrix
- Nail plate
- Eponychium
- Paronychium
- Hyponychium
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UpToDate Contents
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English Journal
- Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.
- Schaper K, Dickhaut J, Japtok L, Kietzmann M, Mischke R, Kleuser B, Bäumer W.SourceDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
- Journal of dermatological science.J Dermatol Sci.2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006. Epub 2013 Apr 6.
- BACKGROUND: It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes. Furthermore S1P has been demonstrated to inhibit cell growth in human keratinocytes. However, only little is known about the effect of S1P in hype
- PMID 23643308
- Papillomavirus-associated Cutaneous Papillomas in a Population of Wild Spotted Hyenas (Crocuta crocuta).
- Nelson KG, Engh AL, McKnight CA, Kiupel M, Wise AG, Maes RK, Stevens H, Heylen E, De Keyser K, Rector A, Van Ranst M, Flies AS, Holekamp KE.SourcePathology Department, MPI Research, Mattawan, Michigan 49071, USA.
- Journal of wildlife diseases.J Wildl Dis.2013 Jul;49(3):627-31. doi: 10.7589/2011-09-262.
- Beginning in 1997 Michigan State University Mara Hyena Project investigators observed waxing and waning progression of oral and genital masses during long-term behavioral observations of a population of wild spotted hyenas (Crocuta crocuta) from the Masai Mara Game Reserve, Kenya. From 1999-2000, we
- PMID 23778611
- Recombinant Filaggrin Is Internalized And Processed to Correct Filaggrin Deficiency.
- Stout TE, McFarland T, Mitchell JC, Appukuttan B, Timothy Stout J.SourceCasey Eye Institute, Oregon Health & Sciences University, Portland, OR, USA.
- The Journal of investigative dermatology.J Invest Dermatol.2013 Jun 21. doi: 10.1038/jid.2013.284. [Epub ahead of print]
- This study was designed to engineer a functional filaggrin monomer linked to a cell penetrating peptide (RMR) and test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (
- PMID 23792461
Japanese Journal
- Morphological and Functional Analyses of the Tight Junction in the Palatal Epithelium of Mouse
- Morphological and Functional Analyses of the Tight Junction in the Palatal Epithelium of Mouse
Related Links
- The stratum granulosum, sometimes known as the granular layer, is one of the layers in the epidermis, or outer part of the skin. There are five layers in the epidermis altogether, and the stratum granulosum is the one in ...
- stratum [stra´tum, strat´um] (L.) a sheetlike mass of tissue; see also lamina and layer. stratum basa´le the deepest layer of the epidermis, composed of a single layer of basophilic cells. Called also basal layer of epidermis. stratum ...
Related Pictures
★リンクテーブル★
[★]
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- A 5-year-old boy exhibits global denudation of the skin resulting from splitting of the epidermis at the stratum granulosum.
- 関
- (vt. adj.)denude,(n.)denudant , (adj.)denudational
[★]
- 英
- granular layer
- ラ
- stratum granulosum
- 関
- 皮膚
皮膚
卵胞
- 英
- granular layer
- ラ
- stratum granulosum
- 同
- 顆粒膜
[★]
顆粒層
- 関
- granular layer、stratum granulosum
[★]
- 関
- laminar, layer, strata, tier
[★]
顆粒膜
- 関
- granulosa