sterol esterase

ステロールエステラーゼ

関

cholesterol esterase

WordNet

1. any of a group of natural steroid alcohols derived from plants or animals; they are waxy insoluble substances (同)steroid alcohol

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/31 12:59:00」(JST)

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sterol esterase
Identifiers
EC number	3.1.1.13
CAS number	9026-00-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI Protein search

In enzymology, a sterol esterase (EC 3.1.1.13) is an enzyme that catalyzes the chemical reaction

steryl ester + H₂O sterol + fatty acid

Thus, the two substrates of this enzyme are steryl ester and H₂O, whereas its two products are sterol and fatty acid.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is steryl-ester acylhydrolase. Other names in common use include cholesterol esterase, cholesteryl ester synthase, triterpenol esterase, cholesteryl esterase, cholesteryl ester hydrolase, sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile acid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1AQL and 2BCE.

References

• Hyun J, Kothari H, Herm E, Mortenson J, Treadwell CR, Vahouny GV (1969). "Purification and properties of pancreatic juice cholesterol esterase". J. Biol. Chem. 244 (7): 1937–45. PMID 5780846.
• Okawa Y, Yamaguchi T (Tokyo). "Studies on sterol-ester hydrolase from Fusarium oxysporum. I Partial purification and properties". J. Biochem. (5): 1209–15. PMID 19426.
• Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal.. Methods of Biochemical Analysis 16: 219–72. doi:10.1002/9780470110348.ch4. ISBN 978-0-470-11034-8. PMID 4877146.
• Warnaar F (1987). "Triterpene ester synthesis in latex of Euphorbia species". Phytochemistry 26 (10): 2715–2721. doi:10.1016/S0031-9422(00)83578-5.

UpToDate Contents

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English Journal

• Potential of Ophiostoma piceae sterol esterase for biotechnologically relevant hydrolysis reactions.

• Cedillo VB, Prieto A, Martínez MJ.SourceCentro de Investigaciones Biológicas (CIB); Spanish National Research Council (CSIC); Madrid, Spain.
• Bioengineered.Bioengineered.2012 Nov 8;4(4). [Epub ahead of print]
• The ascomycete Ophiostoma piceae produces a sterol esterase (OPE) with high affinity toward p-nitrophenol, glycerol, and sterol esters. Recently, this enzyme has been heterologously expressed in the methylotrophic yeast Pichia pastoris under the AOX1 methanol-inducible promoter (PAOX1) using sorbito
• PMID 23138020

• Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice.

• Obrowsky S, Chandak PG, Patankar JV, Pfeifer T, Povoden S, Schreiber R, Haemmerle G, Levak-Frank S, Kratky D.SourceInstitute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria.
• Biochimica et biophysica acta.Biochim Biophys Acta.2012 Nov;1821(11):1406-14. doi: 10.1016/j.bbalip.2012.07.013. Epub 2012 Jul 27.
• Hormone sensitive lipase (HSL) regulates the hydrolysis of acylglycerols and cholesteryl esters (CE) in various cells and organs, including enterocytes of the small intestine. The physiological role of this enzyme in enterocytes, however, stayed elusive. In the present study we generated mice lackin
• PMID 22842588

Japanese Journal

• Heterologous expression of a fungal sterol esterase/lipase in different hosts : Effect on solubility, glycosylation and production

• Journal of bioscience and bioengineering 120(6), 637-643, 2015-12
• NAID 40020686876

• Factors Affecting Intestinal Absorption of Cholesterol and Plant Sterols and Stanols

• Journal of Oleo Science 64(1), 9-18, 2015
• NAID 130004800093

• 2P-252 Trichoderma sp.のコレステロールエステラーゼを用いた植物ステロール脂肪酸エステル連続合成系の開発(脂質工学,一般講演)

• 日本生物工学会大会講演要旨集 66, 169, 2014-08-05
• NAID 110009906636

Related Links

• Cholesterol Esterase - Worthington Enzyme Manual

I.U.B.: 3.1.1.13 C.A.S.: 9026-00-0 Enzymatic Reaction(image will open in a new window) Cholesterol esterase catalyzes the hydrolysis of sterol esters into their component sterols and fatty acids. The enzyme is found primarily in the ...

• Recombinant sterol esterase from Ophiostoma piceae: an ...

Background The ascomycete Ophiostoma piceae produces a sterol esterase (OPE) with high affinity towards p-nitrophenol, glycerol and sterol esters. Its hydrolytic activity on natural mixtures of triglycerides and sterol ...

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★リンクテーブル★

リンク元	「ステロールエステラーゼ」
拡張検索	「cholesterol esterase」
関連記事	「esterase」

「ステロールエステラーゼ」

　　[★]

英

sterol esterase

関

コレステロールエステラーゼ

「cholesterol esterase」

　　[★] コレステロールエステラーゼ

「esterase」

　　[★] エステラーゼ、エステル加水分解酵素、エステル分解酵素