WordNet

a family of proteins found in blood and milk and muscle and in plant seed
an amber, watery fluid, rich in proteins, that separates out when blood coagulates (同)blood_serum

PrepTutorEJDIC

グロブリン(動植物組織内の純蛋白(たんぱく)質の総称)
リンパ液 / 血清
serial / series / sermon

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/23 15:29:12」(JST)

wiki en

[Wiki en表示]

Not to be confused with globin or globular protein.

The globulins are a family of globular proteins that have higher molecular weights and water solubility values than the albumins. Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumin, and fibrinogen are the major blood proteins. The normal concentration of globulins in the blood is about 2.6-4.6 g/dL.

The term "globulin" is sometimes used synonymously with "globular protein". However, albumins are also globular proteins, but are not globulins. All other serum globular proteins are globulins.

Types of globulins[edit]

All globulins fall into one of the following four categories:

Alpha 1 globulins
Alpha 2 globulins
Beta globulins
Gamma globulins (one group of gamma globulins are the immunoglobulins, which are also known as "antibodies")

Globulins can be distinguished from one another using serum protein electrophoresis.

Reference ranges for blood tests, comparing blood content of globulins (shown in purple at right) with other constituents.

Sizes[edit]

Globulins exist in various sizes. The lightest globulins are the alpha globulins, which typically have molecular weights of around 92 kDa, while the heaviest class of globulins are the gamma globulins, which typically weigh about 120 kDa. Being the heaviest, the gamma globulins are among the slowest to segregate in gel electrophoresis. Since they are immunologically active, they are also called "immunoglobulins".

Plant globulins[edit]

Non-human globulin proteins exist as well, such as cucurbitin from squashes and vicilin and legumin from legumes and peas, functioning as protein storage within seeds. These proteins can cause allergic reactions if they bind with human IgE antibodies.^[1]

Pseudoglobulins and euglobulins[edit]

Pseudoglobulins are a class of globulins that are more soluble in ammonium sulfate than euglobulins. Pseudoglobulins are also soluble in pure water, while euglobulins are not.^[2]

References[edit]

^ Sanchez-Monge, R.; Lopez-Torrejón, G.; Pascual, C. Y.; Varela, J.; Martin-Esteban, M.; Salcedo, G. (12 November 2004). "Vicilin and convicilin are potential major allergens from pea". Clinical & Experimental Allergy 34 (11): 1747–1753. doi:10.1111/j.1365-2222.2004.02085.x.
^ Harris, T; Eagle (1935). "THE IMMUNOLOGICAL SPECIFICITY OF THE EUGLOBULIN AND PSEUDOGLOBULIN FRACTIONS OF HORSE AND HUMAN SERUM". J Gen Physiol 19 (2): 383–396. doi:10.1085/jgp.19.2.383. PMC 2141424. PMID 19872935.

External links[edit]

Cornell
Globulins at the US National Library of Medicine Medical Subject Headings (MeSH)

This protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. モノクローナル蛋白の認識 recognition of monoclonal proteins
2. 免疫不全症の内科的マネージメント medical management of immunodeficiency
3. 周産期心筋症：治療および予後 peripartum cardiomyopathy treatment and prognosis
4. 思春期における多嚢胞性卵巣症候群の診断的評価 diagnostic evaluation of polycystic ovary syndrome in adolescents
5. 免疫グロブリンの使用における一般原則 general principles in the use of immune globulin

English Journal

Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults.

Tsai MS1, Lin CY2, Lin CC1, Chen MH3, Hsu SH4, Chien KL5, Sung FC6, Chen PC7, Su TC8.
International journal of hygiene and environmental health.Int J Hyg Environ Health.2015 Jul;218(5):437-43. doi: 10.1016/j.ijheh.2015.03.008. Epub 2015 Mar 26.
BACKGROUND: Few studies have explored the association between perfluoroalkyl substances (PFAS) and reproductive hormones in adolescents and young adults.OBJECTIVES: This study aimed to investigate the association of PFAS with reproductive hormones in adolescents and young adults.METHODS: We recruite
PMID 25921520

Proteome evolution of wheat (Triticum aestivum L.) aleurone layer at fifteen stages of grain development.

Nadaud I1, Tasleem-Tahir A2, Chateigner-Boutin AL3, Chambon C4, Viala D4, Branlard G5.
Journal of proteomics.J Proteomics.2015 Jun 18;123:29-41. doi: 10.1016/j.jprot.2015.03.008. Epub 2015 Apr 2.
The aleurone layer (AL) is the grain peripheral tissue; it is rich in micronutrients, vitamins, antioxidants, and essential amino acids. This highly nutritive part of the grain has been less studied partly because its isolation is so laborious. In the present study, the ALs of Triticum aestivum (var
PMID 25841591

Prediction of respiratory disease and diarrhea in veal calves based on immunoglobulin levels and the serostatus for respiratory pathogens measured at arrival.

Pardon B1, Alliët J2, Boone R3, Roelandt S4, Valgaeren B5, Deprez P6.
Preventive veterinary medicine.Prev Vet Med.2015 Jun 15;120(2):169-76. doi: 10.1016/j.prevetmed.2015.04.009. Epub 2015 Apr 25.
Failure of passive transfer is a common problem in calves destined for veal production. At present it is unknown whether the risk for respiratory disease (BRD) or neonatal calf diarrhea (NCD) in the veal herd is associated with total immunoglobulin (Ig) and/or on the serostatus for respiratory patho
PMID 25937168

Japanese Journal

Sex Differences in the Associations of Testosterone and Sex Hormone-Binding Globulin With Metabolic Syndrome in Middle-Aged and Elderly Koreans:– The Namwon Study –

Kweon Sun-Seog,Shin Min-Ho,Nam Hae-Sung,Jeong Seul-Ki,Park Kyeong-Soo,Choi Jin-Su,Lee Young-Hoon
Circulation Journal 77(3), 734-740, 2013
… Background: We investigated the sex-dependent associations of testosterone and sex hormone-binding globulin (SHBG) levels with metabolic syndrome (MetS). … Serum total testosterone (TT) and SHBG levels were determined using a chemiluminescent microparticle immunoassay, and free testosterone (FT) concentrations were calculated. …
NAID 130002491330

ソバに含まれるIgE結合タンパク質に関する研究

佐藤里絵
日本食品化学学会誌 19(3), 172-177, 2012-12-21
… Mutational analysis of recombinant Fag e 2 (rFag e 2) revealed that 7 out of 10 Cys mutants showed weaker IgE binding to patient's serum than wild-type rFag e 2 (rFag e 2 WT). … Some spots were newly identified as 13S globulin protein subunits or isoforms. …
NAID 110009561743

Rh(E)血液型不適合妊娠に double filtration plasmapheresis (DFPP) を施行した1例

森澤洋介,吉田克法,望月裕司 [他],米田龍生,藤本清秀,平尾佳彦,佐道俊幸,小林浩
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 45(4), 363-366, 2012-04-28
Rh(E)式血液型不適合妊娠に対して二重膜濾過血漿交換分離法double filtration plasmapheresis（DFPP）を施行した1例を経験した．症例は33歳，女性，Rh式血液型はccDee，夫はCCDeE．2度の子宮内胎児死亡の既往があり，今回妊娠9週にて抗E抗体512倍と高値であり，妊娠12週2日よりDFPP（計34回）施行した．経過中に高度の胎児貧血を認めたため，5度の臍帯血 …
NAID 10030813952