WordNet

a lack of coordination of movements
involving or derived from the senses; "sensory experience"; "sensory channels" (同)sensorial
inability to coordinate voluntary muscle movements; unsteady movements and staggering gait (同)ataxy, dyssynergia, motor_ataxia

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感覚の
(光・温度・放射能などの)感知器

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/21 04:27:33」(JST)

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Sensory ataxia is both a symptom and a sign in neurology. It is a form of ataxia (loss of coordination) caused not by cerebellar dysfunction but by loss of sensory input into the control of movement.

Sensory ataxia is distinguished from cerebellar ataxia by the presence of near-normal coordination when the movement in question is visually observed by the patient, but marked worsening of coordination when the eyes are shut.

Sensory ataxia also lacks the associated features of cerebellar ataxia such as pendular tendon reflexes, scanning dysarthria, nystagmus and broken pursuit eye movements.

Patients with sensory ataxia often demonstrate pseudoathetosis and Romberg's sign. They usually complain of loss of balance in the dark, typically when closing their eyes in the shower or removing clothing over the head.

Causes

Sensory ataxia can be a manifestation of sensory large fiber peripheral neuropathies and conditions causing dysfunction of the dorsal columns of the spinal cord due to a variety of disorders: infectious, auto-immune, metabolic, toxic, vascular and hereditary diseases.^[1]^[2]^[3]

References

^ Spinazzi M, Angelini C, Patrini C (May 2010). "Subacute sensory ataxia and optic neuropathy with thiamine deficiency". Nature Reviews Neurology 6 (5): 288–93. doi:10.1038/nrneurol.2010.16. PMID 20308997.
^ Sghirlanzoni A, Pareyson D, Lauria G (June 2005). "Sensory neuron diseases". Lancet Neurol 4 (6): 349–61. doi:10.1016/S1474-4422(05)70096-X. PMID 15907739.
^ Moeller JJ, Macaulay RJ, Valdmanis PN, Weston LE, Rouleau GA, Dupré N (September 2008). "Autosomal dominant sensory ataxia: a neuroaxonal dystrophy". Acta Neuropathol. 116 (3): 331–6. doi:10.1007/s00401-008-0362-6. PMID 18347805.

UpToDate Contents

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1. 感覚消失患者へのアプローチ approach to the patient with sensory loss
2. 成人における小脳性運動失調の概要 overview of cerebellar ataxia in adults
3. ビタミンB12および葉酸欠乏症の診断および治療 diagnosis and treatment of vitamin b12 and folate deficiency
4. 脊髄に影響を与える疾患 disorders affecting the spinal cord
5. 銅欠乏性脊髄神経障害 copper deficiency myeloneuropathy

English Journal

Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.

Ji J1, Hassler ML1, Shimobayashi E1, Paka N1, Streit R1, Kapfhammer JP2.
Neurobiology of disease.Neurobiol Dis.2014 Oct;70:1-11. doi: 10.1016/j.nbd.2014.06.002. Epub 2014 Jun 14.
Spinocerebellar ataxias (SCAs) are hereditary diseases leading to Purkinje cell degeneration and cerebellar dysfunction. Most forms of SCA are caused by expansion of CAG repeats similar to other polyglutamine disorders such as Huntington's disease. In contrast, in the autosomal dominant SCA-14 the d
PMID 24937631

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.

Jiang T1, Yu JT2, Zhu XC1, Zhang QQ3, Cao L1, Wang HF1, Tan MS4, Gao Q5, Qin H6, Zhang YD5, Tan L7.
Neuropharmacology.Neuropharmacology.2014 Oct;85:121-30. doi: 10.1016/j.neuropharm.2014.05.032. Epub 2014 May 29.
In a variety of neurodegenerative tauopathies including Alzheimer's disease, frontotemporal dementia and some types of Parkinson's disease, tau protein is abnormally hyperphosphorylated by several kinases and eventually aggregates to form neurofibrillary tangles, a neurotoxic pathological characteri
PMID 24880087

Prevention of DNA damage by l-carnitine induced by metabolites accumulated in maple syrup urine disease in human peripheral leukocytes in vitro.

Mescka CP1, Wayhs CA2, Guerreiro G3, Manfredini V4, Dutra-Filho CS5, Vargas CR6.
Gene.Gene.2014 Sep 15;548(2):294-8. doi: 10.1016/j.gene.2014.07.051. Epub 2014 Jul 18.
Maple syrup urine disease (MSUD) is an inherited aminoacidopathy caused by a deficiency in branched-chain α-keto acid dehydrogenase complex activity that leads to the accumulation of the branched-chain amino acids (BCAAs) leucine (Leu), isoleucine, and valine and their respective α-keto-acids, α-
PMID 25046137

Japanese Journal

幼児期のめまい・平衡障害

坂田英明,遠藤まゆみ,加我君孝
Equilibrium research 71(4), 253-263, 2012-08-01
… In clinical practice, many children are brought to the Department of Pediatrics (Neurology) or the Department of Orthopedics with delayed gait, muscle hypotonia, or frequent falling-down.In this symposium, we review the diagnosis and pathogenesis of vertigo/disequilibrium during early childhood, focusing on rare diseases such as benign paroxysmal torticollis.Childhood vertigo is classified into 2 types: vertigo that children complain of (sensory disturbance) and disequilibrium-related balance abnormalities (motor control disturbance). …
NAID 10031026794

Demyelinating Features in Sensory Nerve Conduction in Fisher Syndrome

Shiga Kensuke,Tsuji Yukiko,Fujii Chihiro,Noto Yu-ichi,Nakagawa Masanori
Internal Medicine 51(17), 2307-2312, 2012
… Objective A significant number of patients with Fisher syndrome (FS) exhibit sensory symptoms in addition to the classical triad of opthalmoplegia, ataxia and areflexia. … Previous studies have shown the amplitudes of sensory nerve action potentials (SNAPs) to decrease in patients with FS, thus implying the presence of an axonal pathology in the sensory nerves. …
NAID 130002062355