WordNet

malignant tumor of the testis; usually occurring in older men (同)testicular_cancer

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 第I期セミノーマ（精上皮腫）の治療 treatment of stage i seminoma
2. ステージIIのセミノーマの治療 treatment of stage ii seminoma
3. 精巣胚細胞腫瘍の治療の概要 overview of the treatment of testicular germ cell tumors
4. 精巣胚細胞腫瘍における血清腫瘍マーカー serum tumor markers in testicular germ cell tumors
5. 進行した精巣胚細胞腫瘍のリスク別の初期治療 initial risk stratified treatment for advanced testicular germ cell tumors

English Journal

Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.

Kao CS1, Ulbright TM, Young RH, Idrees MT.Author information 1*Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN †The James Homer Wright Pathology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA.AbstractA total of 180 consecutive testicular cancers containing a component of embryonal carcinoma (EC) were reviewed to assess the morphologic features of the EC component. EC mostly (84%) occurred as a component of a mixed germ cell tumor, but 16% were pure. Solid (55%), glandular (17%), and papillary (11%) were the most common primary patterns (predominant architectural pattern occupying at least 50%), whereas other less common primary patterns included nested (3%), micropapillary (2%), anastomosing glandular (1%), sieve-like glandular (<1%), pseudopapillary (<1%), and blastocyst-like (<1%). Occasionally, EC developed predominantly in the context of polyembryoma-like (6%) and diffuse embryoma-like ("necklace" pattern) (3%) proliferations. In all, 69% had secondary architectural patterns, the most frequent being glandular (31%), papillary (14%), and solid (12%). An appliqué appearance, in which smudged and degenerate-appearing EC cells appear "applied" to the tumor periphery, was common (67%). EC cells with clear cytoplasm and distinct cell membranes (seminoma-like) were present in 11%, and dense lymphocytic infiltration and granulomatous inflammation were seen in 7% and 3%, respectively. Features simulating yolk sac tumor and teratoma were also seen: pseudoendodermal sinuses (34%), columnar cells (20%), and secretory-type subnuclear cytoplasmic vacuoles (6%). Syncytiotrophoblast cells were frequent (46%). Intratubular EC, typically partly necrotic and calcified, occurred in 24%. The associated stroma was more often non-neoplastic (53%) than neoplastic (29%). The rarity of some poorly characterized patterns of EC (micropapillary, blastocyst-like, anastomosing glandular, and sieve-like glandular) and some that overlap with those of other germ cell tumors, as well as some uncommon cytologic features, may result in misinterpretation, potentially impacting management. The association with other more common patterns and typical cytologic features, together with simple awareness of these variant morphologies, are helpful in establishing an accurate diagnosis of EC.
The American journal of surgical pathology.Am J Surg Pathol.2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171.
A total of 180 consecutive testicular cancers containing a component of embryonal carcinoma (EC) were reviewed to assess the morphologic features of the EC component. EC mostly (84%) occurred as a component of a mixed germ cell tumor, but 16% were pure. Solid (55%), glandular (17%), and papillary (1
PMID 24503753

Update on testicular germ cell tumors.

Nallu A1, Chimakurthi R, Hussain A, Mannuel HD.Author information 1aDepartment of Medicine, University of Maryland School of Medicine bBaltimore Veterans Affairs Medical Center cDepartment of Medicine, Pathology and Biochemistry, University of Maryland School of Medicine, Baltimore, Maryland, USA.AbstractPURPOSE OF REVIEW: This overview discusses several important developments in testicular germ cell tumors (TGCTs) over the past year.
Current opinion in oncology.Curr Opin Oncol.2014 May;26(3):294-8. doi: 10.1097/CCO.0000000000000068.
PURPOSE OF REVIEW: This overview discusses several important developments in testicular germ cell tumors (TGCTs) over the past year.RECENT FINDINGS: Genomic studies continue to investigate gene expression as possible markers for disease relapse and metastatic potential. Optimal treatment strategies
PMID 24675234

[Testicular seminomas : The classical and the less classical ones.]

Bode PK1, Moch H.Author information 1Institut für Klinische Pathologie, Universitätsspital Zürich, Schmelzbergstr. 12, 8091, Zürich, Schweiz, PeterKarl.Bode@usz.ch.AbstractTesticular germ cell tumors are generally rare but represent the most common solid neoplasms in young men. They are subdivided into seminomas and non-seminomatous germ cell tumors. Usually the diagnosis of a seminoma is straightforward due to the characteristic morphology, although problems in differential diagnosis can occur because of unusual histological growth patterns. This article describes the challenging differential diagnosis with respect to seminomas versus non-seminomatous germ cell tumors, sex cord stromal tumors, lymphomas and non-neoplastic conditions, such as scars and inflammatory changes. In addition, prognostic factors for seminomas are presented and discussed.
Der Pathologe.Pathologe.2014 Apr 19. [Epub ahead of print]
Testicular germ cell tumors are generally rare but represent the most common solid neoplasms in young men. They are subdivided into seminomas and non-seminomatous germ cell tumors. Usually the diagnosis of a seminoma is straightforward due to the characteristic morphology, although problems in diffe
PMID 24744185

Related Pictures

Anaplásico: 10% de los seminomas. seminomas Spermatocytic seminomas Cerca del30% de los seminomas aparece en Webpathology.com: A Collection of Surgical tumors than in seminomas | Cancer Immunity Testicular seminoma | Image | Radiopaedia seminoma - Humpath.com - Human pathology