WordNet

resulting from or employing derivation; "a derivative process"; "a highly derivative prose style"
a compound obtained from, or regarded as derived from, another compound
(linguistics) a word that is derived from another word; "`electricity is a derivative of `electric"
an alkaloid with anticholinergic effects that is used as a sedative and to treat nausea and to dilate the pupils in ophthalmic procedures; "transdermal scopolamine is used to treat motion sickness"; "someone sedated with scopolamine has difficulty lying" (同)hyoscine

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Design, Synthesis, and Biological Evaluation of Scutellarein Carbamate Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer's Disease.

Sang ZP1, Qiang XM1, Li Y1, Wu B1, Zhang H1, Zhao MG2, Deng Y1.
Chemical biology & drug design.Chem Biol Drug Des.2015 Nov;86(5):1168-77. doi: 10.1111/cbdd.12580. Epub 2015 May 20.
A series of scutellarein carbamate derivatives were designed and synthesized based on the multitarget-directed drug design strategy for treatment of Alzheimer's disease. Their acetylcholinesterase and butyrylcholinesterase inhibitory activities, antioxidant activities, metals chelation, and neuropro
PMID 25941042

6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.

Semenov VE1, Zueva IV2,3, Mukhamedyarov MA4, Lushchekina SV2,5, Kharlamova AD2, Petukhova EO4, Mikhailov AS2, Podyachev SN2, Saifina LF2, Petrov KA2,3,6, Minnekhanova OA2, Zobov VV2,3, Nikolsky EE2,3,4,6, Masson P3, Reznik VS2.
ChemMedChem.ChemMedChem.2015 Nov;10(11):1863-74. doi: 10.1002/cmdc.201500334. Epub 2015 Sep 28.
Novel 6-methyluracil derivatives with ω-(substituted benzylethylamino)alkyl chains at the nitrogen atoms of the pyrimidine ring were designed and synthesized. The numbers of methylene groups in the alkyl chains were varied along with the electron-withdrawing substituents on the benzyl rings. The co
PMID 26412714

Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.

Wechsler ME1, Yawn BP2, Fuhlbrigge AL3, Pace WD4, Pencina MJ5, Doros G6, Kazani S7, Raby BA3, Lanzillotti J8, Madison S2, Israel E3; BELT Investigators.
JAMA.JAMA.2015 Oct 27;314(16):1720-30. doi: 10.1001/jama.2015.13277.
IMPORTANCE: The efficacy and safety of long-acting β-agonists (LABAs) have been questioned. Black populations may be disproportionately affected by LABA risks.OBJECTIVE: To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with
PMID 26505596

The newly synthesized linoleic acid derivative DCP-LA ameliorates memory deficits in animal models treated with amyloid-β peptide and scopolamine

NAGATA Tetsu,YAMAMOTO Satoshi,YAGUCHI Takahiro,ISO Hiroyuki,TANAKA Akito,NISHIZAKI Tomoyuki
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 5(4), 122-126, 2005-12-01
NAID 10020420979

Ameliorative Effects of Azaindolizinone Derivative ZSET845 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Maze Learning in the Rat

Yamaguchi Yoshimasa,Higashi Masaya,Matsuno Toshiyuki [他],KAWASHIMA Seiichiro
The Japanese journal of pharmacology 87(3), 240-244, 2001-11-01
… Effects of ZSET845 (3,3-dibenzylimidazo[1,2-<i>a</i>]pyridin-2-(3<i>H</i>)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. …
NAID 10007368553

Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship

Abdel-Hafez Atef A.,Meselhy Meselhy R.,Nakamura Norio [他],HATTORI Masao,WATANABE Hiroshi,MUKARAMI Yukihisa,EL-GENDY Mahmoud A.,MAHFOUZ Nadia M.,MOHAMED Tarek A.
Biological & pharmaceutical bulletin 21(11), 1174-1179, 1998-11-15
… Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. … In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002,0.01,0.02 and 0.2 mmol/kg, and 30 min later (15 min before the experiment), scopolamine (1 mg/kg, i.p.) was given. …
NAID 110003639259