WordNet
- benign angioma consisting of a mass of blood vessels; some appear as birthmarks (同)haemangioma
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/19 22:37:58」(JST)
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| Dermatofibroma |
| Classification and external resources |
| ICD-10 |
D23 (ILDS D23.L62) |
| ICD-9 |
216.9 |
| ICD-O: |
M8830/0 |
| DiseasesDB |
29384 |
| eMedicine |
derm/96 |
| Patient UK |
Benign fibrous histiocytoma |
| MeSH |
D018219 |
Benign fibrous histiocytomas (also known as Dermal dendrocytoma,[1] Dermatofibroma,[2] Fibrous dermatofibroma,[2] Fibrous histiocytoma,[2]:668 Fibroma simplex,[1] Nodular subepidermal fibrosis,[1] and Sclerosing hemangioma[1]) are benign skin growths.[3]
Contents
- 1 Presentation
- 2 Immunohistochemical staining
- 3 See also
- 4 References
Presentation
Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan. In addition, they are often elevated or pedunculated. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. Dermatofibromas are classed as benign skin lesions meaning that they are completely harmless though it may be confused with a variety of subcutaneous tumours.[5]
Dermatofibroma can be found anywhere on the body but most often they are found on the legs and arms.[6]
Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[7]
Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4] The age group in which the nodule occurs is twenty to forty-five years.
It is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma.
Immunohistochemical staining
| Neoplasm |
CD34[1] |
Stromelysin-3[8] |
Factor XIIIa[9] |
| Dermatofibroma |
- |
+ |
+ |
| Dermatofibrosarcoma protuberans |
+ |
- |
- |
See also
- Dermatology
- Seborrheic keratosis
- Acrochordon, also called skin tags
- List of cutaneous conditions
References
- ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ a b c Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
- ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
- ^ a b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. Retrieved 2009-06-13.
- ^ Kyu Dong Jung et.al, Subcutaneous Dermatofibroma, Ann Dermatol. 2011 May; 23(2): 254–257. Published online 2011 May 27. doi: 10.5021/ad.2011.23.2.254
- ^ "dermatofibroma" at Dorland's Medical Dictionary
- ^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036.
- ^ Kim HJ, Lee JY, Kim SH, et al. (August 2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171.
- ^ http://emedicine.medscape.com/article/1056742-overview
|
Connective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)
|
|
| Not otherwise specified |
- Soft-tissue sarcoma
- Desmoplastic small-round-cell tumor
|
|
| Connective tissue neoplasm |
| Fibromatous |
| Fibroma/fibrosarcoma: |
- Dermatofibrosarcoma protuberans
- Desmoplastic fibroma
|
|
| Fibroma/fibromatosis: |
- Aggressive infantile fibromatosis
- Aponeurotic fibroma
- Collagenous fibroma
- Diffuse infantile fibromatosis
- Familial myxovascular fibromas
- Fibroma of tendon sheath
- Fibromatosis colli
- Infantile digital fibromatosis
- Juvenile hyaline fibromatosis
- Plantar fibromatosis
- Pleomorphic fibroma
- Oral submucous fibrosis
|
|
| Histiocytoma/histiocytic sarcoma: |
- Benign fibrous histiocytoma
- Malignant fibrous histiocytoma
- Atypical fibroxanthoma
- Solitary fibrous tumor
|
|
|
| Myxomatous |
- Myxoma/myxosarcoma
- Cutaneous myxoma
- Superficial acral fibromyxoma
- Angiomyxoma
- Ossifying fibromyxoid tumour
|
|
| Fibroepithelial |
- Brenner tumour
- Fibroadenoma
- Phyllodes tumor
|
|
| Synovial-like |
- Synovial sarcoma
- Clear-cell sarcoma
|
|
|
| Lipomatous |
- Lipoma/liposarcoma
- Myelolipoma
- Myxoid liposarcoma
- PEComa
- Chondroid lipoma
- Intradermal spindle cell lipoma
- Pleomorphic lipoma
- Lipoblastomatosis
- Spindle cell lipoma
- Hibernoma
|
|
| Myomatous |
| general: |
|
|
| smooth muscle: |
|
|
| skeletal muscle: |
- Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma
- Alveolar rhabdomyosarcoma
|
|
- Leiomyoma
- Angioleiomyoma
- Angiolipoleiomyoma
- Genital leiomyoma
- Leiomyosarcoma
- Multiple cutaneous and uterine leiomyomatosis syndrome
- Multiple cutaneous leiomyoma
- Neural fibrolipoma
- Solitary cutaneous leiomyoma
- STUMP
|
|
|
| Complex mixed and stromal |
- Adenomyoma
- Pleomorphic adenoma
- Mixed Müllerian tumor
- Mesoblastic nephroma
- Wilms' tumor
- Malignant rhabdoid tumour
- Clear-cell sarcoma of the kidney
- Hepatoblastoma
- Pancreatoblastoma
- Carcinosarcoma
|
|
| Mesothelial |
- Mesothelioma
- Adenomatoid tumor
|
|
|
|
|
| Description |
- Anatomy
- head
- neck
- arms
- chest and back
- diaphragm
- abdomen
- genital area
- legs
- Muscle tissue
- Physiology
- Development
|
|
| Disease |
- Myopathy
- Soft tissue
- Connective tissue
- Congenital
- abdomen
- muscular dystrophy
- Neoplasms and cancer
- Injury
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- anti-inflammatory
- muscle relaxants
|
|
|
|
Tumors: Skin neoplasm, dermis (C44/D23, 173/216)
|
|
| Dermis |
- Benign fibrous histiocytoma/dermatofibrosarcoma protuberans
- Dermatofibrosarcoma protuberans
|
|
Subcutaneous
tumors |
Connective and
vascular |
- see Template:Soft tissue tumors and sarcomas, Template:Vascular tumors, Template:Myeloid malignancy (for mastocytosis)
|
|
| Other |
| urogenital: |
- Hirsuties coronae glandis
|
|
| neuro: |
- Solitary neurofibroma
- Cutaneous meningioma
- Ganglioneuroma
- Schwannoma
- Palisaded encapsulated neuroma
- Infantile neuroblastoma
- Neuroma cutis
|
|
| bone/cartilage: |
- Chordoma
- Extraskeletal chondroma
|
|
| nevus: |
- Nevus anemicus
- Nevus flammeus
- Nevus flammeus nuchae
- Nevus lipomatosus superficialis
- Nevus oligemicus
- Connective tissue nevus
- Midline nevus flammeus
- Porokeratotic eccrine ostial and dermal duct nevus
|
|
| histiocytoma: |
- Pleomorphic undifferentiated sarcoma
- Plexiform fibrohistiocytic tumor
- Progressive nodular histiocytoma
|
|
- Teratoma
- Adenoma sebaceum
- Metastatic carcinoma
- Giant-cell tumor of the tendon sheath
- Glomus tumor
- Granular cell tumor
- Carcinoid
- Desmoid tumor
- Neurothekeoma
- Angiokeratoma
- Zosteriform metastasis
- Keratinizing metaplasia
- Epithelioid sarcoma
|
|
|
|
|
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Congenital
- Tumors
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
|
|
|
UpToDate Contents
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English Journal
- Clustered pulmonary sclerosing pneumocytoma in a young man: a case report.
- Shin SY1, Kim MY2, Lee HJ3, Oh SY3, Jang SJ4.
- Clinical imaging.Clin Imaging.2014 Jul-Aug;38(4):532-5. doi: 10.1016/j.clinimag.2014.01.016. Epub 2014 Feb 7.
- Pulmonary sclerosing pneumocytoma is a rare, benign lung tumor that usually occurs in middle-aged women. It usually manifests as isolated pulmonary nodules and is often confused with other solitary, benign nodules. We present a case of sclerosing pneumocytoma with clustered lung nodules and surround
- PMID 24667045
- STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics.
- Cheah AL1, Billings SD, Goldblum JR, Carver P, Tanas MZ, Rubin BP.
- Pathology.Pathology.2014 Jun 20. [Epub ahead of print]
- SUMMARY: Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours
- PMID 24977739
Japanese Journal
- 喜多 秀文,白石 裕治,葛城 直哉 [他]
- 胸部外科 = The Japanese journal of thoracic surgery 66(13), 1141-1144, 2013-12
- NAID 40019880030
- 脾sclerosing angiomatoid nodular transformationの1例
- 水谷 文俊,河野 弘,米山 文彦,佐竹 立成,氏平 伸子
- 日本臨床外科学会雑誌 74(12), 3479-3485, 2013
- … された．造影CTで脾血管腫と診断し経過観察していたが，増大傾向を認めたため，悪性疾患の可能性も否定できず診断的治療目的で当科に紹介となった．腹腔鏡下脾摘術を施行し，免疫組織化学検査所見でsclerosing angiomatoid nodular transformationと診断した．本疾患は非常にまれな脾腫瘤形成性良性疾患と考えられ，本邦報告例は6例のみであった．本症例を加えた7例の臨床病理学的特徴を検討し文献的考察を加えて報告する …
- NAID 130004518615
Related Links
- 詳細の表示を試みましたが、サイトのオーナーによって制限されているため表示できません。
- Historic misnomer "sclerosing hemangioma" originated from morphologic similarity to a dermatopathology lesion that was previously called "sclerosing hemangioma", now known as dermatofibroma / fibrous histiocytoma Also called ...
Related Pictures
★リンクテーブル★
[★]
- 英
- sclerosing hemangioma、sclerosing angioma
- 関
- 線維性組織球腫、良性線維性組織球腫、皮膚線維腫。肺腫瘍、肺良性腫瘍
- 肺の良性腫瘍であって、中年女性に好発する。肺胞上皮由来の組織で真の血管腫ではない。辺縁平滑類円形。(YN. I-90)
- 下肺葉に好発。気管支動脈造影ではメロンの皮様網目血管走行。
[★]
硬化性血管腫
- 関
- benign fibrous histiocytoma、dermatofibroma、fibrous histiocytoma、sclerosing hemangioma
[★]
- 関
- cirrhotic、sclerogenous、sclerotic