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Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"^[1] "Dermatofibroma,"^[2] "Fibrous dermatofibroma,"^[2] "Fibrous histiocytoma"^[2]^:668, "Fibroma simplex",^[1] "Nodular subepidermal fibrosis",^[1] and "Sclerosing hemangioma"^[1]) are benign skin growths.^[3]

Presentation

Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan. In addition, they are often elevated or pedunculated. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.^[4] They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in a dermatofibroma.

They are usually found on the leg.^[5]

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.^[6]

Dermatofibromas occur most often in women; the male to female ratio is about 1:4.^[4] The age group in which the nodule occurs is twenty to forty-five years.

Immunohistochemical staining

Neoplasm	CD34^[1]	Stromelysin-3^[7]	Factor XIIIa^[8]
Dermatofibroma	+	+	+
Dermatofibrosarcoma protuberans	+	-	-

References

^ ^a ^b ^c ^d ^e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
^ ^a ^b ^c Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
^ ^a ^b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. http://emedicine.medscape.com/article/1056742-overview. Retrieved 2009-06-13.
^ "dermatofibroma" at Dorland's Medical Dictionary
^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=130&page=831.
^ Kim HJ, Lee JY, Kim SH, et al. (August 2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171.
^ http://emedicine.medscape.com/article/1056742-overview

UpToDate Contents

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1. 皮膚の良性病変の概要 overview of benign lesions of the skin
2. 隆起性皮膚線維肉腫：疫学、病因、臨床症状、診断、および病期分類 dermatofibrosarcoma protuberans epidemiology pathogenesis clinical presentation diagnosis and staging
3. スピッツ母斑様色素細胞性腫瘍：スピッツ母斑および異型スピッツ腫瘍：臨床的特徴、診断および管理 spitzoid melanocytic neoplasms spitz nevus and atypical spitz tumors
4. 外陰部病変の鑑別診断 differential diagnosis of vulvar lesions
5. 爪疾患の概要 overview of nail disorders

English Journal

Benign fibrous histiocytoma: Particular aspects on confocal laser scanning microscopy.

Pereira Guedes RV, Noronha de Menezes NM, Leite IB, Baptista MA.SourceDermatology Department Centro Hospitalar de Vila Nova de Gaia Rua Conceição Fernandes 4434-502 Vila Nova de Gaia, Portugal.
European journal of dermatology : EJD.Eur J Dermatol.2012 Mar 16. [Epub ahead of print]
PMID 22426332

Dermatofibromas treated with pulsed dye laser: clinical and dermoscopic outcomes.

Alonso Castro L, Boixeda de Miquel P, Segura Palacios JM, de Daniel Rodríguez C, Jiménez Gómez N, Ballester Martínez A.AbstractDermatofibroma(DF), a common benign skin tumour, sometimes requires treatment either because of cosmetic concern or for associated symptoms. However no effective treatment with optimal cosmetic outcomes has been reported. An effective and safe therapeutic option could be treatment with pulsed dye laser(PDL). Twenty-two DFs in 15 patients were treated with PDL at 595-nm wavelength, using a spot size of 7 mm, a pulse duration of 2 ms and a fluence of 11 J/cm(2) with 2 or 3 stacked pulses. Clinical and dermoscopic photographs were taken before and after therapy. Global clinical improvement was higher than 50% in 12 lesions. Patient satisfaction assessment showed 73% of patients as satisfied or very satisfied. All lesions showed changes from the previous dermoscopic pattern. We consider that PDL could be a safe, palliative treatment as it is well accepted by patients and has a better cosmetic outcome than surgical excision.
Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.J Cosmet Laser Ther.2012 Mar 2. [Epub ahead of print]
Dermatofibroma(DF), a common benign skin tumour, sometimes requires treatment either because of cosmetic concern or for associated symptoms. However no effective treatment with optimal cosmetic outcomes has been reported. An effective and safe therapeutic option could be treatment with pulsed dye la
PMID 22384809

Japanese Journal

症例報告全身性エリテマトーデス,Sjogren症候群に合併した多発性皮膚線維腫の1例

太田美和,笹尾ゆき,岩原邦夫
臨床皮膚科 65(4), 311-313, 2011-04
NAID 40018794147

富細胞性皮膚線維腫の1例

佐藤勇樹,小林彩,木藤健治,古賀弘志,林宏一,浅野功治,上原剛,高田実
Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(1), 21-24, 2010-05-15
47歳男性。7ヵ月前より右肩部に赤黒い結節が出現，3ヵ月から急速に増大し，出血を認めるようになった。初診時右肩に33×26×28mmの潰瘍化した半球状の紅色腫瘤を認めた。下床との可動性は良好であった。造影MRIでは内部構造が均一で境界明瞭な結節であり，筋や骨の浸潤は認められなかった。線維組織球系の肉腫を疑い，全身麻酔下に全摘切除を行った。病理組織学的に主に真皮に軽度の核異型を伴う紡錘形細胞が花むし …
NAID 10026549750